Re: fatigue and body aches-

[Guest guest]

Dear Lori;

I did read your message (# 109320) on the immune treatments, and your revelation

that you and your son have both been diagnosed with ataxia

telangiectasia; I guess that begins to explain the curious Ig deficiencies that

you have been reporting, and that I have been trying to interpret [with not much

luck I might add!] (see e.g. message # 104449).

Staples ER, McDermott EM, Reiman A, Byrd PJ, Ritchie S, AM, Davies EG

(2008) Immunodeficiency in ataxia telangiectasia is correlated strongly with the

presence of two null mutations in the ataxia telangiectasia mutated gene. Clin.

Exp. Immunol. 153: 214-220.

PMID: 18505428.

http://www.ncbi.nlm.nih.gov/pubmed/18505428

Without trying to write a thesis on whether I think IVIG (intravenous

immunoglobin) treatments can be effective in PSC, I'd like to say simply that

it's really not been tested yet, but might be worth a try? To justify this very

bland statement, I'd like to encourage you to do some searches on PubMed

(http://www.ncbi.nlm.nih.gov/pubmed/) with the following terms, and look at the

results obtained:

Search term: IVIG and immunodeficiency

1218 results

Search term: IVIG and autoimmune

1411 results

Search term: IVIG and inflammatory bowel disease

30 results

Search term: IVIG and Crohn's disease

19 results

Search term: IVIG and ulcerative colitis

12 results

Search term: IVIG and sclerosing cholangitis

3 results (all related to sclerosing cholangitis associated with hyper-IgM

syndrome)

Search term: IVIG and primary sclerosing cholangitis

2 results (both represented in the previous search results)

When it comes to primary sclerosing cholangitis, the results recovered actually

catch the terms " primary " immunodeficiency, and " sclerosing cholangitis " in the

abstracts, so strictly there are 0 results on IVIG and PSC!

Best regards,

Dave

(father of (23); PSC 07/03; UC 08/03)

>

> hi -

> I am curious if you think IVIG treatments can be effective in treating PSC ?