News to me - reversing PSC, Stanford U Study

[Guest guest]

I don't know if anyone has heard/read about this already, but

yesterday I was visiting a pediatric gastroenerologist to treat my

daughter for tummy problems and when she read I had a history of PSC

she turned me onto this treatment out of Stanford Univ that reversed

PSC with the use of vancomycin...hope this is helpful...

Davies YK, KM, Abdullah BA, Safta A, Terry AB, KL.

Department of Pediatrics, Lucile Packard Children's Hospital,

Stanford University, Palo Alto, CA 94304, USA.

BACKGROUND: Primary sclerosing cholangitis is a rare chronic

cholestatic condition of unknown etiology, frequently associated with

inflammatory bowel disease and characterized by diffuse fibrosing and

inflammatory destruction of the intra- and/or extrahepatic biliary

duct system. PATIENTS AND METHODS: The study involved 14 children

with primary sclerosing cholangitis confirmed by either liver biopsy,

endoscopic retrograde cholangiopancreatography, and/or magnetic

resonance cholangiogram. In each of the 14 cases, liver histology

showed characteristic features consistent with primary sclerosing

cholangitis. Eleven children had intrahepatic biliary beading and

strictures (6 by endoscopic retrograde cholangiopancreatography; 5 by

magnetic resonance cholangiogram). Biochemical tests of liver

function including alanine aminotransferase, aspartate

aminotransferase, and gamma-glutamyl transpeptidase and the

erythrocyte sedimentation rate were elevated for a mean 17 +/- 22

months before vancomycin treatment was initiated. All of the patients

were shown to have inflammatory bowel disease histologically; 13 of

those patients had clinical evidence of colitis. Oral vancomycin was

given to all 14 patients. RESULTS: All 14 patients showed improvement

in their alanine aminotransferase (P = 0.007), gamma-glutamyl

transpeptidase (P = 0.005), erythrocyte sedimentation rate (P =

0.008), and clinical symptoms with oral vancomycin treatment. There

was less improvement noted in the patients with cirrhosis when

compared with the patients without cirrhosis. CONCLUSIONS: Before

this study, there has not been an effective long-term treatment for

sclerosing cholangitis to prevent the usual progression of this

disease to cirrhosis. This study showed that oral vancomycin could be

an effective long-term treatment of sclerosing cholangitis in

children, especially those without cirrhosis.

[Guest guest]

Does anyone in this group take that oral medicine?

Lori A.

"Aggressively Pursuing Solutions To Your Real Estate Needs!"

First Weber Group

Cell:

1507 E. Sunset Drive

Waukesha, WI 53189

LoriUSA@...

www.Lori.FirstWeber.com

To: Sent: Thursday, November 13, 2008 8:33:20 AMSubject: Re: News to me - reversing PSC, Stanford U Study

This would appear to provide more ammunition for the theory that pediatric PSC is NOT the same PSC as adults get. I think I first heard that at the last PSC-partners conference.Arne---- Barbara Webber <bwebber01 (AT) yahoo (DOT) com> wrote: ...This study showed that oral vancomycin could be an effective long-term treatment of sclerosing cholangitis in children, especially those without cirrhosis.

[Guest guest]

Does anyone in this group take that oral medicine?

Lori A.

"Aggressively Pursuing Solutions To Your Real Estate Needs!"

First Weber Group

Cell:

1507 E. Sunset Drive

Waukesha, WI 53189

LoriUSA@...

www.Lori.FirstWeber.com

To: Sent: Thursday, November 13, 2008 8:33:20 AMSubject: Re: News to me - reversing PSC, Stanford U Study

This would appear to provide more ammunition for the theory that pediatric PSC is NOT the same PSC as adults get. I think I first heard that at the last PSC-partners conference.Arne---- Barbara Webber <bwebber01 (AT) yahoo (DOT) com> wrote: ...This study showed that oral vancomycin could be an effective long-term treatment of sclerosing cholangitis in children, especially those without cirrhosis.

[Guest guest]

Why is it restricted to children with PSC. I would think either you have PSC or you don't. Have they even tried it on adults or plan to?

Lori A.

"Aggressively Pursuing Solutions To Your Real Estate Needs!"

First Weber Group

Cell:

1507 E. Sunset Drive

Waukesha, WI 53189

LoriUSA@...

www.Lori.FirstWeber.com

To: Sent: Thursday, November 13, 2008 9:59:35 AMSubject: Re: News to me - reversing PSC, Stanford U Study

> > ...This study showed that oral vancomycin could be > an effective long-term treatment of sclerosing cholangitis in > children, especially those without cirrhosis.>

[Guest guest]

>

> Why is it restricted to children with PSC. I would think either you

have PSC or you don't. Have they even tried it on adults or plan to?

>

> Lori A.

The reason this particular study is for pediatric patients is because

a pediatric GI is running the study. posted this though and it

sounds like someone will be doing a study soon for adults.

" However, PSC Partners Seeking a Cure will have an announcement about

> a new vancomycin trial in adult PSC patients soon. Please keep an eye

> open for this announcement; we'll try to post this on the PSC

> Partners Seeking a Cure web site (www.pscpartners. org) and the

> newsletter as soon as it becomes available. "

Lori

lucky mom blessed with triplets

>

>

>

> ________________________________

[Guest guest]

>

> Why is it restricted to children with PSC. I would think either you

have PSC or you don't. Have they even tried it on adults or plan to?

>

> Lori A.

The reason this particular study is for pediatric patients is because

a pediatric GI is running the study. posted this though and it

sounds like someone will be doing a study soon for adults.

" However, PSC Partners Seeking a Cure will have an announcement about

> a new vancomycin trial in adult PSC patients soon. Please keep an eye

> open for this announcement; we'll try to post this on the PSC

> Partners Seeking a Cure web site (www.pscpartners. org) and the

> newsletter as soon as it becomes available. "

Lori

lucky mom blessed with triplets

>

>

>

> ________________________________