Ibuprofen Treatment May Reduce Synovium and Cartilage Turnover in Inflammatory Knee Osteoarthritis

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Ibuprofen Treatment May Reduce Synovium and Cartilage Turnover in

Inflammatory Knee Osteoarthritis

ls of the Rheumatic Diseases (ARD Online)

07/01/2004

By Jill

High doses of ibuprofen appear to reduce the turnover of synovium and

cartilage in patients with osteoarthritis (OA), especially those with

clinical

evidence of synovitis, French researchers have found.

OA is characterised by degraded articular cartilage and alteration of

synovium and subchondral bone metabolism, leading to joint pain and

stiffness.

Non-steroidal anti-inflammatory drugs (NSAIDs), such as ibuprofen, are

commonly used

to alleviate pain associated with OA, but their effects on cartilage and

synovium metabolism are unclear.

To assess effect of ibuprofen on the turnover of cartilage and synovial

tissue matrices in patients with OA, researchers led by e Gineyts,

PhD, of

INSERM Research Unit 403, Lyon, France, performed a study in which they

evaluated changes in 2 molecular markers of cartilage and synovial tissue

metabolism,

C-terminal crosslinking telopeptide of type II collagen (CTX-II) and urinary

glucosyl galactosyl pyridinoline (Glc-Gal-PYD).

The study population consisted of 201 patients with Š

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