Re: APOE and Mercury accumulation?

[Guest guest]

This is interesting. I was looking at some abstracts I wanted to

find the full articles for and I came accross this one.

Dietary Alpha-Lipoic Acid Supplementation Inhibits Atherosclerotic

Lesion Development in Apolipoprotein E–Deficient and Apolipoprotein

E/Low-Density Lipoprotein Receptor–Deficient Mice

http://circ.ahajournals.org/cgi/content/abstract/CIRCULATIONAHA.107.72

5275v1

>

> I was wondering if Andy mentioned anything about APOE and mercury

> accumulation? I started getting some family history of disease and

> started wondering about Alzhemers (sp), my great grandmother had

> this, and there have been quite a few with cancer and heart

issues.

> Well, in this research I came across a link between Alzhemers and

> Heart disease, related to APO-E specifically 3 and 4 version of

this

> gene. According to one article I read they mentioned that mercury

> and other heavy metal accumulation was related to this gene. Ok,

> that's all fine and dandy, but then I looked more and I see it

linked

> to hyperlipidemia, not something that I have had problems with

(that

> I know of) but I did develop a xanthoma on my eyelid that can be

> associated with hyperlipidemia. I had wondered why I developed

this

> xanthoma, as it is rare and is normally associated with very high

> lipid levels (though it is also liked to a messed up lipid

> metabolism). I wonder if perhaps I might have this gene, so I

> wondered if Andy or someone else has looked at this? I did a

search

> and only found 1 person mentioning this gene, way back a few years

> ago, but nothing else was talked about with regards to this.

>

> So to make a long message short, has Andy mentioned anything about

> this? I wonder if perhaps I should get this gene tested for. Not

> that I can do anything about it besides stearing clear of heavy

metal

> accumulation as much as I can.

>

> Another related question, is this group ok to ask research type

> questions on or should I just email Andy or someone else directly?

> Seems a few questions like this that I've had have either been

> ignored or thought negatively of. I'm an engineer type person and

> like to take things apart and explore all things regarding it, but

I

> don't want to break too much apart from the protocol that Andy has

> put forth for us. (Or question the mechanisms behind it.) I put

> Andy in the highest regard and only ask questions to learn more for

> myself, I love learning more about how the body works, probably a

bit

> too much at times.

>

> Thanks,

> Mike

>