Guest guest Posted September 27, 2005 Report Share Posted September 27, 2005 : If there is a perforation (I assume you mean of the intestines), what symptoms would you have? I assume it would be a big deal with lots of pain but I really don't know what to watch for. Is your mom young? Sounds like she is doing well. Was the tumor inoperable? Is it shrinking with the Avastin? What are the problems with ovarian cancer patients that you refer to? Thanks so much. in California In a message dated 9/27/2005 2:00:52 PM Pacific Standard Time, sftfemme@... writes: Jane, My mother is on Avastin right now and we just had an appointment with the Dr to discuss if she should continue it. My mom had heard about the issues that patients with ovarian cancer are having with Avastin. She was very concerned. My mom has rectal cancer. They were unable to remove her tumor, its very advanced so it will eventually end her life. The Dr has told my mom that he plans to leave her on the Avastin indefinitely, as long as she will take it. What I can tell you about Avastin is that for my mom its working. Her CEA level went from 89.5 to 2.4 in 10 treatments (with oxal,leuk and 5fu). Her Dr. has not seen any perforations that he could account to Avastin but its a risk that is there. My mom has decided that she will continue to take the Avastin for now because it gives her the best chance to stay around. Has anyone else been on Avastin long term? I would be interested to hear what they have to say too. [Non-text portions of this message have been removed] Quote Link to comment Share on other sites More sharing options...
Guest guest Posted September 28, 2005 Report Share Posted September 28, 2005 My mom is 59 and she was inoperable. I would think that a tear or rupture in the intestines would be very painful. Her tumor has shrunk but not enough that it will be able to be removed. There's several articles about the trial with avastin for overian cancer patients. I believe 5 out of 44 patients were seeing ruptures or tears. They stopped the trial because of it. But I have to say that even with that, Avastin is the best out there especially when your stage IV Quote Link to comment Share on other sites More sharing options...
Guest guest Posted September 28, 2005 Report Share Posted September 28, 2005 i would also agree that avastin is the most effective treatment out there, if given with another chemo like xeloda or oxaliplatin. any intestinal perforation would cause great abdominal pain, bleeding, obstruction, nausea, vomiting. i think anytime there is nausea, vomiting, constipation/diarrhea that you should contact your onc immediately because these are signs of perforation or obstruction. sftfemme@... wrote: My mom is 59 and she was inoperable. I would think that a tear or rupture in the intestines would be very painful. Her tumor has shrunk but not enough that it will be able to be removed. There's several articles about the trial with avastin for overian cancer patients. I believe 5 out of 44 patients were seeing ruptures or tears. They stopped the trial because of it. But I have to say that even with that, Avastin is the best out there especially when your stage IV Quote Link to comment Share on other sites More sharing options...
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