DHEA bad reactions, sulfation problems, cysteine status

[Guest guest]

>

> > " people with defects in sulfation (a phase two reaction) are

likley

> to have an aberrant reaction to DHEA supplementation "

> > per AI Page 111

>

> > This concerned me more, because I am normal cysteine, eat sulfur

> > foods, but when I have tried NAC or MSM, I have had reactions to

> > them. Andy has said that is common/normal, to react more

strongly

> > to the supps than to food. So, if this would have only had the

> > broccoli, I was going to tell him to try it, but with the NAC

too,

> > I am more leary of it. -Jackie (from a different thread)

>

> From this discussion it would seem that I'm a person with " defects

in

> sulfation " . But I am just fine AFAIK with sulphury foods. I even

take

> NAC so that would mean I was " normal cysteine " .

>

> Are these two different concepts or?

-------Yes, these are two different concepts/issues. Usually we

talk about people being low sulfate and needing epsom salt baths,

etc., but in this case when Andy says *defects in sulfation*, I

don't think he means just low in sulfate (otherwise he would have

said that), I think he is referring to some problem with the

sulfation pathway in the liver, and sulfate is not being used, even

if it is available. So, I believe in this case, sulfate can

actually build up and become high. So this defect in sulfation is

what would cause your reaction to DHEA.

Now, sulfury foods and supplements have to do with your cysteine

status or levels, not with your sulfate levels. Andy says that

sulfate needs to go in as sulfate. So you tolerating sulfury foods

and supplements is a sign that you are probably either low or normal

cysteine, and this has nothing to do with your sulfate status.

We have had some recent discussions about these, if you search

archives, and post #57707 in A-M is a good one, and you will find it

as part of the onibasu/wiki cysteine status section. And DeanSA

also has some info on this at his webpage, and also check out pages

195-196 in AI.

Jackie

>

> ~robin

>

[Guest guest]

From AI page 40 " The liver converts all the millions of different

poisonous thing in the food we eat int a few chemicals the body likes " .

How the liver does this is with enzymes. From Wikipedia ,

> *Enzymes* are biomolecules http://en.wikipedia.org/wiki/Biomolecule>

> that catalyze http://en.wikipedia.org/wiki/Catalysis> (/i.e./

> accelerate http://en.wikipedia.org/wiki/Reaction_rate>) the rates of

> chemical reactions

> http://en.wikipedia.org/wiki/Chemical_reaction>.^[1]

> http://en.wikipedia.org/wiki/Enzymes#cite_note-0> ^[2]

> http://en.wikipedia.org/wiki/Enzymes#cite_note-1> Almost all enzymes

> are proteins http://en.wikipedia.org/wiki/Protein>.

The conversion process described by Andy (page 40) is accomplished by

an array of different enzymes, in a two step process , phase one and

phase two detoxification. Each of these " phases " include parallel detox

pathways each of which is governed or regulated by a specific enzyme.

One of the phase two pathways is known as sulfation (see page 42, 43);

impaired sulfation refers to this. Another pathway is the methylation

pathway. I'll never forget the first time an impaired methylation

pathway ruined my day.

I had a " routine " knee surgery . The anesthesiologist adds one of the

drugs from the botanical family ephedra to the local anesthetic to

enhance the effectiveness of the numbing agent. The dose of epinephrine

and the anesthetic were appropriate to my weight and height. I had

been numbed from the waist down and been told that I would " thaw out "

that is regain feeling in my lower extremities about one-two hours after

the surgery. Six hours later I was still unable to walk or urinate and

had to be catheterized to relieve the pressure on my bladder. Finally

10 hours after the surgery I was able to stand on my feet again.

I did not know anything about Amalgam Illness or impaired methylation at

the time. Here is the quote from AI on page 110 " " Impaired methylation

leads to slow clearance of epinephrine, norepinephrine and

dopamine...... " Page 110 in AI talks more about liver metabolism and

symptoms of insufficiency. Page 111 talks about the related but

different issue of sulfur metabolism.

The importance of the role of the liver in amalgam illness cannot be

underestimated. I think that many of our health and healing crisis's

great and small are a sign of bad reaction to or deficiency of some

substance and are often traceable to liver function or disfunction.

Genova Labs, formerly Great Smokies Diagnostics is a great source of

information on liver detox pathways.

http://genovadiagnostics.com/files/profile_assets/referenced_materials/Detox_Ap\

pGuide.pdf>

Some of the charts and information in AI comes directly from their

description of their oxidative stress test panel which many of us and

our doctors are familiar with.

Doug

[Guest guest]

From AI page 40 " The liver converts all the millions of different

poisonous thing in the food we eat int a few chemicals the body likes " .

How the liver does this is with enzymes. From Wikipedia ,

> *Enzymes* are biomolecules http://en.wikipedia.org/wiki/Biomolecule>

> that catalyze http://en.wikipedia.org/wiki/Catalysis> (/i.e./

> accelerate http://en.wikipedia.org/wiki/Reaction_rate>) the rates of

> chemical reactions

> http://en.wikipedia.org/wiki/Chemical_reaction>.^[1]

> http://en.wikipedia.org/wiki/Enzymes#cite_note-0> ^[2]

> http://en.wikipedia.org/wiki/Enzymes#cite_note-1> Almost all enzymes

> are proteins http://en.wikipedia.org/wiki/Protein>.

The conversion process described by Andy (page 40) is accomplished by

an array of different enzymes, in a two step process , phase one and

phase two detoxification. Each of these " phases " include parallel detox

pathways each of which is governed or regulated by a specific enzyme.

One of the phase two pathways is known as sulfation (see page 42, 43);

impaired sulfation refers to this. Another pathway is the methylation

pathway. I'll never forget the first time an impaired methylation

pathway ruined my day.

I had a " routine " knee surgery . The anesthesiologist adds one of the

drugs from the botanical family ephedra to the local anesthetic to

enhance the effectiveness of the numbing agent. The dose of epinephrine

and the anesthetic were appropriate to my weight and height. I had

been numbed from the waist down and been told that I would " thaw out "

that is regain feeling in my lower extremities about one-two hours after

the surgery. Six hours later I was still unable to walk or urinate and

had to be catheterized to relieve the pressure on my bladder. Finally

10 hours after the surgery I was able to stand on my feet again.

I did not know anything about Amalgam Illness or impaired methylation at

the time. Here is the quote from AI on page 110 " " Impaired methylation

leads to slow clearance of epinephrine, norepinephrine and

dopamine...... " Page 110 in AI talks more about liver metabolism and

symptoms of insufficiency. Page 111 talks about the related but

different issue of sulfur metabolism.

The importance of the role of the liver in amalgam illness cannot be

underestimated. I think that many of our health and healing crisis's

great and small are a sign of bad reaction to or deficiency of some

substance and are often traceable to liver function or disfunction.

Genova Labs, formerly Great Smokies Diagnostics is a great source of

information on liver detox pathways.

http://genovadiagnostics.com/files/profile_assets/referenced_materials/Detox_Ap\

pGuide.pdf>

Some of the charts and information in AI comes directly from their

description of their oxidative stress test panel which many of us and

our doctors are familiar with.

Doug

[Guest guest]

From AI page 40 " The liver converts all the millions of different

poisonous thing in the food we eat int a few chemicals the body likes " .

How the liver does this is with enzymes. From Wikipedia ,

> *Enzymes* are biomolecules http://en.wikipedia.org/wiki/Biomolecule>

> that catalyze http://en.wikipedia.org/wiki/Catalysis> (/i.e./

> accelerate http://en.wikipedia.org/wiki/Reaction_rate>) the rates of

> chemical reactions

> http://en.wikipedia.org/wiki/Chemical_reaction>.^[1]

> http://en.wikipedia.org/wiki/Enzymes#cite_note-0> ^[2]

> http://en.wikipedia.org/wiki/Enzymes#cite_note-1> Almost all enzymes

> are proteins http://en.wikipedia.org/wiki/Protein>.

The conversion process described by Andy (page 40) is accomplished by

an array of different enzymes, in a two step process , phase one and

phase two detoxification. Each of these " phases " include parallel detox

pathways each of which is governed or regulated by a specific enzyme.

One of the phase two pathways is known as sulfation (see page 42, 43);

impaired sulfation refers to this. Another pathway is the methylation

pathway. I'll never forget the first time an impaired methylation

pathway ruined my day.

I had a " routine " knee surgery . The anesthesiologist adds one of the

drugs from the botanical family ephedra to the local anesthetic to

enhance the effectiveness of the numbing agent. The dose of epinephrine

and the anesthetic were appropriate to my weight and height. I had

been numbed from the waist down and been told that I would " thaw out "

that is regain feeling in my lower extremities about one-two hours after

the surgery. Six hours later I was still unable to walk or urinate and

had to be catheterized to relieve the pressure on my bladder. Finally

10 hours after the surgery I was able to stand on my feet again.

I did not know anything about Amalgam Illness or impaired methylation at

the time. Here is the quote from AI on page 110 " " Impaired methylation

leads to slow clearance of epinephrine, norepinephrine and

dopamine...... " Page 110 in AI talks more about liver metabolism and

symptoms of insufficiency. Page 111 talks about the related but

different issue of sulfur metabolism.

The importance of the role of the liver in amalgam illness cannot be

underestimated. I think that many of our health and healing crisis's

great and small are a sign of bad reaction to or deficiency of some

substance and are often traceable to liver function or disfunction.

Genova Labs, formerly Great Smokies Diagnostics is a great source of

information on liver detox pathways.

http://genovadiagnostics.com/files/profile_assets/referenced_materials/Detox_Ap\

pGuide.pdf>

Some of the charts and information in AI comes directly from their

description of their oxidative stress test panel which many of us and

our doctors are familiar with.

Doug