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Tauroursodeoxycholic acid exerts anticholestatic effects by a cooperative cPKC alpha-/PKA-dependent mechanism in rat liver.

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in Health, Medicine and Natural Healing 08

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OBJECTIVE: Ursodeoxycholic

acid (UDCA) exerts anticholestatic effects in part by

protein kinase C (PKC)-dependent mechanisms. Its taurine conjugate, TUDCA, is

a cPKC alpha agonist. We

tested whether protein kinase A (PKA) might

contribute to the anticholestatic action of TUDCA via

cooperative cPKC alpha-/PKA-dependent mechanisms in taurolithocholic acid (TLCA)-induced cholestasis.

http://www.ncbi.nlm.nih.gov/pubmed/18583398

Barb in Texas - Together in the Fight - Whatever it

Takes!

Son Ken (34) UC 91 PSC 99, LTX 6/21 & 6/30 2007

@ Baylor/Dallas

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