T4 crosses the blood brain barrier

[Guest guest]

In a message dated 3/16/2005 2:39:35 PM Eastern Standard Time,

lmcgaha@... writes:

> The figures quoted for Armour are that

> it's around 80% T4, 20% T3, plus small amounts of T1 and T2.

right. and calcitonin.

cindi

[Guest guest]

In a message dated 3/16/2005 2:39:35 PM Eastern Standard Time,

lmcgaha@... writes:

> The figures quoted for Armour are that

> it's around 80% T4, 20% T3, plus small amounts of T1 and T2.

right. and calcitonin.

cindi

[Guest guest]

In a message dated 3/16/2005 2:39:35 PM Eastern Standard Time,

lmcgaha@... writes:

> The figures quoted for Armour are that

> it's around 80% T4, 20% T3, plus small amounts of T1 and T2.

right. and calcitonin.

cindi

[Guest guest]

In a message dated 3/16/2005 3:29:48 PM Eastern Standard Time,

saltillo@... writes:

> I have read in many publications the

> the brain is not very good at converting T4 to T3 and that the brain

> has a high need for T3 and that is why the thyroid makes about 10 to

> 20% T3. Both thyroid hormones can cross the blood brain barrier

i agree with you. and this is consistent with what i've read - but more

importantly, what i have experienced.

There are days when I feel slight depression return to me...i glance at the

clock...and see i'm a bit late in taking my afternoon dose. within an hour of

taking that dose (2 grains), the depression has lifted. that's the T3 in the

Armour that i took doing that. pure good T3 straight to my hungry brain.

cindi

[Guest guest]

In a message dated 3/16/2005 3:29:48 PM Eastern Standard Time,

saltillo@... writes:

> I have read in many publications the

> the brain is not very good at converting T4 to T3 and that the brain

> has a high need for T3 and that is why the thyroid makes about 10 to

> 20% T3. Both thyroid hormones can cross the blood brain barrier

i agree with you. and this is consistent with what i've read - but more

importantly, what i have experienced.

There are days when I feel slight depression return to me...i glance at the

clock...and see i'm a bit late in taking my afternoon dose. within an hour of

taking that dose (2 grains), the depression has lifted. that's the T3 in the

Armour that i took doing that. pure good T3 straight to my hungry brain.

cindi

[Guest guest]

In a message dated 3/16/2005 3:29:48 PM Eastern Standard Time,

saltillo@... writes:

> I have read in many publications the

> the brain is not very good at converting T4 to T3 and that the brain

> has a high need for T3 and that is why the thyroid makes about 10 to

> 20% T3. Both thyroid hormones can cross the blood brain barrier

i agree with you. and this is consistent with what i've read - but more

importantly, what i have experienced.

There are days when I feel slight depression return to me...i glance at the

clock...and see i'm a bit late in taking my afternoon dose. within an hour of

taking that dose (2 grains), the depression has lifted. that's the T3 in the

Armour that i took doing that. pure good T3 straight to my hungry brain.

cindi

[Guest guest]

> T4 is actually what is

> used in the brain - T3 cannot cross the blood brain barrier, but T4

> can, and it gets converted there into T3.

I can't give you a reference now, but I remember reading that T3 is needed

for the brain, because the brain doesn't convert T4 well. Supposedly that's

one of the reasons that hypothyroids given T3 & T4 instead of just T4 have a

better mental and emotional state, as reported in the NEJM research piece

several years ago. The eye is another place that needs T3 directly.

Would you happen to remember where you got your information from?

Lynn

[Guest guest]

>

> > T4 is actually what is

> > used in the brain - T3 cannot cross the blood brain barrier, but

T4

> > can, and it gets converted there into T3.

>

> I can't give you a reference now, but I remember reading that T3

is needed

> for the brain, because the brain doesn't convert T4 well.

Supposedly that's

> one of the reasons that hypothyroids given T3 & T4 instead of just

T4 have a

> better mental and emotional state, as reported in the NEJM

research piece

> several years ago. The eye is another place that needs T3

directly.

>

> Would you happen to remember where you got your information from?

>

> Lynn

Lynn, I did post this ... go back a few posts.

Nat

[Guest guest]

>

> > T4 is actually what is

> > used in the brain - T3 cannot cross the blood brain barrier, but

T4

> > can, and it gets converted there into T3.

>

> I can't give you a reference now, but I remember reading that T3

is needed

> for the brain, because the brain doesn't convert T4 well.

Supposedly that's

> one of the reasons that hypothyroids given T3 & T4 instead of just

T4 have a

> better mental and emotional state, as reported in the NEJM

research piece

> several years ago. The eye is another place that needs T3

directly.

>

> Would you happen to remember where you got your information from?

>

> Lynn

Lynn, I did post this ... go back a few posts.

Nat

[Guest guest]

>

> > T4 is actually what is

> > used in the brain - T3 cannot cross the blood brain barrier, but

T4

> > can, and it gets converted there into T3.

>

> I can't give you a reference now, but I remember reading that T3

is needed

> for the brain, because the brain doesn't convert T4 well.

Supposedly that's

> one of the reasons that hypothyroids given T3 & T4 instead of just

T4 have a

> better mental and emotional state, as reported in the NEJM

research piece

> several years ago. The eye is another place that needs T3

directly.

>

> Would you happen to remember where you got your information from?

>

> Lynn

Lynn, I did post this ... go back a few posts.

Nat

[Guest guest]

I jumped the gun in replying to the brain T4-T3 conversion issue, because I

hadn't finished reading all of the posts, and now I see that a number were

already made in reply to this issue. I appreciate all the great research

articles that were posted.

As for Randy's post that the thyroid only makes T-4, and all the other Ts

come from conversion in the liver, I think he is dead wrong. I've read

numerous places that the human thyroid produces close to 80-90% T4,

something like 10% T3 (the exact figures vary depending on the source), and

very small quantities of T1 and T2. The figures quoted for Armour are that

it's around 80% T4, 20% T3, plus small amounts of T1 and T2. So that's

proof that the pig thyroid makes T4, T3, T2, and T1, and I think humans are

the same, the percentages are just different. I agree the liver will also

deiodinase the T4, but that's in addition to actual T3 production.

Lynn

> I posted earlier and I really think that the T-4 is converted to the other

elements in the liver. Please correct me if I am wrong.

>

> Randy

>

> Lynn McGaha lmcgaha@...> wrote:

>

> > T4 is actually what is

> > used in the brain - T3 cannot cross the blood brain barrier, but T4

> > can, and it gets converted there into T3.

>

> I can't give you a reference now, but I remember reading that T3 is needed

> for the brain, because the brain doesn't convert T4 well. Supposedly

that's

> one of the reasons that hypothyroids given T3 & T4 instead of just T4 have

a

> better mental and emotional state, as reported in the NEJM research piece

> several years ago. The eye is another place that needs T3 directly.

>

> Would you happen to remember where you got your information from?

>

> Lynn

[Guest guest]

I jumped the gun in replying to the brain T4-T3 conversion issue, because I

hadn't finished reading all of the posts, and now I see that a number were

already made in reply to this issue. I appreciate all the great research

articles that were posted.

As for Randy's post that the thyroid only makes T-4, and all the other Ts

come from conversion in the liver, I think he is dead wrong. I've read

numerous places that the human thyroid produces close to 80-90% T4,

something like 10% T3 (the exact figures vary depending on the source), and

very small quantities of T1 and T2. The figures quoted for Armour are that

it's around 80% T4, 20% T3, plus small amounts of T1 and T2. So that's

proof that the pig thyroid makes T4, T3, T2, and T1, and I think humans are

the same, the percentages are just different. I agree the liver will also

deiodinase the T4, but that's in addition to actual T3 production.

Lynn

> I posted earlier and I really think that the T-4 is converted to the other

elements in the liver. Please correct me if I am wrong.

>

> Randy

>

> Lynn McGaha lmcgaha@...> wrote:

>

> > T4 is actually what is

> > used in the brain - T3 cannot cross the blood brain barrier, but T4

> > can, and it gets converted there into T3.

>

> I can't give you a reference now, but I remember reading that T3 is needed

> for the brain, because the brain doesn't convert T4 well. Supposedly

that's

> one of the reasons that hypothyroids given T3 & T4 instead of just T4 have

a

> better mental and emotional state, as reported in the NEJM research piece

> several years ago. The eye is another place that needs T3 directly.

>

> Would you happen to remember where you got your information from?

>

> Lynn

[Guest guest]

I jumped the gun in replying to the brain T4-T3 conversion issue, because I

hadn't finished reading all of the posts, and now I see that a number were

already made in reply to this issue. I appreciate all the great research

articles that were posted.

As for Randy's post that the thyroid only makes T-4, and all the other Ts

come from conversion in the liver, I think he is dead wrong. I've read

numerous places that the human thyroid produces close to 80-90% T4,

something like 10% T3 (the exact figures vary depending on the source), and

very small quantities of T1 and T2. The figures quoted for Armour are that

it's around 80% T4, 20% T3, plus small amounts of T1 and T2. So that's

proof that the pig thyroid makes T4, T3, T2, and T1, and I think humans are

the same, the percentages are just different. I agree the liver will also

deiodinase the T4, but that's in addition to actual T3 production.

Lynn

> I posted earlier and I really think that the T-4 is converted to the other

elements in the liver. Please correct me if I am wrong.

>

> Randy

>

> Lynn McGaha lmcgaha@...> wrote:

>

> > T4 is actually what is

> > used in the brain - T3 cannot cross the blood brain barrier, but T4

> > can, and it gets converted there into T3.

>

> I can't give you a reference now, but I remember reading that T3 is needed

> for the brain, because the brain doesn't convert T4 well. Supposedly

that's

> one of the reasons that hypothyroids given T3 & T4 instead of just T4 have

a

> better mental and emotional state, as reported in the NEJM research piece

> several years ago. The eye is another place that needs T3 directly.

>

> Would you happen to remember where you got your information from?

>

> Lynn

[Guest guest]

> > T4 is actually what is

> > used in the brain - T3 cannot cross the blood brain barrier, but

T4

________________

I really dissagree with this. I have read in many publications the

the brain is not very good at converting T4 to T3 and that the brain

has a high need for T3 and that is why the thyroid makes about 10 to

20% T3. Both thyroid hormones can cross the blood brain barrier. The

brain lacks one enzyme pathway for converting T4 to T3. There seems

to be a big contradiction between one recent bit of research and

years of clinical experience showing that the brain needs T3 either

produced by the thyroid or in replacement medication. At the bottom

are sources to support my contention. There are lots and lots more

than I have here.

This paper says T3 readily crosses the blood brain barrier.

http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?

cmd=Retrieve&db=PubMed&list_uids=6822088&dopt=Abstract

I think the material you are talking about may come from this site

below, but I am not sure this person is right since I have seen much

more information saying the opposit of this idea. In fact there is a

lot of information on how T3 therapy aids depressive conditions an

other brain problems. I think that not all is understood about T3

and the brain.

http://www.ncf-net.org/forum/99gold.htm

However, if one wishes to increase thyroid hormone levels in the

brain, administering T3 or Cytomel is not a good idea because the

mitochondria, the energy producing organelles in the neurons of the

brain, are unable to use T3. Instead, they take up T4 and deiodinate

the T4 to T3

____________________________

Here is a paper on T3 therapy and improving depression:

http://www.biopsychiatry.com/thyroidt3t4.htm

_______________________________

Here is a paper that says T4 therapy seems to worsen depression:

http://www.drmirkin.com/morehealth/G171.htm

This site says that T3 is very improtant for the brain:

http://www.webheights.net/depression/arem/ts.htm

Mounting evidence suggest that T3, the most potent form of thyroid

hormone, is a bona fide brain chemical. It is found in the junction

of nerve (synapse) cells that allow these cells to communicate with

one another. This thyroid hormone also regulates the levels and

actions of serotonin, noradrenaline, and GABA (gamma-aminobutyric

acid), now accepted as the main chemical transmitters implicated in

both depression and some anxiety disorders. Maintaining normal

serotonin and noradrenaline levels in the brain depends to a great

extent on whether the correct amount of T3 is available. Extensive

animal and human research has led scientists to conclude that

serotonin levels in the brain decrease if T3 is not delivered in the

right amount. Also, a deficit of T3 in the brain is likely to result

in noradrenaline's working inefficiently as a chemical transmitter,

and noradrenaline deficiency or inefficiency is, in some people, the

chemical reason for depression.

____________________

Another study found that giving T3 with T4 increased cognitive

function and memory in patients.

________________________

http://thyroid.about.com/gi/dynamic/offsite.htm?

site=http://www.johndommissemd.com/report1a.html

In patients with hypothyroidism, partial substitution of

triiodothyronine [T3] for thyroxine [T4] may improve mood and

neuropsychological function; this finding suggests a specific effect

of the triiodothyronine normally secreted by the thyroid gland. "

__________________

" Use of T3 Thyroid Hormone to Treat Depression " by Gabe Mirkin, M.D.

http://www.drmirkin.com/morehealth/G171.htm

" …some people become depressed when they take just T4 and their

depression can be cured when they take both thyroid hormones, T3 and

T4. "

__________________

Is Your Hypothyroidism UNDERtreated? " 08/14/99 by Shomon,

author of About.com Guide to Thyroid Disease and Living Well With

Hypothyroidism

http://thyroid.about.com/library/weekly/aa081499.htm

the addition of T3 helped relieve depression, brain fog, fatigue and

other symptoms. "

____________________

A collection of patients' experiences with the use of T3

http://x66.deja.com/getdoc.xp?AN=719588180 (longer version)

Even with just the T4 I was still depressed, anxiety attacks, weight

gain, foggy head, tired, etc. The T3 immediately cleared the foggy

head and the other symptoms went away soon after. "

_____________________

http://www.docguide.com/dg.nsf/PrintPrint/9C0B1C01C743FC1385256715005

05E9A

" From this work we concluded that the small amount of T3 secreted by

the normal thyroid gland may be important to the brain even if it is

not very important to other tissues, " Prange said.

Tish

[Guest guest]

> > T4 is actually what is

> > used in the brain - T3 cannot cross the blood brain barrier, but

T4

________________

I really dissagree with this. I have read in many publications the

the brain is not very good at converting T4 to T3 and that the brain

has a high need for T3 and that is why the thyroid makes about 10 to

20% T3. Both thyroid hormones can cross the blood brain barrier. The

brain lacks one enzyme pathway for converting T4 to T3. There seems

to be a big contradiction between one recent bit of research and

years of clinical experience showing that the brain needs T3 either

produced by the thyroid or in replacement medication. At the bottom

are sources to support my contention. There are lots and lots more

than I have here.

This paper says T3 readily crosses the blood brain barrier.

http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?

cmd=Retrieve&db=PubMed&list_uids=6822088&dopt=Abstract

I think the material you are talking about may come from this site

below, but I am not sure this person is right since I have seen much

more information saying the opposit of this idea. In fact there is a

lot of information on how T3 therapy aids depressive conditions an

other brain problems. I think that not all is understood about T3

and the brain.

http://www.ncf-net.org/forum/99gold.htm

However, if one wishes to increase thyroid hormone levels in the

brain, administering T3 or Cytomel is not a good idea because the

mitochondria, the energy producing organelles in the neurons of the

brain, are unable to use T3. Instead, they take up T4 and deiodinate

the T4 to T3

____________________________

Here is a paper on T3 therapy and improving depression:

http://www.biopsychiatry.com/thyroidt3t4.htm

_______________________________

Here is a paper that says T4 therapy seems to worsen depression:

http://www.drmirkin.com/morehealth/G171.htm

This site says that T3 is very improtant for the brain:

http://www.webheights.net/depression/arem/ts.htm

Mounting evidence suggest that T3, the most potent form of thyroid

hormone, is a bona fide brain chemical. It is found in the junction

of nerve (synapse) cells that allow these cells to communicate with

one another. This thyroid hormone also regulates the levels and

actions of serotonin, noradrenaline, and GABA (gamma-aminobutyric

acid), now accepted as the main chemical transmitters implicated in

both depression and some anxiety disorders. Maintaining normal

serotonin and noradrenaline levels in the brain depends to a great

extent on whether the correct amount of T3 is available. Extensive

animal and human research has led scientists to conclude that

serotonin levels in the brain decrease if T3 is not delivered in the

right amount. Also, a deficit of T3 in the brain is likely to result

in noradrenaline's working inefficiently as a chemical transmitter,

and noradrenaline deficiency or inefficiency is, in some people, the

chemical reason for depression.

____________________

Another study found that giving T3 with T4 increased cognitive

function and memory in patients.

________________________

http://thyroid.about.com/gi/dynamic/offsite.htm?

site=http://www.johndommissemd.com/report1a.html

In patients with hypothyroidism, partial substitution of

triiodothyronine [T3] for thyroxine [T4] may improve mood and

neuropsychological function; this finding suggests a specific effect

of the triiodothyronine normally secreted by the thyroid gland. "

__________________

" Use of T3 Thyroid Hormone to Treat Depression " by Gabe Mirkin, M.D.

http://www.drmirkin.com/morehealth/G171.htm

" …some people become depressed when they take just T4 and their

depression can be cured when they take both thyroid hormones, T3 and

T4. "

__________________

Is Your Hypothyroidism UNDERtreated? " 08/14/99 by Shomon,

author of About.com Guide to Thyroid Disease and Living Well With

Hypothyroidism

http://thyroid.about.com/library/weekly/aa081499.htm

the addition of T3 helped relieve depression, brain fog, fatigue and

other symptoms. "

____________________

A collection of patients' experiences with the use of T3

http://x66.deja.com/getdoc.xp?AN=719588180 (longer version)

Even with just the T4 I was still depressed, anxiety attacks, weight

gain, foggy head, tired, etc. The T3 immediately cleared the foggy

head and the other symptoms went away soon after. "

_____________________

http://www.docguide.com/dg.nsf/PrintPrint/9C0B1C01C743FC1385256715005

05E9A

" From this work we concluded that the small amount of T3 secreted by

the normal thyroid gland may be important to the brain even if it is

not very important to other tissues, " Prange said.

Tish

[Guest guest]

> > T4 is actually what is

> > used in the brain - T3 cannot cross the blood brain barrier, but

T4

________________

I really dissagree with this. I have read in many publications the

the brain is not very good at converting T4 to T3 and that the brain

has a high need for T3 and that is why the thyroid makes about 10 to

20% T3. Both thyroid hormones can cross the blood brain barrier. The

brain lacks one enzyme pathway for converting T4 to T3. There seems

to be a big contradiction between one recent bit of research and

years of clinical experience showing that the brain needs T3 either

produced by the thyroid or in replacement medication. At the bottom

are sources to support my contention. There are lots and lots more

than I have here.

This paper says T3 readily crosses the blood brain barrier.

http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?

cmd=Retrieve&db=PubMed&list_uids=6822088&dopt=Abstract

I think the material you are talking about may come from this site

below, but I am not sure this person is right since I have seen much

more information saying the opposit of this idea. In fact there is a

lot of information on how T3 therapy aids depressive conditions an

other brain problems. I think that not all is understood about T3

and the brain.

http://www.ncf-net.org/forum/99gold.htm

However, if one wishes to increase thyroid hormone levels in the

brain, administering T3 or Cytomel is not a good idea because the

mitochondria, the energy producing organelles in the neurons of the

brain, are unable to use T3. Instead, they take up T4 and deiodinate

the T4 to T3

____________________________

Here is a paper on T3 therapy and improving depression:

http://www.biopsychiatry.com/thyroidt3t4.htm

_______________________________

Here is a paper that says T4 therapy seems to worsen depression:

http://www.drmirkin.com/morehealth/G171.htm

This site says that T3 is very improtant for the brain:

http://www.webheights.net/depression/arem/ts.htm

Mounting evidence suggest that T3, the most potent form of thyroid

hormone, is a bona fide brain chemical. It is found in the junction

of nerve (synapse) cells that allow these cells to communicate with

one another. This thyroid hormone also regulates the levels and

actions of serotonin, noradrenaline, and GABA (gamma-aminobutyric

acid), now accepted as the main chemical transmitters implicated in

both depression and some anxiety disorders. Maintaining normal

serotonin and noradrenaline levels in the brain depends to a great

extent on whether the correct amount of T3 is available. Extensive

animal and human research has led scientists to conclude that

serotonin levels in the brain decrease if T3 is not delivered in the

right amount. Also, a deficit of T3 in the brain is likely to result

in noradrenaline's working inefficiently as a chemical transmitter,

and noradrenaline deficiency or inefficiency is, in some people, the

chemical reason for depression.

____________________

Another study found that giving T3 with T4 increased cognitive

function and memory in patients.

________________________

http://thyroid.about.com/gi/dynamic/offsite.htm?

site=http://www.johndommissemd.com/report1a.html

In patients with hypothyroidism, partial substitution of

triiodothyronine [T3] for thyroxine [T4] may improve mood and

neuropsychological function; this finding suggests a specific effect

of the triiodothyronine normally secreted by the thyroid gland. "

__________________

" Use of T3 Thyroid Hormone to Treat Depression " by Gabe Mirkin, M.D.

http://www.drmirkin.com/morehealth/G171.htm

" …some people become depressed when they take just T4 and their

depression can be cured when they take both thyroid hormones, T3 and

T4. "

__________________

Is Your Hypothyroidism UNDERtreated? " 08/14/99 by Shomon,

author of About.com Guide to Thyroid Disease and Living Well With

Hypothyroidism

http://thyroid.about.com/library/weekly/aa081499.htm

the addition of T3 helped relieve depression, brain fog, fatigue and

other symptoms. "

____________________

A collection of patients' experiences with the use of T3

http://x66.deja.com/getdoc.xp?AN=719588180 (longer version)

Even with just the T4 I was still depressed, anxiety attacks, weight

gain, foggy head, tired, etc. The T3 immediately cleared the foggy

head and the other symptoms went away soon after. "

_____________________

http://www.docguide.com/dg.nsf/PrintPrint/9C0B1C01C743FC1385256715005

05E9A

" From this work we concluded that the small amount of T3 secreted by

the normal thyroid gland may be important to the brain even if it is

not very important to other tissues, " Prange said.

Tish

[Guest guest]

As I said earlier, Tish - you can find 'proof' to back up either

side of the arguement.

>

> > > T4 is actually what is

> > > used in the brain - T3 cannot cross the blood brain barrier,

but

> T4

> ________________

> I really dissagree with this. I have read in many publications the

> the brain is not very good at converting T4 to T3 and that the

brain

> has a high need for T3 and that is why the thyroid makes about 10

to

> 20% T3. Both thyroid hormones can cross the blood brain barrier.

The

> brain lacks one enzyme pathway for converting T4 to T3. There

seems

> to be a big contradiction between one recent bit of research and

> years of clinical experience showing that the brain needs T3

either

> produced by the thyroid or in replacement medication. At the

bottom

> are sources to support my contention. There are lots and lots more

> than I have here.

>

> This paper says T3 readily crosses the blood brain barrier.

> http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?

> cmd=Retrieve&db=PubMed&list_uids=6822088&dopt=Abstract

>

> I think the material you are talking about may come from this site

> below, but I am not sure this person is right since I have seen

much

> more information saying the opposit of this idea. In fact there is

a

> lot of information on how T3 therapy aids depressive conditions an

> other brain problems. I think that not all is understood about T3

> and the brain.

>

> http://www.ncf-net.org/forum/99gold.htm

> However, if one wishes to increase thyroid hormone levels in the

> brain, administering T3 or Cytomel is not a good idea because the

> mitochondria, the energy producing organelles in the neurons of

the

> brain, are unable to use T3. Instead, they take up T4 and

deiodinate

> the T4 to T3

> ____________________________

> Here is a paper on T3 therapy and improving depression:

> http://www.biopsychiatry.com/thyroidt3t4.htm

> _______________________________

> Here is a paper that says T4 therapy seems to worsen depression:

> http://www.drmirkin.com/morehealth/G171.htm

>

> This site says that T3 is very improtant for the brain:

> http://www.webheights.net/depression/arem/ts.htm

> Mounting evidence suggest that T3, the most potent form of thyroid

> hormone, is a bona fide brain chemical. It is found in the

junction

> of nerve (synapse) cells that allow these cells to communicate

with

> one another. This thyroid hormone also regulates the levels and

> actions of serotonin, noradrenaline, and GABA (gamma-aminobutyric

> acid), now accepted as the main chemical transmitters implicated

in

> both depression and some anxiety disorders. Maintaining normal

> serotonin and noradrenaline levels in the brain depends to a great

> extent on whether the correct amount of T3 is available. Extensive

> animal and human research has led scientists to conclude that

> serotonin levels in the brain decrease if T3 is not delivered in

the

> right amount. Also, a deficit of T3 in the brain is likely to

result

> in noradrenaline's working inefficiently as a chemical

transmitter,

> and noradrenaline deficiency or inefficiency is, in some people,

the

> chemical reason for depression.

> ____________________

> Another study found that giving T3 with T4 increased cognitive

> function and memory in patients.

> ________________________

> http://thyroid.about.com/gi/dynamic/offsite.htm?

> site=http://www.johndommissemd.com/report1a.html

>

> In patients with hypothyroidism, partial substitution of

> triiodothyronine [T3] for thyroxine [T4] may improve mood and

> neuropsychological function; this finding suggests a specific

effect

> of the triiodothyronine normally secreted by the thyroid gland. "

> __________________

> " Use of T3 Thyroid Hormone to Treat Depression " by Gabe Mirkin,

M.D.

> http://www.drmirkin.com/morehealth/G171.htm

>

> " …some people become depressed when they take just T4 and their

> depression can be cured when they take both thyroid hormones, T3

and

> T4. "

> __________________

> Is Your Hypothyroidism UNDERtreated? " 08/14/99 by Shomon,

> author of About.com Guide to Thyroid Disease and Living Well With

> Hypothyroidism

> http://thyroid.about.com/library/weekly/aa081499.htm

>

> the addition of T3 helped relieve depression, brain fog, fatigue

and

> other symptoms. "

> ____________________

> A collection of patients' experiences with the use of T3

> http://x66.deja.com/getdoc.xp?AN=719588180 (longer version)

>

> Even with just the T4 I was still depressed, anxiety attacks,

weight

> gain, foggy head, tired, etc. The T3 immediately cleared the foggy

> head and the other symptoms went away soon after. "

> _____________________

>

http://www.docguide.com/dg.nsf/PrintPrint/9C0B1C01C743FC1385256715005

> 05E9A

>

> " From this work we concluded that the small amount of T3 secreted

by

> the normal thyroid gland may be important to the brain even if it

is

> not very important to other tissues, " Prange said.

>

> Tish

[Guest guest]

As I said earlier, Tish - you can find 'proof' to back up either

side of the arguement.

>

> > > T4 is actually what is

> > > used in the brain - T3 cannot cross the blood brain barrier,

but

> T4

> ________________

> I really dissagree with this. I have read in many publications the

> the brain is not very good at converting T4 to T3 and that the

brain

> has a high need for T3 and that is why the thyroid makes about 10

to

> 20% T3. Both thyroid hormones can cross the blood brain barrier.

The

> brain lacks one enzyme pathway for converting T4 to T3. There

seems

> to be a big contradiction between one recent bit of research and

> years of clinical experience showing that the brain needs T3

either

> produced by the thyroid or in replacement medication. At the

bottom

> are sources to support my contention. There are lots and lots more

> than I have here.

>

> This paper says T3 readily crosses the blood brain barrier.

> http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?

> cmd=Retrieve&db=PubMed&list_uids=6822088&dopt=Abstract

>

> I think the material you are talking about may come from this site

> below, but I am not sure this person is right since I have seen

much

> more information saying the opposit of this idea. In fact there is

a

> lot of information on how T3 therapy aids depressive conditions an

> other brain problems. I think that not all is understood about T3

> and the brain.

>

> http://www.ncf-net.org/forum/99gold.htm

> However, if one wishes to increase thyroid hormone levels in the

> brain, administering T3 or Cytomel is not a good idea because the

> mitochondria, the energy producing organelles in the neurons of

the

> brain, are unable to use T3. Instead, they take up T4 and

deiodinate

> the T4 to T3

> ____________________________

> Here is a paper on T3 therapy and improving depression:

> http://www.biopsychiatry.com/thyroidt3t4.htm

> _______________________________

> Here is a paper that says T4 therapy seems to worsen depression:

> http://www.drmirkin.com/morehealth/G171.htm

>

> This site says that T3 is very improtant for the brain:

> http://www.webheights.net/depression/arem/ts.htm

> Mounting evidence suggest that T3, the most potent form of thyroid

> hormone, is a bona fide brain chemical. It is found in the

junction

> of nerve (synapse) cells that allow these cells to communicate

with

> one another. This thyroid hormone also regulates the levels and

> actions of serotonin, noradrenaline, and GABA (gamma-aminobutyric

> acid), now accepted as the main chemical transmitters implicated

in

> both depression and some anxiety disorders. Maintaining normal

> serotonin and noradrenaline levels in the brain depends to a great

> extent on whether the correct amount of T3 is available. Extensive

> animal and human research has led scientists to conclude that

> serotonin levels in the brain decrease if T3 is not delivered in

the

> right amount. Also, a deficit of T3 in the brain is likely to

result

> in noradrenaline's working inefficiently as a chemical

transmitter,

> and noradrenaline deficiency or inefficiency is, in some people,

the

> chemical reason for depression.

> ____________________

> Another study found that giving T3 with T4 increased cognitive

> function and memory in patients.

> ________________________

> http://thyroid.about.com/gi/dynamic/offsite.htm?

> site=http://www.johndommissemd.com/report1a.html

>

> In patients with hypothyroidism, partial substitution of

> triiodothyronine [T3] for thyroxine [T4] may improve mood and

> neuropsychological function; this finding suggests a specific

effect

> of the triiodothyronine normally secreted by the thyroid gland. "

> __________________

> " Use of T3 Thyroid Hormone to Treat Depression " by Gabe Mirkin,

M.D.

> http://www.drmirkin.com/morehealth/G171.htm

>

> " …some people become depressed when they take just T4 and their

> depression can be cured when they take both thyroid hormones, T3

and

> T4. "

> __________________

> Is Your Hypothyroidism UNDERtreated? " 08/14/99 by Shomon,

> author of About.com Guide to Thyroid Disease and Living Well With

> Hypothyroidism

> http://thyroid.about.com/library/weekly/aa081499.htm

>

> the addition of T3 helped relieve depression, brain fog, fatigue

and

> other symptoms. "

> ____________________

> A collection of patients' experiences with the use of T3

> http://x66.deja.com/getdoc.xp?AN=719588180 (longer version)

>

> Even with just the T4 I was still depressed, anxiety attacks,

weight

> gain, foggy head, tired, etc. The T3 immediately cleared the foggy

> head and the other symptoms went away soon after. "

> _____________________

>

http://www.docguide.com/dg.nsf/PrintPrint/9C0B1C01C743FC1385256715005

> 05E9A

>

> " From this work we concluded that the small amount of T3 secreted

by

> the normal thyroid gland may be important to the brain even if it

is

> not very important to other tissues, " Prange said.

>

> Tish

[Guest guest]

As I said earlier, Tish - you can find 'proof' to back up either

side of the arguement.

>

> > > T4 is actually what is

> > > used in the brain - T3 cannot cross the blood brain barrier,

but

> T4

> ________________

> I really dissagree with this. I have read in many publications the

> the brain is not very good at converting T4 to T3 and that the

brain

> has a high need for T3 and that is why the thyroid makes about 10

to

> 20% T3. Both thyroid hormones can cross the blood brain barrier.

The

> brain lacks one enzyme pathway for converting T4 to T3. There

seems

> to be a big contradiction between one recent bit of research and

> years of clinical experience showing that the brain needs T3

either

> produced by the thyroid or in replacement medication. At the

bottom

> are sources to support my contention. There are lots and lots more

> than I have here.

>

> This paper says T3 readily crosses the blood brain barrier.

> http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?

> cmd=Retrieve&db=PubMed&list_uids=6822088&dopt=Abstract

>

> I think the material you are talking about may come from this site

> below, but I am not sure this person is right since I have seen

much

> more information saying the opposit of this idea. In fact there is

a

> lot of information on how T3 therapy aids depressive conditions an

> other brain problems. I think that not all is understood about T3

> and the brain.

>

> http://www.ncf-net.org/forum/99gold.htm

> However, if one wishes to increase thyroid hormone levels in the

> brain, administering T3 or Cytomel is not a good idea because the

> mitochondria, the energy producing organelles in the neurons of

the

> brain, are unable to use T3. Instead, they take up T4 and

deiodinate

> the T4 to T3

> ____________________________

> Here is a paper on T3 therapy and improving depression:

> http://www.biopsychiatry.com/thyroidt3t4.htm

> _______________________________

> Here is a paper that says T4 therapy seems to worsen depression:

> http://www.drmirkin.com/morehealth/G171.htm

>

> This site says that T3 is very improtant for the brain:

> http://www.webheights.net/depression/arem/ts.htm

> Mounting evidence suggest that T3, the most potent form of thyroid

> hormone, is a bona fide brain chemical. It is found in the

junction

> of nerve (synapse) cells that allow these cells to communicate

with

> one another. This thyroid hormone also regulates the levels and

> actions of serotonin, noradrenaline, and GABA (gamma-aminobutyric

> acid), now accepted as the main chemical transmitters implicated

in

> both depression and some anxiety disorders. Maintaining normal

> serotonin and noradrenaline levels in the brain depends to a great

> extent on whether the correct amount of T3 is available. Extensive

> animal and human research has led scientists to conclude that

> serotonin levels in the brain decrease if T3 is not delivered in

the

> right amount. Also, a deficit of T3 in the brain is likely to

result

> in noradrenaline's working inefficiently as a chemical

transmitter,

> and noradrenaline deficiency or inefficiency is, in some people,

the

> chemical reason for depression.

> ____________________

> Another study found that giving T3 with T4 increased cognitive

> function and memory in patients.

> ________________________

> http://thyroid.about.com/gi/dynamic/offsite.htm?

> site=http://www.johndommissemd.com/report1a.html

>

> In patients with hypothyroidism, partial substitution of

> triiodothyronine [T3] for thyroxine [T4] may improve mood and

> neuropsychological function; this finding suggests a specific

effect

> of the triiodothyronine normally secreted by the thyroid gland. "

> __________________

> " Use of T3 Thyroid Hormone to Treat Depression " by Gabe Mirkin,

M.D.

> http://www.drmirkin.com/morehealth/G171.htm

>

> " …some people become depressed when they take just T4 and their

> depression can be cured when they take both thyroid hormones, T3

and

> T4. "

> __________________

> Is Your Hypothyroidism UNDERtreated? " 08/14/99 by Shomon,

> author of About.com Guide to Thyroid Disease and Living Well With

> Hypothyroidism

> http://thyroid.about.com/library/weekly/aa081499.htm

>

> the addition of T3 helped relieve depression, brain fog, fatigue

and

> other symptoms. "

> ____________________

> A collection of patients' experiences with the use of T3

> http://x66.deja.com/getdoc.xp?AN=719588180 (longer version)

>

> Even with just the T4 I was still depressed, anxiety attacks,

weight

> gain, foggy head, tired, etc. The T3 immediately cleared the foggy

> head and the other symptoms went away soon after. "

> _____________________

>

http://www.docguide.com/dg.nsf/PrintPrint/9C0B1C01C743FC1385256715005

> 05E9A

>

> " From this work we concluded that the small amount of T3 secreted

by

> the normal thyroid gland may be important to the brain even if it

is

> not very important to other tissues, " Prange said.

>

> Tish