Re: does liver disease cause clotting issues?

[Guest guest]

My understanding is that it does not, that as the disease progresses

it actually increases our clotting time placing us at risk for

bleeding concerns with surgries and such. They almost did not do my

last biopsy because my PT/PTT number was to high and they were

concerned about my risk of bleeding. My PCP also through a fit before

I had one surgery because the surgeon didn't order my clotting time to

be tested and then he explained to me the risk of bleeding with liver

disease.

Below is a link that explains it a little better

http://www.liverdisease.com/clotting_hepatitis.html

>

> is there a correlation with liver diseases and coagulation issues?

can it cause wide spread clotting stuff? like in the brain?

>

> Hall

>

> PSC, Raynauds, Hypothyroid, Chiari Malformation, Hypopituitary,

Secondary Adrenal Insufficiency, Bilateral Thansverse Sinus Stenosis, ?

Thromophilia

>

> www.caringbridge.org/visit/melissahall

>

[Guest guest]

Hi ;

Chronic liver disease, inflammatory bowel disease, and a number of

other diseases can often result in increased risk of blood clotting.

This may be because these diseases cause an increase of serum

homocysteine, which is a risk factor for blood clots:

Clotting Disorders

http://www.merck.com/mmpe/sec11/ch136/ch136a.html

" A high level of homocysteine in the blood (hyperhomocysteinemia) makes

the blood in veins and especially arteries more likely to clot. A high

level may result from a hereditary disorder or a deficiency of vitamin

B6, vitamin B12, or folic acid. "

There is much evidence that inflammatory bowel disease and chronic

liver disease can result in elevated homocysteine and increased risk of

blood clotting (hypercoagulation) ... see for example:

Biagini MR, Tozzi A, Marcucci R, Paniccia R, Fedi S, Milani S, Galli A,

Ceni E, Capanni M, Manta R, Abbate R, Surrenti C 2006

Hyperhomocysteinemia and hypercoagulability in primary biliary

cirrhosis. World J. Gastroenterol. 12: 1607-1612.

http://www.ncbi.nlm.nih.gov/pubmed/16570355

Bosy-Westphal A, sen S, Hinrichsen H, Czech N, J Muller M 2001

Increased plasma homocysteine in liver cirrhosis. Hepatol. Res. 20: 28-

38.

http://www.ncbi.nlm.nih.gov/pubmed/11282484

Cattaneo M, Vecchi M, Zighetti ML, Saibeni S, elli I, Omodei P,

Mannucci PM, de Franchis R 1998 High prevalence of

hyperchomocysteinemia in patients with inflammatory bowel disease: a

pathogenic link with thromboembolic complications? Thromb. Haemost. 80:

542-545.

http://www.ncbi.nlm.nih.gov/pubmed/9798965

Koutroubakis IE 2005 Therapy insight: vascular complications in

patients with inflammatory bowel disease. Nat. Clin. Pract.

Gastroenterol. Hepatol. 2: 266-272.

http://www.ncbi.nlm.nih.gov/pubmed/16265230

To try to minimize this risk, our son takes folic acid supplements. And

we encourage him to eat spinach rather than lettuce in salads. Spinach

is rich in betaine, which helps lower homocysteine.

Best regards,

Dave

(father of (23); PSC 07/03; UC 08/03)

>

> is there a correlation with liver diseases and coagulation issues?

can it cause wide spread clotting stuff? like in the brain?

>

> Hall

>

> PSC, Raynauds, Hypothyroid, Chiari Malformation, Hypopituitary,

Secondary Adrenal Insufficiency, Bilateral Thansverse Sinus Stenosis, ?

Thromophilia

>

> www.caringbridge.org/visit/melissahall

>

[Guest guest]

Hi ;

Chronic liver disease, inflammatory bowel disease, and a number of

other diseases can often result in increased risk of blood clotting.

This may be because these diseases cause an increase of serum

homocysteine, which is a risk factor for blood clots:

Clotting Disorders

http://www.merck.com/mmpe/sec11/ch136/ch136a.html

" A high level of homocysteine in the blood (hyperhomocysteinemia) makes

the blood in veins and especially arteries more likely to clot. A high

level may result from a hereditary disorder or a deficiency of vitamin

B6, vitamin B12, or folic acid. "

There is much evidence that inflammatory bowel disease and chronic

liver disease can result in elevated homocysteine and increased risk of

blood clotting (hypercoagulation) ... see for example:

Biagini MR, Tozzi A, Marcucci R, Paniccia R, Fedi S, Milani S, Galli A,

Ceni E, Capanni M, Manta R, Abbate R, Surrenti C 2006

Hyperhomocysteinemia and hypercoagulability in primary biliary

cirrhosis. World J. Gastroenterol. 12: 1607-1612.

http://www.ncbi.nlm.nih.gov/pubmed/16570355

Bosy-Westphal A, sen S, Hinrichsen H, Czech N, J Muller M 2001

Increased plasma homocysteine in liver cirrhosis. Hepatol. Res. 20: 28-

38.

http://www.ncbi.nlm.nih.gov/pubmed/11282484

Cattaneo M, Vecchi M, Zighetti ML, Saibeni S, elli I, Omodei P,

Mannucci PM, de Franchis R 1998 High prevalence of

hyperchomocysteinemia in patients with inflammatory bowel disease: a

pathogenic link with thromboembolic complications? Thromb. Haemost. 80:

542-545.

http://www.ncbi.nlm.nih.gov/pubmed/9798965

Koutroubakis IE 2005 Therapy insight: vascular complications in

patients with inflammatory bowel disease. Nat. Clin. Pract.

Gastroenterol. Hepatol. 2: 266-272.

http://www.ncbi.nlm.nih.gov/pubmed/16265230

To try to minimize this risk, our son takes folic acid supplements. And

we encourage him to eat spinach rather than lettuce in salads. Spinach

is rich in betaine, which helps lower homocysteine.

Best regards,

Dave

(father of (23); PSC 07/03; UC 08/03)

>

> is there a correlation with liver diseases and coagulation issues?

can it cause wide spread clotting stuff? like in the brain?

>

> Hall

>

> PSC, Raynauds, Hypothyroid, Chiari Malformation, Hypopituitary,

Secondary Adrenal Insufficiency, Bilateral Thansverse Sinus Stenosis, ?

Thromophilia

>

> www.caringbridge.org/visit/melissahall

>