Liver transplant immunosupression controlled clinical trial.

[Guest guest]

Dear all,

I'm at the top of the liver waiting list in Kings College Hospital in

London, UK. I've just been signed up for a clinical trial:

" Novartis Clinical Trial Protocol CRAD001H2304: A 24 month,

multi-center, open-label, randomized, controlled study to evaluate the

efficacy and safety of concentration-controlled everolimus to eliminate

or to reduce tacrolimus compared to tacrolimus in de novo liver

transplant recipients "

More information: http://www.vanderbilthealth.com/transplant/18929

Has anyone else been treated with Everolimus, or is anyone else on this

trial? I believe it is limited to patients between 18-65 with no

significant renal impairment, and who are undergoing first whole-liver

heart-beating-donor liver transplants. It certainly sounds interesting -

Everolimus has been found to be significantly less nephrotoxic than

Tacrolimus in immunosupression following transplant.

Anyone else's experiences would be welcome!

Thanks

PSC DX 09-2005, TX-Listed 10-2008