Melatonin Could Be A Potential Anti-Fibrotic Drug

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In

this study, hepatic fibrosis in rats was successfully induced

by subcutaneous injection of sterile CCl4 twice weekly for a total of 12 wk. At

the beginning of injection of CCl4, melatonin (2.5, 5, 10 mg/kg body weight) was intraperitoneally administered

to the rats daily for 12 wk. Hepatic fibrotic changes

were evaluated biochemically by measuring tissue hydroxyproline levels and histopathogical

examination. The serum activities of alanine aminotransferase (ALT), aspartate

aminotransferase (AST) were used

to evaluate the hepatic injury. Hepatic oxidative stress markers were evaluated

by changes in the amount of lipid peroxides, measured

as malondialdehyde (MDA) and glutathione peroxidase (GPx) in liver

homogenates. Serum hyaluronic acid (HA), laminin (LN), and procollagen 3 N-terminal peptide (P3NP) were determined as serum markers

of hepatic fibrogenesis.

Their

results suggested that……..

http://www.redorbit.com/news/health/1662457/melatonin_could_be_a_potential_antifibrotic_drug/index.html

Barb in Texas - Together in the Fight - Whatever it

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Son Ken (34) UC 91 PSC 99, LTX 6/21 &

6/30 2007 @ Baylor/Dallas