Irreversible Damage in Multiple Sclerosis

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http://www.healthnewsdigest.com/news/hlth_ms-11.html

.... Yale researchers and collaborators have identified molecules that

underlie nerve fiber degeneration in patients with secondary progressive

multiple sclerosis (MS), ... found a strong link between nerve damage and

the presence of two molecules, Nav. 1.6 and NCX, a sodium channel and a

sodium-calcium exchanger.

Located on the surface of most nerve fibers, Nav.1.6 controls the flow of

sodium into the cell, which in turn triggers the activation of NCX, a

molecule that, if unchecked, imports abnormal levels of calcium into the

nerve fiber that ultimately lead to its death. ...