Re: found some info about ALA - mercury

[Guest guest]

The whole article is in the files section of autism mercury. I asked

for permission to post it in our files, was told to wait until it hit

the press, and haven't had a chance to put it there yet.

J

>

> source:

>

http://www.ncbi.nlm.nih.gov/pubmed/17408840?ordinalpos=1&itool=EntrezSystem2.PEn\

trez.Pubmed.Pubmed_ResultsPanel.Pubmed_RVDocSum

>

>

>

>

> Rooney JP.

>

> Centre for Synthesis and Chemical Biology, Department of

> Pharmaceutical and Medicinal Chemistry, Royal College of Surgeons in

> Ireland, Dublin 2, Ireland. jrooney@...

>

> Mercury has been a known as a toxic substance for centuries. Whilst

> the clinical features of acute mercury poisoning have been well

> described, chronic low dose exposure to mercury remains poorly

> characterised and its potential role in various chronic disease states

> remains controversial. Low molecular weight thiols, i.e. sulfhydryl

> containing molecules such as cysteine, are emerging as important

> factors in the transport and distribution of mercury throughout the

> body due to the phenomenon of " Molecular Mimicry " and its role in the

> molecular transport of mercury. Chelation agents such as the dithiols

> sodium 2,3-dimercaptopropanesulfate (DMPS) and

> meso-2,3-dimercaptosuccinic acid (DMSA) are the treatments of choice

> for mercury toxicity. Alpha-lipoic acid (ALA), a disulfide, and its

> metabolite dihydrolipoic acid (DHLA), a dithiol, have also been shown

> to have chelation properties when used in an appropriate manner.

> Whilst N-acetyl-cysteine (NAC) and glutathione (GSH) have been

> recommended in the treatment of mercury toxicity in the past, an

> examination of available evidence suggests these agents may in fact be

> counterproductive. Zinc and selenium have also been shown to exert

> protective effects against mercury toxicity, most likely mediated by

> induction of the metal binding proteins metallothionein and

> selenoprotein-P. Evidence suggests however that the co-administration

> of selenium and dithiol chelation agents during treatment may also be

> counter-productive. Finally, the issue of diagnostic testing for

> chronic, historical or low dose mercury poisoning is considered

> including an analysis of the influence of ligand interactions and

> nutritional factors upon the accuracy of " chelation challenge " tests.

>

> PMID: 17408840 [PubMed - indexed for MEDLINE]

>

> I found this very important sentence that Mr Cutler must

> have repeated a thousand times by now.

>

> ''Alpha-lipoic acid (ALA), a disulfide, and its metabolite

> dihydrolipoic acid (DHLA), a dithiol, have also been shown to have

> chelation properties WHEN USED IN AN APPROPIATE MANNER.

>

> Also is written in this abstract that NAC and GSH can be

> counterproductive in mercury toxicity. Andy you will read

> so many phony experts(like Dr Mercola) on internet recomending

> NAC,GSH, Chlorella etc... Shame on them!

>

> Greetings Ali

>

[Guest guest]

The whole article is in the files section of autism mercury. I asked

for permission to post it in our files, was told to wait until it hit

the press, and haven't had a chance to put it there yet.

J

>

> source:

>

http://www.ncbi.nlm.nih.gov/pubmed/17408840?ordinalpos=1&itool=EntrezSystem2.PEn\

trez.Pubmed.Pubmed_ResultsPanel.Pubmed_RVDocSum

>

>

>

>

> Rooney JP.

>

> Centre for Synthesis and Chemical Biology, Department of

> Pharmaceutical and Medicinal Chemistry, Royal College of Surgeons in

> Ireland, Dublin 2, Ireland. jrooney@...

>

> Mercury has been a known as a toxic substance for centuries. Whilst

> the clinical features of acute mercury poisoning have been well

> described, chronic low dose exposure to mercury remains poorly

> characterised and its potential role in various chronic disease states

> remains controversial. Low molecular weight thiols, i.e. sulfhydryl

> containing molecules such as cysteine, are emerging as important

> factors in the transport and distribution of mercury throughout the

> body due to the phenomenon of " Molecular Mimicry " and its role in the

> molecular transport of mercury. Chelation agents such as the dithiols

> sodium 2,3-dimercaptopropanesulfate (DMPS) and

> meso-2,3-dimercaptosuccinic acid (DMSA) are the treatments of choice

> for mercury toxicity. Alpha-lipoic acid (ALA), a disulfide, and its

> metabolite dihydrolipoic acid (DHLA), a dithiol, have also been shown

> to have chelation properties when used in an appropriate manner.

> Whilst N-acetyl-cysteine (NAC) and glutathione (GSH) have been

> recommended in the treatment of mercury toxicity in the past, an

> examination of available evidence suggests these agents may in fact be

> counterproductive. Zinc and selenium have also been shown to exert

> protective effects against mercury toxicity, most likely mediated by

> induction of the metal binding proteins metallothionein and

> selenoprotein-P. Evidence suggests however that the co-administration

> of selenium and dithiol chelation agents during treatment may also be

> counter-productive. Finally, the issue of diagnostic testing for

> chronic, historical or low dose mercury poisoning is considered

> including an analysis of the influence of ligand interactions and

> nutritional factors upon the accuracy of " chelation challenge " tests.

>

> PMID: 17408840 [PubMed - indexed for MEDLINE]

>

> I found this very important sentence that Mr Cutler must

> have repeated a thousand times by now.

>

> ''Alpha-lipoic acid (ALA), a disulfide, and its metabolite

> dihydrolipoic acid (DHLA), a dithiol, have also been shown to have

> chelation properties WHEN USED IN AN APPROPIATE MANNER.

>

> Also is written in this abstract that NAC and GSH can be

> counterproductive in mercury toxicity. Andy you will read

> so many phony experts(like Dr Mercola) on internet recomending

> NAC,GSH, Chlorella etc... Shame on them!

>

> Greetings Ali

>

[Guest guest]

The whole article is in the files section of autism mercury. I asked

for permission to post it in our files, was told to wait until it hit

the press, and haven't had a chance to put it there yet.

J

>

> source:

>

http://www.ncbi.nlm.nih.gov/pubmed/17408840?ordinalpos=1&itool=EntrezSystem2.PEn\

trez.Pubmed.Pubmed_ResultsPanel.Pubmed_RVDocSum

>

>

>

>

> Rooney JP.

>

> Centre for Synthesis and Chemical Biology, Department of

> Pharmaceutical and Medicinal Chemistry, Royal College of Surgeons in

> Ireland, Dublin 2, Ireland. jrooney@...

>

> Mercury has been a known as a toxic substance for centuries. Whilst

> the clinical features of acute mercury poisoning have been well

> described, chronic low dose exposure to mercury remains poorly

> characterised and its potential role in various chronic disease states

> remains controversial. Low molecular weight thiols, i.e. sulfhydryl

> containing molecules such as cysteine, are emerging as important

> factors in the transport and distribution of mercury throughout the

> body due to the phenomenon of " Molecular Mimicry " and its role in the

> molecular transport of mercury. Chelation agents such as the dithiols

> sodium 2,3-dimercaptopropanesulfate (DMPS) and

> meso-2,3-dimercaptosuccinic acid (DMSA) are the treatments of choice

> for mercury toxicity. Alpha-lipoic acid (ALA), a disulfide, and its

> metabolite dihydrolipoic acid (DHLA), a dithiol, have also been shown

> to have chelation properties when used in an appropriate manner.

> Whilst N-acetyl-cysteine (NAC) and glutathione (GSH) have been

> recommended in the treatment of mercury toxicity in the past, an

> examination of available evidence suggests these agents may in fact be

> counterproductive. Zinc and selenium have also been shown to exert

> protective effects against mercury toxicity, most likely mediated by

> induction of the metal binding proteins metallothionein and

> selenoprotein-P. Evidence suggests however that the co-administration

> of selenium and dithiol chelation agents during treatment may also be

> counter-productive. Finally, the issue of diagnostic testing for

> chronic, historical or low dose mercury poisoning is considered

> including an analysis of the influence of ligand interactions and

> nutritional factors upon the accuracy of " chelation challenge " tests.

>

> PMID: 17408840 [PubMed - indexed for MEDLINE]

>

> I found this very important sentence that Mr Cutler must

> have repeated a thousand times by now.

>

> ''Alpha-lipoic acid (ALA), a disulfide, and its metabolite

> dihydrolipoic acid (DHLA), a dithiol, have also been shown to have

> chelation properties WHEN USED IN AN APPROPIATE MANNER.

>

> Also is written in this abstract that NAC and GSH can be

> counterproductive in mercury toxicity. Andy you will read

> so many phony experts(like Dr Mercola) on internet recomending

> NAC,GSH, Chlorella etc... Shame on them!

>

> Greetings Ali

>

[Guest guest]

, do you mind explaning what this could mean, you seem very

knowledgeable about mercury etc " Vitamin C, glutathione, or lipoic

acid did not decrease brain or kidney mercury in rats exposed to

mercury vapor. This was one of the side articles in the link you

provided. Thanks greatly appreciated.

> >

> > source:

> >

>

http://www.ncbi.nlm.nih.gov/pubmed/17408840?ordinalpos=1&itool=EntrezSystem2.PEn\

trez.Pubmed.Pubmed_ResultsPanel.Pubmed_RVDocSum

> >

> >

> >

> >

>