Guest guest Posted December 15, 2008 Report Share Posted December 15, 2008 Hi Gwynn; One hypothesis is that polyarteritis nodosa is caused by the hepatitis B virus: _______________________________ Ther Umsch. 2008 May;65(5):247-51.Links Polyarteritis Nodosa, a vanishing vasculitis since its main cause has been identified. Frey FJ Klinik und Poliklinik für Nephrologie und Hypertonie, Inselspital, Bern. felix.frey@... The polyarteritis nodosa is a vasculitis for which the main cause had been identified as hepatitis B, a chronic infectious disease inducing an overshooting immune reaction. Thanks to this discovery, the treatment of polyarteritis nodosa has changed from a symptomatic immunosuppressive therapy to a treatment strategy focusing on the disease inducing infectious agent. Vaccination against hepatitis B- virus has been instrumental in the reduction of the prevalence of polyarteritis nodosa. In case of the rare entity of polyarteritis nodosa without hepatitis B, only a symptomatic immunosuppressive therapy can be prescribed. The history of polyarteritis nodosa clearly illustrates that future research in the field of so called autoimmune diseases should focus on the causes rather than on the immunologic effector mechanisms and/or the symptomatic immunosuppressive therapy. PMID: 18622927. _______________________________ But it is also interesting to me that it can be caused by hepatitis B vaccination!!! _______________________________ Eur J Intern Med. 2008 Dec;19(8):575-8 Systemic polyarteritis nodosa following hepatitis B vaccination. de Carvalho JF, Pereira RM, Shoenfeld Y Rheumatology Division, São o University School of Medicine, São o, Brazil. The authors report a patient who developed systemic polyarteritis nodosa two months after hepatitis B vaccination and review the literature concerning this vaccination and the development of autoimmune conditions, mainly vasculitis. A 14-year-old boy who had no relevant previous history and who was not taking any drugs presented with a livedo reticularis, fever, loss of weight, testicular pain, and paresthesias two months after receiving the third dose of a hepatitis B vaccination. Inflammatory parameters (ESR and CRP) were high. The patient met the ACR diagnostic criteria for polyarteritis nodosa. He received corticosteroids and immunosuppressants and showed improvement. After reviewing the 27 cases of vasculitis after hepatitis B vaccination reported in the current literature, the authors suggest that, in some cases, vaccination may be the triggering factor for vasculitis in individuals with a genetic predisposition. Physicians should be aware of this possible association. PMID: 19046721. _______________________________ Did you daughter have a hepatitis B vaccination prior to onset of polyarteritis? I have been interested in adverse effects of Hep B vaccination since it did not escape my attention that my son's PSC/UC developed after hepatitis B vaccination. Best regards, Dave (father of (23); PSC 07/03; UC 08/03) > > Has anyone in this group ever heard of or had polyarteritis. My > daughter is experiencing intense pain after she eats. Her Dr. now > thinks she may have this vascular disease???? > > Any info will be welcome. > > Gwynn (Mother of Cheryl 19 Vaculitis 2005, PSC/UC 2006 > Quote Link to comment Share on other sites More sharing options...
Guest guest Posted December 15, 2008 Report Share Posted December 15, 2008 Hi Gwynn; One hypothesis is that polyarteritis nodosa is caused by the hepatitis B virus: _______________________________ Ther Umsch. 2008 May;65(5):247-51.Links Polyarteritis Nodosa, a vanishing vasculitis since its main cause has been identified. Frey FJ Klinik und Poliklinik für Nephrologie und Hypertonie, Inselspital, Bern. felix.frey@... The polyarteritis nodosa is a vasculitis for which the main cause had been identified as hepatitis B, a chronic infectious disease inducing an overshooting immune reaction. Thanks to this discovery, the treatment of polyarteritis nodosa has changed from a symptomatic immunosuppressive therapy to a treatment strategy focusing on the disease inducing infectious agent. Vaccination against hepatitis B- virus has been instrumental in the reduction of the prevalence of polyarteritis nodosa. In case of the rare entity of polyarteritis nodosa without hepatitis B, only a symptomatic immunosuppressive therapy can be prescribed. The history of polyarteritis nodosa clearly illustrates that future research in the field of so called autoimmune diseases should focus on the causes rather than on the immunologic effector mechanisms and/or the symptomatic immunosuppressive therapy. PMID: 18622927. _______________________________ But it is also interesting to me that it can be caused by hepatitis B vaccination!!! _______________________________ Eur J Intern Med. 2008 Dec;19(8):575-8 Systemic polyarteritis nodosa following hepatitis B vaccination. de Carvalho JF, Pereira RM, Shoenfeld Y Rheumatology Division, São o University School of Medicine, São o, Brazil. The authors report a patient who developed systemic polyarteritis nodosa two months after hepatitis B vaccination and review the literature concerning this vaccination and the development of autoimmune conditions, mainly vasculitis. A 14-year-old boy who had no relevant previous history and who was not taking any drugs presented with a livedo reticularis, fever, loss of weight, testicular pain, and paresthesias two months after receiving the third dose of a hepatitis B vaccination. Inflammatory parameters (ESR and CRP) were high. The patient met the ACR diagnostic criteria for polyarteritis nodosa. He received corticosteroids and immunosuppressants and showed improvement. After reviewing the 27 cases of vasculitis after hepatitis B vaccination reported in the current literature, the authors suggest that, in some cases, vaccination may be the triggering factor for vasculitis in individuals with a genetic predisposition. Physicians should be aware of this possible association. PMID: 19046721. _______________________________ Did you daughter have a hepatitis B vaccination prior to onset of polyarteritis? I have been interested in adverse effects of Hep B vaccination since it did not escape my attention that my son's PSC/UC developed after hepatitis B vaccination. Best regards, Dave (father of (23); PSC 07/03; UC 08/03) > > Has anyone in this group ever heard of or had polyarteritis. My > daughter is experiencing intense pain after she eats. Her Dr. now > thinks she may have this vascular disease???? > > Any info will be welcome. > > Gwynn (Mother of Cheryl 19 Vaculitis 2005, PSC/UC 2006 > Quote Link to comment Share on other sites More sharing options...
Guest guest Posted December 15, 2008 Report Share Posted December 15, 2008 Hi Gwynn; One hypothesis is that polyarteritis nodosa is caused by the hepatitis B virus: _______________________________ Ther Umsch. 2008 May;65(5):247-51.Links Polyarteritis Nodosa, a vanishing vasculitis since its main cause has been identified. Frey FJ Klinik und Poliklinik für Nephrologie und Hypertonie, Inselspital, Bern. felix.frey@... The polyarteritis nodosa is a vasculitis for which the main cause had been identified as hepatitis B, a chronic infectious disease inducing an overshooting immune reaction. Thanks to this discovery, the treatment of polyarteritis nodosa has changed from a symptomatic immunosuppressive therapy to a treatment strategy focusing on the disease inducing infectious agent. Vaccination against hepatitis B- virus has been instrumental in the reduction of the prevalence of polyarteritis nodosa. In case of the rare entity of polyarteritis nodosa without hepatitis B, only a symptomatic immunosuppressive therapy can be prescribed. The history of polyarteritis nodosa clearly illustrates that future research in the field of so called autoimmune diseases should focus on the causes rather than on the immunologic effector mechanisms and/or the symptomatic immunosuppressive therapy. PMID: 18622927. _______________________________ But it is also interesting to me that it can be caused by hepatitis B vaccination!!! _______________________________ Eur J Intern Med. 2008 Dec;19(8):575-8 Systemic polyarteritis nodosa following hepatitis B vaccination. de Carvalho JF, Pereira RM, Shoenfeld Y Rheumatology Division, São o University School of Medicine, São o, Brazil. The authors report a patient who developed systemic polyarteritis nodosa two months after hepatitis B vaccination and review the literature concerning this vaccination and the development of autoimmune conditions, mainly vasculitis. A 14-year-old boy who had no relevant previous history and who was not taking any drugs presented with a livedo reticularis, fever, loss of weight, testicular pain, and paresthesias two months after receiving the third dose of a hepatitis B vaccination. Inflammatory parameters (ESR and CRP) were high. The patient met the ACR diagnostic criteria for polyarteritis nodosa. He received corticosteroids and immunosuppressants and showed improvement. After reviewing the 27 cases of vasculitis after hepatitis B vaccination reported in the current literature, the authors suggest that, in some cases, vaccination may be the triggering factor for vasculitis in individuals with a genetic predisposition. Physicians should be aware of this possible association. PMID: 19046721. _______________________________ Did you daughter have a hepatitis B vaccination prior to onset of polyarteritis? I have been interested in adverse effects of Hep B vaccination since it did not escape my attention that my son's PSC/UC developed after hepatitis B vaccination. Best regards, Dave (father of (23); PSC 07/03; UC 08/03) > > Has anyone in this group ever heard of or had polyarteritis. My > daughter is experiencing intense pain after she eats. Her Dr. now > thinks she may have this vascular disease???? > > Any info will be welcome. > > Gwynn (Mother of Cheryl 19 Vaculitis 2005, PSC/UC 2006 > Quote Link to comment Share on other sites More sharing options...
Guest guest Posted December 15, 2008 Report Share Posted December 15, 2008 Dear Gwynn; Does Cheryl's Dr. think that the polyarteritis may be causing her abdominal pain after eating (postprandial abdominal pain)?: Clin Gastroenterol Hepatol. 2008 Sep;6(9):960-6. Gastrointestinal involvement in polyarteritis nodosa. Ebert EC, Hagspiel KD, Nagar M, Schlesinger N. Department of Medicine, UMDNJ- Wood Medical School, New Brunswick, New Jersey 08901, USA. ebertec@... Polyarteritis nodosa (PAN) is a necrotizing, focal segmental vasculitis that affects predominantly medium-sized arteries in many different organ systems. It is associated with hepatitis B virus (HBV) in about 7% of cases, a decline from about 30% before the mandatory testing of blood products and the widespread vaccination programs. HBV PAN is an early postinfectious process. The hepatitis is silent in most cases, with mild transaminase level increases in 50% of patients. Gastrointestinal involvement occurs in 14% to 65% of patients with PAN. Postprandial abdominal pain from ischemia is the most common symptom. When transmural ischemia develops, there may be necrosis of the bowel wall with perforation, associated with a poor prognosis. Liver involvement occurs in 16% to 56% of patients, although clinical manifestations related to liver disease are quite rare. Acalculous gangrenous cholecystitis may develop owing to arteritis involving the wall of the gallbladder. Microaneurysms on arteriography or computed tomography angiography are characteristic of PAN, but are seen in other conditions. Tissue biopsy may confirm the diagnosis, although involvement is segmental. Corticosteroids are used for non-HBV PAN with cyclophosphamide added for severe disease. For PAN related to HBV, a 2-week course of corticosteroids is begun, with plasma exchanges and an antiviral agent. Corticosteroids and cyclophosphamide have improved patient outcome so that the 1-year survival rate is now about 85%. PMID: 18585977. Best regards, Dave R. > > Has anyone in this group ever heard of or had polyarteritis. My > daughter is experiencing intense pain after she eats. Her Dr. now > thinks she may have this vascular disease???? > > Any info will be welcome. > > Gwynn (Mother of Cheryl 19 Vaculitis 2005, PSC/UC 2006 > Quote Link to comment Share on other sites More sharing options...
Guest guest Posted December 15, 2008 Report Share Posted December 15, 2008 Thanks to all of you for your input regarding my daughter. She had the Hepatitis B shots when she was about 10 when we moved to Florida and they required that she have them to attend school there. She has since been tested for Hepatitis B but does not have it. , I am convinced my daughter contracted vasculitis, PSC and UC after she had a meningitis shot in New Zealand. We were living there at the time and Men B is quite a problem over there.....so not thinking to much about it she had the shot. 2 weeks later she developed a swollen ankle and we had no idea why, and thought she had perhaps been bitten by somthing and had an allergic reaction. She had another incidence of slight swelling again....we still were not sure why. Then she had her 2nd men B shot and things went crazy....she had difficulty walking....her legs would swell and she got papura on her legs as well...they started testing her for everything....and eventually decided she had vasculitis. She was put on prednisone for 6 months and all was fairly okay....taken off and it was discovered that her liver readings were really high and a few months later she was diagnosed with PSC/UC. I really believe that if you have a genetic pre-disposition to this sort of thing and then have an innoculation of any kiind it can cause your immune system to jump start and then all the auto-immune diseases kick in. Just my theory...but I believe quite strongly as well that the innoculation kicked started it all. My daughter may have developed PSC later on in life....but at this young age to go from a healthy 16 year old to what she is now is just unbelievable to me!! When reading about polyarteritis on the interenet it sounded like a terrible disease....PSC?UC sounded good next to it!!! I am really freaked out....still no positive diagnosis. To answer one of the other questions.....her pain after eating has just gotten progressively worse.......she would not eat because she did not want to eperience the pain. I put her on pro-biotics and L-glutemine....and that seemed to relieve some of the pain. She was admitted to hospital this time because of GI bleediing. She had a TIPS procedure in June and they now discovered it was blocked.....so unblocked it. Has anyone actually had polyarteritis????I would really like to know that it is not as bad as it sounds!!!! We may have a diagnosis tomorrow........please pray for my daughter.Thanks.Gwynn Quote Link to comment Share on other sites More sharing options...
Guest guest Posted December 15, 2008 Report Share Posted December 15, 2008 Thanks to all of you for your input regarding my daughter. She had the Hepatitis B shots when she was about 10 when we moved to Florida and they required that she have them to attend school there. She has since been tested for Hepatitis B but does not have it. , I am convinced my daughter contracted vasculitis, PSC and UC after she had a meningitis shot in New Zealand. We were living there at the time and Men B is quite a problem over there.....so not thinking to much about it she had the shot. 2 weeks later she developed a swollen ankle and we had no idea why, and thought she had perhaps been bitten by somthing and had an allergic reaction. She had another incidence of slight swelling again....we still were not sure why. Then she had her 2nd men B shot and things went crazy....she had difficulty walking....her legs would swell and she got papura on her legs as well...they started testing her for everything....and eventually decided she had vasculitis. She was put on prednisone for 6 months and all was fairly okay....taken off and it was discovered that her liver readings were really high and a few months later she was diagnosed with PSC/UC. I really believe that if you have a genetic pre-disposition to this sort of thing and then have an innoculation of any kiind it can cause your immune system to jump start and then all the auto-immune diseases kick in. Just my theory...but I believe quite strongly as well that the innoculation kicked started it all. My daughter may have developed PSC later on in life....but at this young age to go from a healthy 16 year old to what she is now is just unbelievable to me!! When reading about polyarteritis on the interenet it sounded like a terrible disease....PSC?UC sounded good next to it!!! I am really freaked out....still no positive diagnosis. To answer one of the other questions.....her pain after eating has just gotten progressively worse.......she would not eat because she did not want to eperience the pain. I put her on pro-biotics and L-glutemine....and that seemed to relieve some of the pain. She was admitted to hospital this time because of GI bleediing. She had a TIPS procedure in June and they now discovered it was blocked.....so unblocked it. Has anyone actually had polyarteritis????I would really like to know that it is not as bad as it sounds!!!! We may have a diagnosis tomorrow........please pray for my daughter.Thanks.Gwynn Quote Link to comment Share on other sites More sharing options...
Guest guest Posted December 16, 2008 Report Share Posted December 16, 2008 Thanks for the kind words and support. My daughter is still in hospital They were meant to do a colonoscopy today but she was running a fever when she woke up so they postponed it to tomorrow. The diagnosis for polyarteritis is still in up in the air. I am hoping and praying that she does not have it. If not, the main question is why does she experience intense pain 1/2 hour after eating? She does not want to eat as she anticipates the pain that will come after wards. Is there anyone else out there that has a lot of abdominal pain, and if so do you know what causes it?? One of the symptoms of polyarteritis is severe abdominal pain but she does not really have any of the other symptoms. Anyway if anyone has some experience with this I would be happy to hear about it. Gwynn (Mom of daughter 19 vasculitis 2005, PSC/UC 2006 TX) Quote Link to comment Share on other sites More sharing options...
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