found some info about ALA - mercury

[Guest guest]

source:

http://www.ncbi.nlm.nih.gov/pubmed/17408840?ordinalpos=1&itool=EntrezSystem2.PEn\

trez.Pubmed.Pubmed_ResultsPanel.Pubmed_RVDocSum

Rooney JP.

Centre for Synthesis and Chemical Biology, Department of

Pharmaceutical and Medicinal Chemistry, Royal College of Surgeons in

Ireland, Dublin 2, Ireland. jrooney@...

Mercury has been a known as a toxic substance for centuries. Whilst

the clinical features of acute mercury poisoning have been well

described, chronic low dose exposure to mercury remains poorly

characterised and its potential role in various chronic disease states

remains controversial. Low molecular weight thiols, i.e. sulfhydryl

containing molecules such as cysteine, are emerging as important

factors in the transport and distribution of mercury throughout the

body due to the phenomenon of " Molecular Mimicry " and its role in the

molecular transport of mercury. Chelation agents such as the dithiols

sodium 2,3-dimercaptopropanesulfate (DMPS) and

meso-2,3-dimercaptosuccinic acid (DMSA) are the treatments of choice

for mercury toxicity. Alpha-lipoic acid (ALA), a disulfide, and its

metabolite dihydrolipoic acid (DHLA), a dithiol, have also been shown

to have chelation properties when used in an appropriate manner.

Whilst N-acetyl-cysteine (NAC) and glutathione (GSH) have been

recommended in the treatment of mercury toxicity in the past, an

examination of available evidence suggests these agents may in fact be

counterproductive. Zinc and selenium have also been shown to exert

protective effects against mercury toxicity, most likely mediated by

induction of the metal binding proteins metallothionein and

selenoprotein-P. Evidence suggests however that the co-administration

of selenium and dithiol chelation agents during treatment may also be

counter-productive. Finally, the issue of diagnostic testing for

chronic, historical or low dose mercury poisoning is considered

including an analysis of the influence of ligand interactions and

nutritional factors upon the accuracy of " chelation challenge " tests.

PMID: 17408840 [PubMed - indexed for MEDLINE]

I found this very important sentence that Mr Cutler must

have repeated a thousand times by now.

''Alpha-lipoic acid (ALA), a disulfide, and its metabolite

dihydrolipoic acid (DHLA), a dithiol, have also been shown to have

chelation properties WHEN USED IN AN APPROPIATE MANNER.

Also is written in this abstract that NAC and GSH can be

counterproductive in mercury toxicity. Andy you will read

so many phony experts(like Dr Mercola) on internet recomending

NAC,GSH, Chlorella etc... Shame on them!

Greetings Ali