Guest guest Posted February 21, 2005 Report Share Posted February 21, 2005 Thyroid hormone replacement therapy. http://www.ncbi.nlm.nih.gov/entrez/query fcgi?cmd=Retrieve&db=PubMed&list_uids=11786691&dopt=Abstract Wiersinga WM. Department of Endocrinology and Metabolism, Academic Medical Centre, University of Amsterdam, NL-1105 AZ Amsterdam, The Netherlands. w.m wiersinga@... >>>>snip recent animal experiments indicate that only the combination of T(4) and T(3) replacement, and not T(4) alone, ensures euthyroidism in all tissues of thyroidectomized rats. It is indeed the experience of many physicians that there exists a small subset of hypothyroid patients who, despite biochemical euthyroidism, continue to complain of tiredness, lack of energy, discrete cognitive disorders and mood disturbances. As organs vary in the extent to which their T(3) content is derived from serum T(3) or locally produced T(3) from T(4), these complaints may have a biologic substrate; for example, brain T(3) content is largely determined by local deiodinase type II activity. Against this background it is of interest that a number of psychometric scores improved significantly in hypothyroid patients upon substitution of 50 microg of their T(4) replacement dose by 12.5 microg T(3) Confirmatory studies on this issue are urgently awaited. It could well be that a slow-release preparation containing both T(4) and T(3) might improve the quality of life, compared with T(4) replacement alone, in some hypothyroid patients. Copyright 2001 S. Karger AG, Basel Thyroid-Adrenal Connection: Information and Resources http://www.bestweb.net/~om/thyroid Jump for Joy ~ Rebound: have FUN while you exercise! http://www.bestweb.net/~om/rebound Quote Link to comment Share on other sites More sharing options...
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