Re: T4 Conversion to T3

[Guest guest]

" vscottbo " wrote:

>

> Since I am considering trying Block and Replace, am I correct to

> assume that I would need to take Thyroxine only and not T3 if my lab

> results show a very high FT3 number, like 1227, for example? I am

> trying to work out all the details, myself, since I am having my GP

> monitor me on Methimazole, and I know he has had no experience with

> B&R.

If you have a very high fT3 you don't replace yet, you don't

need to.

Taking thyroxine whilst your fT3 is so high would be dangerous!

If you look at the algorithmn for drug treatment of

hyperthyroidism at www.thyroidmanager.org, it suggests a point

in the treatment regime where you either reduce antithyroid

drug, or supplement with thyroxine, depending on your intended

treatment method -- it might be a bit conservative but

conservative is generally good for the individual patient, if

not for advancing medical knowledge.

Block and Replace was originally done with T3, and only later

with thyroxine, I know as I queried Elaines mention of T3 in her

book (Graves Disease a Practical Guide, which references

Yamamoto M. et al, Clinical Endocrinlogy 1983 19 467-476).

A proper look at recent papers referencing this one should get

your doctor plenty of material on B&R.

Don't forget the archive.....

My endo isn't keen on B&R, although the paper he mentioned did

show good results with B&R, just no statistically significant

increase in remissions (at 5% significance level). My reading

suggested the increased remissions with B&R had only a 1 in 5

probability of being due to chance, but modern medicine is madly

in love with outcomes that have only a 1 in 20 probability of

being due to chance.

Ho hum, that is the way the statistical cookies crumble

[Guest guest]

Hello, Simon,

You wrote: Taking thyroxine whilst your fT3 is so high would be

dangerous!

I didn't mean that I was going to replace with thyroxine, now. I

didn't make that clear. I meant that when my lab results show the

overproduction of thyroid hormones to be blocked, that I would, then,

replace with thyroxine. I have read, here, about some people taking

T3 and I didn't know when that came into play.

If it turns out my GP isn't comfortable with B&R, I will take the

regular course of action and just reduce the Methimazole as the lab

results indicate it is time to do so.

Thank you for you information. I will research more after the

holidays.

[Guest guest]

Hello, Simon,

You wrote: Taking thyroxine whilst your fT3 is so high would be

dangerous!

I didn't mean that I was going to replace with thyroxine, now. I

didn't make that clear. I meant that when my lab results show the

overproduction of thyroid hormones to be blocked, that I would, then,

replace with thyroxine. I have read, here, about some people taking

T3 and I didn't know when that came into play.

If it turns out my GP isn't comfortable with B&R, I will take the

regular course of action and just reduce the Methimazole as the lab

results indicate it is time to do so.

Thank you for you information. I will research more after the

holidays.