Re: New PSC leads

[Guest guest]

Thanks for that wonderful explanation Dave. In addition, I googled

" methylamine, " and found this free-use abstract regarding cigarette

smoking and methylamine. Another reason for PSCers not to smoke? But

then I'm confused, as I thought smokers were less likely to get PSC than

non-smokers? .

1) Neuropsychiatry Research Unit, Department of Psychiatry, University

of Saskatchewan, Saskatoon, Saskatchewan, Canada, S7N 5E4.

Abstract Methylamine is a constituent of cigarette smoke and the major

end product of nicotine metabolism. Smoking or nicotine can induce the

release of adrenaline, which is in turn deaminated by monoamine oxidase,

also producing methylamine. We found that the urinary level of

methylamine was significantly elevated following administration of

nicotine (25 mg/Kg, i.p.). Semicarbazide-sensitive amine oxidase (SSAO)

inhibitors further increased the excretion of methylamine induced by

nicotine. Following administration of L-(—)-[N-methyl-3H]nicotine

long-lasting irreversible radioactive adducts were detected in different

mouse tissues and such adduct formation could be blocked by selective

SSAO inhibitors. These adducts are probably cross-linked oligoprotein

complexes cross-linked by formaldehyde. The findings support the idea

that nicotine can enhance SSAO/methylamine-mediated increase of

formaldehyde and oxidative stress and this could in part contribute the

adverse effect of health associated with smoking.

http://www.springerlink.com/content/m72935j154766688/

[Guest guest]

-----Original Message-----

Another reason for PSCer's not to smoke? But then I'm confused, as I

thought smokers were less likely to get PSC than non-smokers?

I think the original " smoking gun " study said UC was less likely in

smokers. Later another study (if I remember it right and who the heck

knows what I remember any more) just followed that same connection from:

smoking means less UC -to- smoking = less UC = less PSC (meaning no UC,

no PSC)

*IF* I am remembering it correctly.

Barb in Texas - Together in the Fight - Whatever it Takes!

Son Ken (34) UC 91 PSC 99, LTX 6/21 & 6/30 2007 @ Baylor/Dallas

[Guest guest]

-----Original Message-----

Another reason for PSCer's not to smoke? But then I'm confused, as I

thought smokers were less likely to get PSC than non-smokers?

I think the original " smoking gun " study said UC was less likely in

smokers. Later another study (if I remember it right and who the heck

knows what I remember any more) just followed that same connection from:

smoking means less UC -to- smoking = less UC = less PSC (meaning no UC,

no PSC)

*IF* I am remembering it correctly.

Barb in Texas - Together in the Fight - Whatever it Takes!

Son Ken (34) UC 91 PSC 99, LTX 6/21 & 6/30 2007 @ Baylor/Dallas