Alterations in hepatic glucose and energy metabolism as a result of calorie and carbohydrate restriction.

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Carbohydrate restriction is a common weight-loss

approach that modifies hepatic metabolism by increasing gluconeogenesis

(GNG) and ketosis. Because little is known about the

effect of carbohydrate restriction on the origin of gluconeogenic

precursors (GNG from glycerol [GNG(glycerol)] and GNG

from lactate/amino acids [GNG(phosphoenolpyruvate

{PEP})]) or its consequence to hepatic energy homeostasis, we studied these

parameters in a group of overweight/obese subjects undergoing weight-loss via

dietary restriction. http://www.ncbi.nlm.nih.gov/pubmed/18925642

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Son Ken (34) UC 91 PSC 99, LTX 6/21 & 6/30 2007

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