Re: What is the difference between PSC and PBC?

[Guest guest]

My mom has PBC and my daughter has PSC too much of a coincidence to me.Play online games for FREE at Games.com! All of your favorites, no registration required and great graphics – check it out!

[Guest guest]

My mom has PBC and my daughter has PSC too much of a coincidence to me.Play online games for FREE at Games.com! All of your favorites, no registration required and great graphics – check it out!

[Guest guest]

My mom has PBC and my daughter has PSC too much of a coincidence to me.Play online games for FREE at Games.com! All of your favorites, no registration required and great graphics – check it out!

[Guest guest]

Hi ;

PBC (primary biliary cirrhosis) is a disease that mostly affects the

small bile ducts. It is usually diagnosed by elevated liver function

tests (alanine aminotransferase, aspartate aminotransferase, alkaline

phosphatase and gamma-glutamyltranspeptidase) AND presence of

antimitochondrial antibodies (AMA). PBC mostly affects women, and only

rarely is associated with inflammatory bowel disease.

PSC (primary sclerosing cholangitis) can affect both the small and

large bile ducts, it is also associated with elevated liver function

tests (alanine aminotransferase, aspartate aminotransferase, alkaline

phosphatase and gamma-glutamyltranspeptidase), but is NOT associated

with antimitochondrial antibodies (AMA). PSC more often affects men

rather than women (2:1) and is commly associated with inflammatory

bowel disease.

PSC is usually diagnosed by ERCP or MRCP, and the visualization of the

biliary tree .... there is a characteristic beaded appearance of the

medium and/or large bile ducts. There is a version of PSC, however,

that affects only the small ducts, it is usually not possible to

diagnose small-duct PSC or PBC with ERCP or MRCP.

If you are not AMA-positive, it is unlikely that you have PBC,

(although a small percentage (<5% I think) of PBC patients are AMA-

negative).

If you have inflammatory bowel disease (ulcerative colitis or Crohn's

disease) it is more likely that you have PSC.

Have you had an ERCP or MRCP, and what were the results?

Have you been diagnosed with ulcerative colitis or Crohn's disease?

Have the doctors checked you for antimitochondrial antibodies (AMA)?

Answers to these questions will help distinguish whether you may have

PBC, classic PSC, or small-duct PSC.

Best regards,

Dave

(father of (23); PSC 07/03; UC 08/03)

>

> As more I read about PBC symptoms as more I think that I've got PBC

and

> not PSC.

> Can someone explain me what is the difference between those diseases

> and what is PBC : how is it diagnosd?

> Thanks

>

[Guest guest]

Hi ;

PBC (primary biliary cirrhosis) is a disease that mostly affects the

small bile ducts. It is usually diagnosed by elevated liver function

tests (alanine aminotransferase, aspartate aminotransferase, alkaline

phosphatase and gamma-glutamyltranspeptidase) AND presence of

antimitochondrial antibodies (AMA). PBC mostly affects women, and only

rarely is associated with inflammatory bowel disease.

PSC (primary sclerosing cholangitis) can affect both the small and

large bile ducts, it is also associated with elevated liver function

tests (alanine aminotransferase, aspartate aminotransferase, alkaline

phosphatase and gamma-glutamyltranspeptidase), but is NOT associated

with antimitochondrial antibodies (AMA). PSC more often affects men

rather than women (2:1) and is commly associated with inflammatory

bowel disease.

PSC is usually diagnosed by ERCP or MRCP, and the visualization of the

biliary tree .... there is a characteristic beaded appearance of the

medium and/or large bile ducts. There is a version of PSC, however,

that affects only the small ducts, it is usually not possible to

diagnose small-duct PSC or PBC with ERCP or MRCP.

If you are not AMA-positive, it is unlikely that you have PBC,

(although a small percentage (<5% I think) of PBC patients are AMA-

negative).

If you have inflammatory bowel disease (ulcerative colitis or Crohn's

disease) it is more likely that you have PSC.

Have you had an ERCP or MRCP, and what were the results?

Have you been diagnosed with ulcerative colitis or Crohn's disease?

Have the doctors checked you for antimitochondrial antibodies (AMA)?

Answers to these questions will help distinguish whether you may have

PBC, classic PSC, or small-duct PSC.

Best regards,

Dave

(father of (23); PSC 07/03; UC 08/03)

>

> As more I read about PBC symptoms as more I think that I've got PBC

and

> not PSC.

> Can someone explain me what is the difference between those diseases

> and what is PBC : how is it diagnosd?

> Thanks

>

[Guest guest]

Hi ;

PBC (primary biliary cirrhosis) is a disease that mostly affects the

small bile ducts. It is usually diagnosed by elevated liver function

tests (alanine aminotransferase, aspartate aminotransferase, alkaline

phosphatase and gamma-glutamyltranspeptidase) AND presence of

antimitochondrial antibodies (AMA). PBC mostly affects women, and only

rarely is associated with inflammatory bowel disease.

PSC (primary sclerosing cholangitis) can affect both the small and

large bile ducts, it is also associated with elevated liver function

tests (alanine aminotransferase, aspartate aminotransferase, alkaline

phosphatase and gamma-glutamyltranspeptidase), but is NOT associated

with antimitochondrial antibodies (AMA). PSC more often affects men

rather than women (2:1) and is commly associated with inflammatory

bowel disease.

PSC is usually diagnosed by ERCP or MRCP, and the visualization of the

biliary tree .... there is a characteristic beaded appearance of the

medium and/or large bile ducts. There is a version of PSC, however,

that affects only the small ducts, it is usually not possible to

diagnose small-duct PSC or PBC with ERCP or MRCP.

If you are not AMA-positive, it is unlikely that you have PBC,

(although a small percentage (<5% I think) of PBC patients are AMA-

negative).

If you have inflammatory bowel disease (ulcerative colitis or Crohn's

disease) it is more likely that you have PSC.

Have you had an ERCP or MRCP, and what were the results?

Have you been diagnosed with ulcerative colitis or Crohn's disease?

Have the doctors checked you for antimitochondrial antibodies (AMA)?

Answers to these questions will help distinguish whether you may have

PBC, classic PSC, or small-duct PSC.

Best regards,

Dave

(father of (23); PSC 07/03; UC 08/03)

>

> As more I read about PBC symptoms as more I think that I've got PBC

and

> not PSC.

> Can someone explain me what is the difference between those diseases

> and what is PBC : how is it diagnosd?

> Thanks

>

[Guest guest]

I did not have an AMA test, I'll ask my doctor to do it.

My MRCP was not specific, it showed a scantness of bile ducks.. (I am

not sure I translated it correctly) and an expansion of liver veins

and IVC.

And my ALT and AST were getting higher and higher with time.. now my

ALP also started to elevate until I increased the URSO dose.

So the only difference between PBC and PSC is the fact that PBC

cannot be visually diagnosed, but the AMA is positive?

(I have ANA positive +1 to +2 out of +4)

IS PBC also cureless like PSC?

> >

> > As more I read about PBC symptoms as more I think that I've got

PBC

> and

> > not PSC.

> > Can someone explain me what is the difference between those

diseases

> > and what is PBC : how is it diagnosd?

> > Thanks

> >

>

[Guest guest]

PBS is also cureless, but if it is caught

early enough, Ursolit gets you into almost indefinate remission.

Regards,

Chaim

P.S. Did you get my e-mail from Tuesday? I

wrote about PBC in it.

From: [mailto: ] On Behalf Of mishapog20

Sent: Thursday, October 23, 2008

10:58

To:

Subject: Re: What is

the difference between PSC and PBC?

I did not have an AMA test, I'll ask my doctor to do

it.

My MRCP was not specific, it showed a scantness of bile ducks.. (I am

not sure I translated it correctly) and an expansion of liver veins

and IVC.

And my ALT and AST were getting higher and higher with time.. now my

ALP also started to elevate until I increased the URSO dose.

So the only difference between PBC and PSC is the fact that PBC

cannot be visually diagnosed, but the AMA is positive?

(I have ANA positive +1 to +2 out of +4)

IS PBC also cureless like PSC?

> >

> > As more I read about PBC symptoms as more I think that I've got

PBC

> and

> > not PSC.

> > Can someone explain me what is the difference between those

diseases

> > and what is PBC : how is it diagnosd?

> > Thanks

> >

>

[Guest guest]

PBC affects the bile ducts inside the liver (intrahepatic) PSC affects

the bile ducts inside and outside of the liver. The AMA is checked with

a blood test and I would be rather surprized if this was not checked

when your liver function bloodwork was done.

PSC '07 Listed Baylor All Saints/Baylor