question about liver enzymes

[Guest guest]

My son was first diagnosed with PSC and UC a year ago when all his

liver enzymes were very high,and the ERCP confirmed the PSC.

He has spent the year trying to get his colitis under control and after

dropping 50 pounds and not responding to all the typical medications,

his diarrhea and weight loss seem to be starting to respond to humira.

He had a blood test done in Dec. (he had been off all drugs for a month

and hadn't started humira or urso yet) and all the liver enzymes are

normal on that blood test. Is that typical that they would fluctuate

from very high to normal . . . or might his changes to his diet be

actually helping.

Do PSC patients often have liver enzymes return to normal levels?

[Guest guest]

For me diet did have some impact, but I

did swing from high to almost normal liver enzymes more than once. It did

not happen often – maybe three times in 17 years, but it did

happen. PSC is different for all people to some extent. I know that

there is some knowledge that suggests gluten free diets help keep PSC in better

control. When my PSC was most symptom free, I was using wheat germ and

bran for the fiber in my diet.

Was your son on antibiotics for the

UC? That may well have reduced the PSC inflammation and his liver

enzymes. I believe that when either PSC or UC is flaring the other

condition tends to be problematic too. Just a thought.

Joe

PSC & UC -

1990; Liver Transplant - 2007

My son was first diagnosed with PSC and UC a year ago

when all his

liver enzymes were very high,and the ERCP confirmed the PSC.

He has spent the year trying to get his colitis under control and after

dropping 50 pounds and not responding to all the typical medications,

his diarrhea and weight loss seem to be starting to respond to humira.

He had a blood test done in Dec. (he had been off all drugs for a month

and hadn't started humira or urso yet) and all the liver enzymes are

normal on that blood test. Is that typical that they would fluctuate

from very high to normal . . . or might his changes to his diet be

actually helping.

Do PSC patients often have liver enzymes return to normal levels?

[Guest guest]

For me diet did have some impact, but I

did swing from high to almost normal liver enzymes more than once. It did

not happen often – maybe three times in 17 years, but it did

happen. PSC is different for all people to some extent. I know that

there is some knowledge that suggests gluten free diets help keep PSC in better

control. When my PSC was most symptom free, I was using wheat germ and

bran for the fiber in my diet.

Was your son on antibiotics for the

UC? That may well have reduced the PSC inflammation and his liver

enzymes. I believe that when either PSC or UC is flaring the other

condition tends to be problematic too. Just a thought.

Joe

PSC & UC -

1990; Liver Transplant - 2007

My son was first diagnosed with PSC and UC a year ago

when all his

liver enzymes were very high,and the ERCP confirmed the PSC.

He has spent the year trying to get his colitis under control and after

dropping 50 pounds and not responding to all the typical medications,

his diarrhea and weight loss seem to be starting to respond to humira.

He had a blood test done in Dec. (he had been off all drugs for a month

and hadn't started humira or urso yet) and all the liver enzymes are

normal on that blood test. Is that typical that they would fluctuate

from very high to normal . . . or might his changes to his diet be

actually helping.

Do PSC patients often have liver enzymes return to normal levels?

[Guest guest]

For me diet did have some impact, but I

did swing from high to almost normal liver enzymes more than once. It did

not happen often – maybe three times in 17 years, but it did

happen. PSC is different for all people to some extent. I know that

there is some knowledge that suggests gluten free diets help keep PSC in better

control. When my PSC was most symptom free, I was using wheat germ and

bran for the fiber in my diet.

Was your son on antibiotics for the

UC? That may well have reduced the PSC inflammation and his liver

enzymes. I believe that when either PSC or UC is flaring the other

condition tends to be problematic too. Just a thought.

Joe

PSC & UC -

1990; Liver Transplant - 2007

My son was first diagnosed with PSC and UC a year ago

when all his

liver enzymes were very high,and the ERCP confirmed the PSC.

He has spent the year trying to get his colitis under control and after

dropping 50 pounds and not responding to all the typical medications,

his diarrhea and weight loss seem to be starting to respond to humira.

He had a blood test done in Dec. (he had been off all drugs for a month

and hadn't started humira or urso yet) and all the liver enzymes are

normal on that blood test. Is that typical that they would fluctuate

from very high to normal . . . or might his changes to his diet be

actually helping.

Do PSC patients often have liver enzymes return to normal levels?