Re: Ursodiol and vitamin D help keep bile sterile

[Guest guest]

Hi ,

So this means, although not fully proven, it would be a good idea to

take vitamin D when I take Urso?

Cheers,

[Guest guest]

Dear , who seems to be the expert out there or anyone else, My son Tyler Ostos with PSC and UC has recently had trouble seeing his letters correct. He says he sees them upside down or on top of each other. We saw an optomologist who says he has 20/20 vision and can find nothing wrong with his sight. He does border on ADHD (Hyper trait) and is very bright in addition to all his other medical issues. Ty is on Urso, Remicade infusions and Azacol, Singulair. Any clues? his psychologist says Dyslexia does not normally pop up out of no where. He never had trouble reading before. But, Tyler says it is very frustrating and he is a bit frighteneed. Help????

Stevie Ostos (Mother to Tyler age 11 and McKenna age 6)

[Guest guest]

Dear , who seems to be the expert out there or anyone else, My son Tyler Ostos with PSC and UC has recently had trouble seeing his letters correct. He says he sees them upside down or on top of each other. We saw an optomologist who says he has 20/20 vision and can find nothing wrong with his sight. He does border on ADHD (Hyper trait) and is very bright in addition to all his other medical issues. Ty is on Urso, Remicade infusions and Azacol, Singulair. Any clues? his psychologist says Dyslexia does not normally pop up out of no where. He never had trouble reading before. But, Tyler says it is very frustrating and he is a bit frighteneed. Help????

Stevie Ostos (Mother to Tyler age 11 and McKenna age 6)

[Guest guest]

Dear , who seems to be the expert out there or anyone else, My son Tyler Ostos with PSC and UC has recently had trouble seeing his letters correct. He says he sees them upside down or on top of each other. We saw an optomologist who says he has 20/20 vision and can find nothing wrong with his sight. He does border on ADHD (Hyper trait) and is very bright in addition to all his other medical issues. Ty is on Urso, Remicade infusions and Azacol, Singulair. Any clues? his psychologist says Dyslexia does not normally pop up out of no where. He never had trouble reading before. But, Tyler says it is very frustrating and he is a bit frighteneed. Help????

Stevie Ostos (Mother to Tyler age 11 and McKenna age 6)

[Guest guest]

Dear Stevie;

I am by no means an expert (but I did stay at a Holiday Inn last

night!) ... sorry, I couldn't resist that attempt at a joke based on

a T.V. commercial in the U.S.

Seriosly, our son suffered from dyslexia throughout school. He had

one-on-one assistance from a reading specialist (a wonderful lady!)

who helped him considerably. He also had " accommodations " (extra time

for exams). In hindsight we think he may have had an omega-3

deficiency. Our reasoning is as follows:

1. He hardly ever ate fish (the main dietary source of omega-3's).

2. When he went on fish oil supplements, his acne (skin inflammation)

improved dramatically, and he now reports markedly improved reading

comprehension [he's now in medical school and has to do a great of

reading!].

3. Docosahexaenoic acid (DHA) is a major component of fish oil, and

is the main omega-3 fatty acid in the brain. There's growing evidence

that DHA has beneficial effects in dyslexia, see for example:

J Med Food. 2007 Dec;10(4):662-6.

A 5-month open study with long-chain polyunsaturated fatty acids in

dyslexia.

Lindmark L, Clough P

Falsterbo, Sweden. lars.lindmark@...

This open pilot study investigated effects of a docosahexaenoic acid

(DHA)-rich supplement on learning ability in a group of 20 dyslexic

children in Sweden. Children formally diagnosed as dyslexic took

eight capsules per day of a long-chain polyunsaturated fatty acid (LC-

PUFA) supplement containing high-DHA fish oil and evening primrose

oil. Subjective assessments by the children and their parents were

completed at baseline and 6, 12, and 20 weeks after supplementation.

Quantitative evaluation by word-chain test was completed before and

after 4 months of supplementation to measure word decoding (speed of

reading) and letter decoding (motoric-perceptual speed). Subjective

parent and child assessments showed increasing numbers of positive

responders over time in reading speed, general schoolwork, and

overall perceived benefit. Significant improvements were observed in

reading speed and motor-perceptual velocity. Thirteen of 17 children

had a significant improvement on the word-chain test (P < .04).

Reading speed improved by 60% from 1.76 +/- 0.29 before the study to

2.82 +/- 0.36 after supplementation (P < .01 by Wilcoxon sign test).

Motoric-perceptual velocity improved by 23% from a stanine value of

3.76 +/- 0.42 to 4.65 +/- 0.66 after supplementation (P < .05 by

Wilcoxon sign test). Thus LC-PUFA supplementation for 5 months

provides positive and clear beneficial effect on variables usually

impaired by dyslexia. PMID: 18158838.

A recent PSC Partners Seeking a Cure award for best research

presented at the 2008 AASLD meeting went to a group that is studying

the beneficial effects of DHA in primary sclerosing cholangitis! It

improves liver function tests (alkaline phosphatase).

My reading indicates that DHA could be serving as an activator of the

retinoid X receptor (RXR), which is a master controller of liver bile

acid metabolism and transport. I can provide references on this topic

if you are interested.

I think that DHA-deficiency is a common thread that links autoimmune

(autoinflammatory) disease, PSC, reading disorders and depression.

If Tyler is not already taking fish oils, please consider talking to

Tyler's doctor(s) about this supplement.

Best regards,

Dave

(father of (23); PSC 07/03; UC 08/03)

[Guest guest]

,

After taking the fish oil (omega 3) does your son still have Dyslexia?

Lori A.

"Aggressively Pursuing Solutions To Your Real Estate Needs!"

First Weber Group

Cell:

1507 E. Sunset Drive

Waukesha, WI 53189

LoriUSA@...

www.Lori.FirstWeber.com

To: Sent: Wednesday, December 17, 2008 1:26:04 PMSubject: Re: Ursodiol and vitamin D help keep bile sterile

Dear Stevie;I am by no means an expert (but I did stay at a Holiday Inn last night!) ... sorry, I couldn't resist that attempt at a joke based on a T.V. commercial in the U.S. Seriosly, our son suffered from dyslexia throughout school. He had one-on-one assistance from a reading specialist (a wonderful lady!) who helped him considerably. He also had "accommodations" (extra time for exams). In hindsight we think he may have had an omega-3 deficiency. Our reasoning is as follows:1. He hardly ever ate fish (the main dietary source of omega-3's).2. When he went on fish oil supplements, his acne (skin inflammation) improved dramatically, and he now reports markedly improved reading comprehension [he's now in medical school and has to do a great of reading!].3. Docosahexaenoic acid (DHA) is a major component of fish oil, and is the main omega-3 fatty acid in the brain. There's growing

evidence that DHA has beneficial effects in dyslexia, see for example:J Med Food. 2007 Dec;10(4):662- 6. A 5-month open study with long-chain polyunsaturated fatty acids in dyslexia.Lindmark L, Clough PFalsterbo, Sweden. lars.lindmark@ telia.comThis open pilot study investigated effects of a docosahexaenoic acid (DHA)-rich supplement on learning ability in a group of 20 dyslexic children in Sweden. Children formally diagnosed as dyslexic took eight capsules per day of a long-chain polyunsaturated fatty acid (LC-PUFA) supplement containing high-DHA fish oil and evening primrose oil. Subjective assessments by the children and their parents were completed at baseline and 6, 12, and 20 weeks after supplementation. Quantitative evaluation by word-chain test was

completed before and after 4 months of supplementation to measure word decoding (speed of reading) and letter decoding (motoric-perceptual speed). Subjective parent and child assessments showed increasing numbers of positive responders over time in reading speed, general schoolwork, and overall perceived benefit. Significant improvements were observed in reading speed and motor-perceptual velocity. Thirteen of 17 children had a significant improvement on the word-chain test (P < .04). Reading speed improved by 60% from 1.76 +/- 0.29 before the study to 2.82 +/- 0.36 after supplementation (P < .01 by Wilcoxon sign test). Motoric-perceptual velocity improved by 23% from a stanine value of 3.76 +/- 0.42 to 4.65 +/- 0.66 after supplementation (P < .05 by Wilcoxon sign test). Thus LC-PUFA supplementation for 5 months provides positive and clear beneficial effect on variables usually impaired by

dyslexia. PMID: 18158838.A recent PSC Partners Seeking a Cure award for best research presented at the 2008 AASLD meeting went to a group that is studying the beneficial effects of DHA in primary sclerosing cholangitis! It improves liver function tests (alkaline phosphatase) .My reading indicates that DHA could be serving as an activator of the retinoid X receptor (RXR), which is a master controller of liver bile acid metabolism and transport. I can provide references on this topic if you are interested.I think that DHA-deficiency is a common thread that links autoimmune (autoinflammatory) disease, PSC, reading disorders and depression. If Tyler is not already taking fish oils, please consider talking to Tyler's doctor(s) about this supplement.Best regards,Dave (father of (23); PSC 07/03; UC 08/03)

[Guest guest]

Hi ;

Yes, I think that would be a good idea. Many patients with IBD and PSC

develop vitamin deficiencies (including vitamins A, D, E and K).

Vitamin D is very important for bone health, protection against colon

cancer, protection against autoimmune diseases, and would now seem to

have the added benefit of keeping the bile sterile (at least according

to the article I posted yesterday):

Nutr. Rev. 66 (10 Suppl 2): S182-S194 (2008)

Vitamin D: a D-lightful health perspective.

Holick MF

The Department of Medicine, Section of Endocrinology, Nutrition, and

Diabetes, Vitamin D, Skin and Bone Research Laboratory, Boston

University Medical Center, Boston, Massachusetts, USA. mfholick@...

Sunlight provides most humans with their vitamin D requirement.

Adequate vitamin D(3) by synthesis in the skin or from dietary and

supplemental sources is essential for bone health throughout life.

Vitamin D deficiency is defined as a 25(OH)D concentration <20 ng/mL

(50 nmol/L); vitamin D sufficiency as a 25(OH)D >30 ng/mL (75 nmol/L),

and insufficiency as 21-29 ng/mL. Vitamin D deficiency and

insufficiency has been linked to a wide variety of chronic diseases

including common cancers, autoimmune, cardiovascular, and infectious

diseases. Healthcare professionals need to be aware of the vitamin D

deficiency pandemic. Guidelines for sensible sun exposure and

supplemental vitamin D of 800-1000 IU/day are needed. PMID: 18844847.

Vitamin A is also very important for your immune system:

Ann. N. Y. Acad. Sci. 1143: 170-87 (2008)

Retinoic acid in the immune system.

Pino-Lagos K, Benson MJ, Noelle RJ

Department of Microbiology and Immunology, Dartmouth College, Dartmouth

Medical School, Lebanon, NH 03756, USA.

On occasion, emerging scientific fields intersect and great discoveries

result. In the last decade, the discovery of regulatory T cells (T

(reg)) in immunity has revolutionized our understanding of how the

immune system is controlled. Intersecting the rapidly emerging field of

T(reg) function, has been the discovery that retinoic acid (RA)

controls both the homing and differentiation of T(reg). Instantly, the

wealth and breadth of knowledge of the molecular basis for RA action,

its receptors, and how it controls cellular differentiation can and

will be exploited to understand its profound effects on T(reg).

Historically, vitamin A deprivation and repletion and RA agonists have

been shown to profoundly affect immunity. Now these findings can be

interpreted in light of the revelations that RA controls leukocyte

homing and T(reg) function. PMID: 19076350.

But you have to be very cautious in not " over-dosing " with vitamin A.

At high levels is can be toxic to the liver:

J. Am. Diet. Assoc. 108: 1536-1537 (2008)

Potential liver damage associated with over-the-counter vitamin

supplements.

Sheth A, Khurana R, Khurana V

Department of Gastroenterology, and R. Khurana is clinical fellow,

Department of Rheumatology, Louisiana State University Health Sciences

Center, Shreveport, LA, USA.

The growing popularity and availability of over-the-counter (OTC)

health products, including vitamins, raises serious concern about

vitamin toxicity. We report a case of cirrhosis in a patient with

habitual daily ingestion of an OTC dietary supplement that contained

13,000 microg vitamin A and was associated with marked clinical

improvement after discontinuation. This case highlights the potential

for liver damage that may be associated with long-term intake of OTC

vitamin supplements, and indicates the need for medical supervision of

such products. PMID: 18755329.

So you should not self-medicate with vitamin A; please see you doctor

if you suspect vitamin A deficiency so that he/she can work with you to

carefully correct the deficiency.

Best regards,

Dave

(father of (23); PSC 07/03; UC 08/03)

>

> Hi ,

>

> So this means, although not fully proven, it would be a good idea to

> take vitamin D when I take Urso?

>

> Cheers,

>

>

>

[Guest guest]

Hi Lori;

He says that his reading ability and concentration have increased

dramatically.

Best regards,

Dave R.

> After taking the fish oil (omega 3) does your son still have Dyslexia?

[Guest guest]

Hi Lori;

He says that his reading ability and concentration have increased

dramatically.

Best regards,

Dave R.

> After taking the fish oil (omega 3) does your son still have Dyslexia?

[Guest guest]

To: Sent: Wednesday, December 17, 2008 12:46:32 PMSubject: Re: Re: Ursodiol and vitamin D help keep bile sterile

,

After taking the fish oil (omega 3) does your son still have Dyslexia?

Lori A.

"Aggressively Pursuing Solutions To Your Real Estate Needs!"

First Weber Group

Cell:

1507 E. Sunset Drive

Waukesha, WI 53189

LoriUSA@ Yahoo.com

www.Lori.FirstWeber .com

From: <rhodesdavid1@ comcast.net>To: @ yahoogroups. comSent: Wednesday, December 17, 2008 1:26:04 PMSubject: Re: Ursodiol and vitamin D help keep bile sterile

Dear Stevie;I am by no means an expert (but I did stay at a Holiday Inn last night!) ... sorry, I couldn't resist that attempt at a joke based on a T.V. commercial in the U.S. Seriosly, our son suffered from dyslexia throughout school. He had one-on-one assistance from a reading specialist (a wonderful lady!) who helped him considerably. He also had "accommodations" (extra time for exams). In hindsight we think he may have had an omega-3 deficiency. Our reasoning is as follows:1. He hardly ever ate fish (the main dietary source of omega-3's).2. When he went on fish oil supplements, his acne (skin inflammation) improved dramatically, and he now reports markedly improved reading comprehension [he's now in medical school and has to do a great of reading!].3. Docosahexaenoic acid (DHA) is a major component of fish oil, and is the main omega-3 fatty acid in the brain. There's growing

evidence that DHA has beneficial effects in dyslexia, see for example:J Med Food. 2007 Dec;10(4):662- 6. A 5-month open study with long-chain polyunsaturated fatty acids in dyslexia.Lindmark L, Clough PFalsterbo, Sweden. lars.lindmark@ telia.comThis open pilot study investigated effects of a docosahexaenoic acid (DHA)-rich supplement on learning ability in a group of 20 dyslexic children in Sweden. Children formally diagnosed as dyslexic took eight capsules per day of a long-chain polyunsaturated fatty acid (LC-PUFA) supplement containing high-DHA fish oil and evening primrose oil. Subjective assessments by the children and their parents were completed at baseline and 6, 12, and 20 weeks after supplementation. Quantitative evaluation by word-chain test was

completed before and after 4 months of supplementation to measure word decoding (speed of reading) and letter decoding (motoric-perceptual speed). Subjective parent and child assessments showed increasing numbers of positive responders over time in reading speed, general schoolwork, and overall perceived benefit. Significant improvements were observed in reading speed and motor-perceptual velocity. Thirteen of 17 children had a significant improvement on the word-chain test (P < .04). Reading speed improved by 60% from 1.76 +/- 0.29 before the study to 2.82 +/- 0.36 after supplementation (P < .01 by Wilcoxon sign test). Motoric-perceptual velocity improved by 23% from a stanine value of 3.76 +/- 0.42 to 4.65 +/- 0.66 after supplementation (P < .05 by Wilcoxon sign test). Thus LC-PUFA supplementation for 5 months provides positive and clear beneficial effect on variables usually impaired by

dyslexia. PMID: 18158838.A recent PSC Partners Seeking a Cure award for best research presented at the 2008 AASLD meeting went to a group that is studying the beneficial effects of DHA in primary sclerosing cholangitis! It improves liver function tests (alkaline phosphatase) .My reading indicates that DHA could be serving as an activator of the retinoid X receptor (RXR), which is a master controller of liver bile acid metabolism and transport. I can provide references on this topic if you are interested.I think that DHA-deficiency is a common thread that links autoimmune (autoinflammatory) disease, PSC, reading disorders and depression. If Tyler is not already taking fish oils, please consider talking to Tyler's doctor(s) about this supplement.Best regards,Dave (father of (23); PSC 07/03; UC

08/03)

[Guest guest]

To: Sent: Wednesday, December 17, 2008 12:46:32 PMSubject: Re: Re: Ursodiol and vitamin D help keep bile sterile

,

After taking the fish oil (omega 3) does your son still have Dyslexia?

Lori A.

"Aggressively Pursuing Solutions To Your Real Estate Needs!"

First Weber Group

Cell:

1507 E. Sunset Drive

Waukesha, WI 53189

LoriUSA@ Yahoo.com

www.Lori.FirstWeber .com

From: <rhodesdavid1@ comcast.net>To: @ yahoogroups. comSent: Wednesday, December 17, 2008 1:26:04 PMSubject: Re: Ursodiol and vitamin D help keep bile sterile

Dear Stevie;I am by no means an expert (but I did stay at a Holiday Inn last night!) ... sorry, I couldn't resist that attempt at a joke based on a T.V. commercial in the U.S. Seriosly, our son suffered from dyslexia throughout school. He had one-on-one assistance from a reading specialist (a wonderful lady!) who helped him considerably. He also had "accommodations" (extra time for exams). In hindsight we think he may have had an omega-3 deficiency. Our reasoning is as follows:1. He hardly ever ate fish (the main dietary source of omega-3's).2. When he went on fish oil supplements, his acne (skin inflammation) improved dramatically, and he now reports markedly improved reading comprehension [he's now in medical school and has to do a great of reading!].3. Docosahexaenoic acid (DHA) is a major component of fish oil, and is the main omega-3 fatty acid in the brain. There's growing

evidence that DHA has beneficial effects in dyslexia, see for example:J Med Food. 2007 Dec;10(4):662- 6. A 5-month open study with long-chain polyunsaturated fatty acids in dyslexia.Lindmark L, Clough PFalsterbo, Sweden. lars.lindmark@ telia.comThis open pilot study investigated effects of a docosahexaenoic acid (DHA)-rich supplement on learning ability in a group of 20 dyslexic children in Sweden. Children formally diagnosed as dyslexic took eight capsules per day of a long-chain polyunsaturated fatty acid (LC-PUFA) supplement containing high-DHA fish oil and evening primrose oil. Subjective assessments by the children and their parents were completed at baseline and 6, 12, and 20 weeks after supplementation. Quantitative evaluation by word-chain test was

completed before and after 4 months of supplementation to measure word decoding (speed of reading) and letter decoding (motoric-perceptual speed). Subjective parent and child assessments showed increasing numbers of positive responders over time in reading speed, general schoolwork, and overall perceived benefit. Significant improvements were observed in reading speed and motor-perceptual velocity. Thirteen of 17 children had a significant improvement on the word-chain test (P < .04). Reading speed improved by 60% from 1.76 +/- 0.29 before the study to 2.82 +/- 0.36 after supplementation (P < .01 by Wilcoxon sign test). Motoric-perceptual velocity improved by 23% from a stanine value of 3.76 +/- 0.42 to 4.65 +/- 0.66 after supplementation (P < .05 by Wilcoxon sign test). Thus LC-PUFA supplementation for 5 months provides positive and clear beneficial effect on variables usually impaired by

dyslexia. PMID: 18158838.A recent PSC Partners Seeking a Cure award for best research presented at the 2008 AASLD meeting went to a group that is studying the beneficial effects of DHA in primary sclerosing cholangitis! It improves liver function tests (alkaline phosphatase) .My reading indicates that DHA could be serving as an activator of the retinoid X receptor (RXR), which is a master controller of liver bile acid metabolism and transport. I can provide references on this topic if you are interested.I think that DHA-deficiency is a common thread that links autoimmune (autoinflammatory) disease, PSC, reading disorders and depression. If Tyler is not already taking fish oils, please consider talking to Tyler's doctor(s) about this supplement.Best regards,Dave (father of (23); PSC 07/03; UC

08/03)

[Guest guest]

To: Sent: Wednesday, December 17, 2008 12:46:32 PMSubject: Re: Re: Ursodiol and vitamin D help keep bile sterile

,

After taking the fish oil (omega 3) does your son still have Dyslexia?

Lori A.

"Aggressively Pursuing Solutions To Your Real Estate Needs!"

First Weber Group

Cell:

1507 E. Sunset Drive

Waukesha, WI 53189

LoriUSA@ Yahoo.com

www.Lori.FirstWeber .com

From: <rhodesdavid1@ comcast.net>To: @ yahoogroups. comSent: Wednesday, December 17, 2008 1:26:04 PMSubject: Re: Ursodiol and vitamin D help keep bile sterile

Dear Stevie;I am by no means an expert (but I did stay at a Holiday Inn last night!) ... sorry, I couldn't resist that attempt at a joke based on a T.V. commercial in the U.S. Seriosly, our son suffered from dyslexia throughout school. He had one-on-one assistance from a reading specialist (a wonderful lady!) who helped him considerably. He also had "accommodations" (extra time for exams). In hindsight we think he may have had an omega-3 deficiency. Our reasoning is as follows:1. He hardly ever ate fish (the main dietary source of omega-3's).2. When he went on fish oil supplements, his acne (skin inflammation) improved dramatically, and he now reports markedly improved reading comprehension [he's now in medical school and has to do a great of reading!].3. Docosahexaenoic acid (DHA) is a major component of fish oil, and is the main omega-3 fatty acid in the brain. There's growing

evidence that DHA has beneficial effects in dyslexia, see for example:J Med Food. 2007 Dec;10(4):662- 6. A 5-month open study with long-chain polyunsaturated fatty acids in dyslexia.Lindmark L, Clough PFalsterbo, Sweden. lars.lindmark@ telia.comThis open pilot study investigated effects of a docosahexaenoic acid (DHA)-rich supplement on learning ability in a group of 20 dyslexic children in Sweden. Children formally diagnosed as dyslexic took eight capsules per day of a long-chain polyunsaturated fatty acid (LC-PUFA) supplement containing high-DHA fish oil and evening primrose oil. Subjective assessments by the children and their parents were completed at baseline and 6, 12, and 20 weeks after supplementation. Quantitative evaluation by word-chain test was

completed before and after 4 months of supplementation to measure word decoding (speed of reading) and letter decoding (motoric-perceptual speed). Subjective parent and child assessments showed increasing numbers of positive responders over time in reading speed, general schoolwork, and overall perceived benefit. Significant improvements were observed in reading speed and motor-perceptual velocity. Thirteen of 17 children had a significant improvement on the word-chain test (P < .04). Reading speed improved by 60% from 1.76 +/- 0.29 before the study to 2.82 +/- 0.36 after supplementation (P < .01 by Wilcoxon sign test). Motoric-perceptual velocity improved by 23% from a stanine value of 3.76 +/- 0.42 to 4.65 +/- 0.66 after supplementation (P < .05 by Wilcoxon sign test). Thus LC-PUFA supplementation for 5 months provides positive and clear beneficial effect on variables usually impaired by

dyslexia. PMID: 18158838.A recent PSC Partners Seeking a Cure award for best research presented at the 2008 AASLD meeting went to a group that is studying the beneficial effects of DHA in primary sclerosing cholangitis! It improves liver function tests (alkaline phosphatase) .My reading indicates that DHA could be serving as an activator of the retinoid X receptor (RXR), which is a master controller of liver bile acid metabolism and transport. I can provide references on this topic if you are interested.I think that DHA-deficiency is a common thread that links autoimmune (autoinflammatory) disease, PSC, reading disorders and depression. If Tyler is not already taking fish oils, please consider talking to Tyler's doctor(s) about this supplement.Best regards,Dave (father of (23); PSC 07/03; UC

08/03)