Oxaliplatin & 5FU - info needed

[Guest guest]

Hi everyone:

Last week was chemo week for me. It is supposed to be a 5 hour

infusion at the oncologist's office beginning with pre-meds, then

Avastin, followed by Oxaliplatin/Leucovorin. After that, I am hooked

up to the 48 hour pump with 5FU which I wear at home for the next 2

days. Last Tuesday, they forgot to turn on my 48 hour pump when I

left the office so I wore it thinking it was working for about 28

hours. At that time, I saw something flashing in the upper right

side of the pump and called the pump manufacturer only to find it had

not been turned on. I turned it on then and had to stay with the

pump until 6 p.m. on Friday night.

My question is this: I understood that Oxaliplatin/Leucovorin needs

to work together with 5FU to fight this cancer. That is, if used

separately, Oxaliplatin doesn't work. If I went 28 hours between the

infusion of Oxaliplatin and the 5FU, what is the effect? Has this

happened to anyone? Has anyone done any research on this?

Thanks as always for your help.

in California

[Guest guest]

Ingrid:

I was getting the 5FU bolus shot and then the 48 hour pump. However, they

have reduced my chemo 2 times: first they reduced it by 20% after I was in

the emergency room; then they took out the 5FU bolus shot because I was still

too sick. That was done for the first time last week. I just finished chemo

round 4 of 12 and I am so sick from it I can't get out of bed for at least 5

days. Then I am still sick until around day 7 or 8. Is this unusual??

Just a thought. But when I did chemo they usually gave a shot of 5-fu

before they started the pump. Did you get the bolos shot before they

forgot to start the pump? Ingrid

> Hi everyone:

>

> Last week was chemo week for me. It is supposed to be a 5 hour

> infusion at the oncologist's office beginning with pre-meds, then

> Avastin, followed by Oxaliplatin/Leucovorin. After that, I am

hooked

> up to the 48 hour pump with 5FU which I wear at home for the next 2

> days. Last Tuesday, they forgot to turn on my 48 hour pump when I

> left the office so I wore it thinking it was working for about 28

> hours. At that time, I saw something flashing in the upper right

> side of the pump and called the pump manufacturer only to find it

had

> not been turned on. I turned it on then and had to stay with the

> pump until 6 p.m. on Friday night.

>

> My question is this: I understood that Oxaliplatin/Leucovorin

needs

> to work together with 5FU to fight this cancer. That is, if used

> separately, Oxaliplatin doesn't work. If I went 28 hours between

the

> infusion of Oxaliplatin and the 5FU, what is the effect? Has this

> happened to anyone? Has anyone done any research on this?

>

> Thanks as always for your help.

>

> in California

[Guest guest]

Ingrid:

I was getting the 5FU bolus shot and then the 48 hour pump. However, they

have reduced my chemo 2 times: first they reduced it by 20% after I was in

the emergency room; then they took out the 5FU bolus shot because I was still

too sick. That was done for the first time last week. I just finished chemo

round 4 of 12 and I am so sick from it I can't get out of bed for at least 5

days. Then I am still sick until around day 7 or 8. Is this unusual??

Just a thought. But when I did chemo they usually gave a shot of 5-fu

before they started the pump. Did you get the bolos shot before they

forgot to start the pump? Ingrid

> Hi everyone:

>

> Last week was chemo week for me. It is supposed to be a 5 hour

> infusion at the oncologist's office beginning with pre-meds, then

> Avastin, followed by Oxaliplatin/Leucovorin. After that, I am

hooked

> up to the 48 hour pump with 5FU which I wear at home for the next 2

> days. Last Tuesday, they forgot to turn on my 48 hour pump when I

> left the office so I wore it thinking it was working for about 28

> hours. At that time, I saw something flashing in the upper right

> side of the pump and called the pump manufacturer only to find it

had

> not been turned on. I turned it on then and had to stay with the

> pump until 6 p.m. on Friday night.

>

> My question is this: I understood that Oxaliplatin/Leucovorin

needs

> to work together with 5FU to fight this cancer. That is, if used

> separately, Oxaliplatin doesn't work. If I went 28 hours between

the

> infusion of Oxaliplatin and the 5FU, what is the effect? Has this

> happened to anyone? Has anyone done any research on this?

>

> Thanks as always for your help.

>

> in California

[Guest guest]

The biological half life of oxilaplatin in the body is much longer than the

biological half life of 5FU. Thus while you got a late start with the fanny

pack you still had time with both 5FU and oxilaplatin in the body at the same

time. I am sure you had an initial 5FU shot that got you off to a good start

so the the late start may not have had a real adverse effect on your

treatment. If not for the fanny pack the 5FU would be gone in less than a day

while

the oxilaplatin does not totally disappear for 3-4 days. That is why lowest

blood counts are around day 5. Good luck

[Guest guest]

The biological half life of oxilaplatin in the body is much longer than the

biological half life of 5FU. Thus while you got a late start with the fanny

pack you still had time with both 5FU and oxilaplatin in the body at the same

time. I am sure you had an initial 5FU shot that got you off to a good start

so the the late start may not have had a real adverse effect on your

treatment. If not for the fanny pack the 5FU would be gone in less than a day

while

the oxilaplatin does not totally disappear for 3-4 days. That is why lowest

blood counts are around day 5. Good luck

[Guest guest]

Thank you so much for this info. How did you learn about this? Also, I

don't recognize your address. Please put your name on your posts so I can

respond directy to you. One more question: since I did NOT receive the 5FU

bolus

last week (they were cutting down my chemo dose), will this make a

difference? In other words, I went from the Oxaliplatin infusion directly to

the pump

without the bolus.

Thanks again.

in California

In a message dated 9/28/2005 7:46:24 PM Pacific Standard Time,

asorr55555@... writes:

The biological half life of oxilaplatin in the body is much longer than the

biological half life of 5FU. Thus while you got a late start with the

fanny

pack you still had time with both 5FU and oxilaplatin in the body at the

same

time. I am sure you had an initial 5FU shot that got you off to a good

start

so the the late start may not have had a real adverse effect on your

treatment. If not for the fanny pack the 5FU would be gone in less than a

day while

the oxilaplatin does not totally disappear for 3-4 days. That is why lowest

blood counts are around day 5. Good luck

[Non-text portions of this message have been removed]

[Guest guest]

With the short biological half life of 5FU thye best way to get the best

combination of minimal side effects and cancer fighting is to reduce or

elininate or reduce the bolus infusion and maintain the constant fanny pack

infusion.. The approach is standard when the 5FU must be reduced.

[Guest guest]

With the short biological half life of 5FU thye best way to get the best

combination of minimal side effects and cancer fighting is to reduce or

elininate or reduce the bolus infusion and maintain the constant fanny pack

infusion.. The approach is standard when the 5FU must be reduced.

[Guest guest]

, I feel bad you had to go through this, but I am sure it was

an honest mistake. I am no doctor but before they started the other

chemo drugs they used to give 5-FU by itself. I would ask the doctor

about this to make sure. Hope it did its job of killing any any

cancer cells. Praying for YOU!! Ingrid

> Hi everyone:

>

> Last week was chemo week for me. It is supposed to be a 5 hour

> infusion at the oncologist's office beginning with pre-meds, then

> Avastin, followed by Oxaliplatin/Leucovorin. After that, I am

hooked

> up to the 48 hour pump with 5FU which I wear at home for the next 2

> days. Last Tuesday, they forgot to turn on my 48 hour pump when I

> left the office so I wore it thinking it was working for about 28

> hours. At that time, I saw something flashing in the upper right

> side of the pump and called the pump manufacturer only to find it

had

> not been turned on. I turned it on then and had to stay with the

> pump until 6 p.m. on Friday night.

>

> My question is this: I understood that Oxaliplatin/Leucovorin

needs

> to work together with 5FU to fight this cancer. That is, if used

> separately, Oxaliplatin doesn't work. If I went 28 hours between

the

> infusion of Oxaliplatin and the 5FU, what is the effect? Has this

> happened to anyone? Has anyone done any research on this?

>

> Thanks as always for your help.

>

> in California

[Guest guest]

, I feel bad you had to go through this, but I am sure it was

an honest mistake. I am no doctor but before they started the other

chemo drugs they used to give 5-FU by itself. I would ask the doctor

about this to make sure. Hope it did its job of killing any any

cancer cells. Praying for YOU!! Ingrid

> Hi everyone:

>

> Last week was chemo week for me. It is supposed to be a 5 hour

> infusion at the oncologist's office beginning with pre-meds, then

> Avastin, followed by Oxaliplatin/Leucovorin. After that, I am

hooked

> up to the 48 hour pump with 5FU which I wear at home for the next 2

> days. Last Tuesday, they forgot to turn on my 48 hour pump when I

> left the office so I wore it thinking it was working for about 28

> hours. At that time, I saw something flashing in the upper right

> side of the pump and called the pump manufacturer only to find it

had

> not been turned on. I turned it on then and had to stay with the

> pump until 6 p.m. on Friday night.

>

> My question is this: I understood that Oxaliplatin/Leucovorin

needs

> to work together with 5FU to fight this cancer. That is, if used

> separately, Oxaliplatin doesn't work. If I went 28 hours between

the

> infusion of Oxaliplatin and the 5FU, what is the effect? Has this

> happened to anyone? Has anyone done any research on this?

>

> Thanks as always for your help.

>

> in California

[Guest guest]

Just a thought. But when I did chemo they usually gave a shot of 5-fu

before they started the pump. Did you get the bolos shot before they

forgot to start the pump? Ingrid

> Hi everyone:

>

> Last week was chemo week for me. It is supposed to be a 5 hour

> infusion at the oncologist's office beginning with pre-meds, then

> Avastin, followed by Oxaliplatin/Leucovorin. After that, I am

hooked

> up to the 48 hour pump with 5FU which I wear at home for the next 2

> days. Last Tuesday, they forgot to turn on my 48 hour pump when I

> left the office so I wore it thinking it was working for about 28

> hours. At that time, I saw something flashing in the upper right

> side of the pump and called the pump manufacturer only to find it

had

> not been turned on. I turned it on then and had to stay with the

> pump until 6 p.m. on Friday night.

>

> My question is this: I understood that Oxaliplatin/Leucovorin

needs

> to work together with 5FU to fight this cancer. That is, if used

> separately, Oxaliplatin doesn't work. If I went 28 hours between

the

> infusion of Oxaliplatin and the 5FU, what is the effect? Has this

> happened to anyone? Has anyone done any research on this?

>

> Thanks as always for your help.

>

> in California

[Guest guest]

Just a thought. But when I did chemo they usually gave a shot of 5-fu

before they started the pump. Did you get the bolos shot before they

forgot to start the pump? Ingrid

> Hi everyone:

>

> Last week was chemo week for me. It is supposed to be a 5 hour

> infusion at the oncologist's office beginning with pre-meds, then

> Avastin, followed by Oxaliplatin/Leucovorin. After that, I am

hooked

> up to the 48 hour pump with 5FU which I wear at home for the next 2

> days. Last Tuesday, they forgot to turn on my 48 hour pump when I

> left the office so I wore it thinking it was working for about 28

> hours. At that time, I saw something flashing in the upper right

> side of the pump and called the pump manufacturer only to find it

had

> not been turned on. I turned it on then and had to stay with the

> pump until 6 p.m. on Friday night.

>

> My question is this: I understood that Oxaliplatin/Leucovorin

needs

> to work together with 5FU to fight this cancer. That is, if used

> separately, Oxaliplatin doesn't work. If I went 28 hours between

the

> infusion of Oxaliplatin and the 5FU, what is the effect? Has this

> happened to anyone? Has anyone done any research on this?

>

> Thanks as always for your help.

>

> in California

[Guest guest]

Hi , when you say your sick from it do you mean vomitting /nausea sick

, or just allllllllll over sick?

When Joe had his treatment ( same as yours ) he got treatments Monday and was

S.I.C.K. til Friday at least. This went on for 5 months with them trying an

assortment of anti nausea meds until FINALLY they gave him Emend, morning

before treatment he would take a adavant, compazine and Emend , that was before

he even left for the chemo place, there he got anti nausea meds / plus a booster

shot of one , then his chemo , he was still sick til friday but minimum

vomitting on that

Deb

brencolinmom@... wrote:

Ingrid:

I was getting the 5FU bolus shot and then the 48 hour pump. However, they

have reduced my chemo 2 times: first they reduced it by 20% after I was in

the emergency room; then they took out the 5FU bolus shot because I was still

too sick. That was done for the first time last week. I just finished chemo

round 4 of 12 and I am so sick from it I can't get out of bed for at least 5

days. Then I am still sick until around day 7 or 8. Is this unusual??

Just a thought. But when I did chemo they usually gave a shot of 5-fu

before they started the pump. Did you get the bolos shot before they

forgot to start the pump? Ingrid

> Hi everyone:

>

> Last week was chemo week for me. It is supposed to be a 5 hour

> infusion at the oncologist's office beginning with pre-meds, then

> Avastin, followed by Oxaliplatin/Leucovorin. After that, I am

hooked

> up to the 48 hour pump with 5FU which I wear at home for the next 2

> days. Last Tuesday, they forgot to turn on my 48 hour pump when I

> left the office so I wore it thinking it was working for about 28

> hours. At that time, I saw something flashing in the upper right

> side of the pump and called the pump manufacturer only to find it

had

> not been turned on. I turned it on then and had to stay with the

> pump until 6 p.m. on Friday night.

>

> My question is this: I understood that Oxaliplatin/Leucovorin

needs

> to work together with 5FU to fight this cancer. That is, if used

> separately, Oxaliplatin doesn't work. If I went 28 hours between

the

> infusion of Oxaliplatin and the 5FU, what is the effect? Has this

> happened to anyone? Has anyone done any research on this?

>

> Thanks as always for your help.

>

> in California

[Guest guest]

Hi , when you say your sick from it do you mean vomitting /nausea sick

, or just allllllllll over sick?

When Joe had his treatment ( same as yours ) he got treatments Monday and was

S.I.C.K. til Friday at least. This went on for 5 months with them trying an

assortment of anti nausea meds until FINALLY they gave him Emend, morning

before treatment he would take a adavant, compazine and Emend , that was before

he even left for the chemo place, there he got anti nausea meds / plus a booster

shot of one , then his chemo , he was still sick til friday but minimum

vomitting on that

Deb

brencolinmom@... wrote:

Ingrid:

I was getting the 5FU bolus shot and then the 48 hour pump. However, they

have reduced my chemo 2 times: first they reduced it by 20% after I was in

the emergency room; then they took out the 5FU bolus shot because I was still

too sick. That was done for the first time last week. I just finished chemo

round 4 of 12 and I am so sick from it I can't get out of bed for at least 5

days. Then I am still sick until around day 7 or 8. Is this unusual??

Just a thought. But when I did chemo they usually gave a shot of 5-fu

before they started the pump. Did you get the bolos shot before they

forgot to start the pump? Ingrid

> Hi everyone:

>

> Last week was chemo week for me. It is supposed to be a 5 hour

> infusion at the oncologist's office beginning with pre-meds, then

> Avastin, followed by Oxaliplatin/Leucovorin. After that, I am

hooked

> up to the 48 hour pump with 5FU which I wear at home for the next 2

> days. Last Tuesday, they forgot to turn on my 48 hour pump when I

> left the office so I wore it thinking it was working for about 28

> hours. At that time, I saw something flashing in the upper right

> side of the pump and called the pump manufacturer only to find it

had

> not been turned on. I turned it on then and had to stay with the

> pump until 6 p.m. on Friday night.

>

> My question is this: I understood that Oxaliplatin/Leucovorin

needs

> to work together with 5FU to fight this cancer. That is, if used

> separately, Oxaliplatin doesn't work. If I went 28 hours between

the

> infusion of Oxaliplatin and the 5FU, what is the effect? Has this

> happened to anyone? Has anyone done any research on this?

>

> Thanks as always for your help.

>

> in California

[Guest guest]

Yes, I think that you are suffering more then most.

Have you discussed this with your ONC? Maybe they can give you

stronger anti-nausia medication.

I feel for you. I did not get real sick till the last four

treatments, but then still not as bad as you are having to endure.

Chemo does effect all differently. You sound like your system is

real sensitive to the chemo. But, you are getting some powerful

cancer-fighting chemo drugs. I am sending prayers up for you. Ingrid

> > Hi everyone:

> >

> > Last week was chemo week for me. It is supposed to be a 5 hour

> > infusion at the oncologist's office beginning with pre-meds,

then

> > Avastin, followed by Oxaliplatin/Leucovorin. After that, I am

> hooked

> > up to the 48 hour pump with 5FU which I wear at home for the

next 2

> > days. Last Tuesday, they forgot to turn on my 48 hour pump when

I

> > left the office so I wore it thinking it was working for about

28

> > hours. At that time, I saw something flashing in the upper

right

> > side of the pump and called the pump manufacturer only to find

it

> had

> > not been turned on. I turned it on then and had to stay with

the

> > pump until 6 p.m. on Friday night.

> >

> > My question is this: I understood that Oxaliplatin/Leucovorin

> needs

> > to work together with 5FU to fight this cancer. That is, if

used

> > separately, Oxaliplatin doesn't work. If I went 28 hours

between

> the

> > infusion of Oxaliplatin and the 5FU, what is the effect? Has

this

> > happened to anyone? Has anyone done any research on this?

> >

> > Thanks as always for your help.

> >

> > in California

>

>

>

>

>

[Guest guest]

Yes, I think that you are suffering more then most.

Have you discussed this with your ONC? Maybe they can give you

stronger anti-nausia medication.

I feel for you. I did not get real sick till the last four

treatments, but then still not as bad as you are having to endure.

Chemo does effect all differently. You sound like your system is

real sensitive to the chemo. But, you are getting some powerful

cancer-fighting chemo drugs. I am sending prayers up for you. Ingrid

> > Hi everyone:

> >

> > Last week was chemo week for me. It is supposed to be a 5 hour

> > infusion at the oncologist's office beginning with pre-meds,

then

> > Avastin, followed by Oxaliplatin/Leucovorin. After that, I am

> hooked

> > up to the 48 hour pump with 5FU which I wear at home for the

next 2

> > days. Last Tuesday, they forgot to turn on my 48 hour pump when

I

> > left the office so I wore it thinking it was working for about

28

> > hours. At that time, I saw something flashing in the upper

right

> > side of the pump and called the pump manufacturer only to find

it

> had

> > not been turned on. I turned it on then and had to stay with

the

> > pump until 6 p.m. on Friday night.

> >

> > My question is this: I understood that Oxaliplatin/Leucovorin

> needs

> > to work together with 5FU to fight this cancer. That is, if

used

> > separately, Oxaliplatin doesn't work. If I went 28 hours

between

> the

> > infusion of Oxaliplatin and the 5FU, what is the effect? Has

this

> > happened to anyone? Has anyone done any research on this?

> >

> > Thanks as always for your help.

> >

> > in California

>

>

>

>

>