Guest guest Posted March 5, 2009 Report Share Posted March 5, 2009 I was tested for pANCA, but not for PSC. It was about 7 years ago, and I was receiving Remicade and Imuran for CD. I developed some rheumatic symptoms and went to see a rheumatologist. She did several tests and diagnosed 'drug induced Lupus' which is an occasional side effect of Remicade treatment. I was not aware that the pANCA, which was positive, did not support that diagnosis, nor have anything to do with it. It was when I was being diagnosed with PSC last year, and a very astute NP decided to dog through my old labs, that the result was re-discovered, and of course fits right in with the PSC diagnosis. My PSC was missed by both the rheumatologist and my old GI. Hindsight is 20/20, because the indicators have been there for years. So to answer your question, my doctor's NP explained to me that PSC patients usually have a positive pANCA, however this positive result can appear in many other conditions. ee > > Have any of you been tested for this ? I was just looking at my latest immune tests and I was tested for it and it was negative- the Quote Link to comment Share on other sites More sharing options...
Guest guest Posted March 5, 2009 Report Share Posted March 5, 2009 Lori, I've had a few P ANCAs. For me they were/are looking for a type of vasculitis. It is not a dx test for PSC. There are several disease processes that positive PANCA is one marker. Hope that helps. (BTW) I do have a high P ANCA. Cheryl atypical pANCA > Have any of you been tested for this ? I was just looking at my latest immune tests and I was tested for it and it was negative- the notes on my labs says- > The atypical pANCA pattern has been observed in a significant percentage of patients with UC, PSC and autoimmune hepatitis. > > I know Braden hasn't been tested for this just the P ANCA and one dr was convinced he didn't have PSC because the test was negative- but it sounds like he ordered the wrong test ? I don't think you have to have a positive test for P ANCA to be diagnosed with PSC-it's just an indicator ?? That one doctor still keeps looking for indicators that Braden might not have PSC- even though he was the first to suggest he had it ?!? I don't know why he is looking for signs that he doesn't have PSC now.....but Braden seems to be stable with vancomycin and monthly IVIG infusions but i think it would be a HUGE mistake to try and dismiss all the evidence and now say- he doesn't have PSC KWIM ? > Braden has small duct PSC (early in the dx process) and increased EOS per biopsy , intrahepatic beading, repeated strictures after many dilations and stents for 3 years, thickening of intrahepatic duct walls, persistantly thickened common bile duct walls , classic LFT elevations that stabilized somewhat with urso, and classic PSC indicators on all of his MRCPs and ERCPs. > > Lori > lucky mom blessed with triplets > > > Quote Link to comment Share on other sites More sharing options...
Guest guest Posted March 5, 2009 Report Share Posted March 5, 2009 Lori, I've had a few P ANCAs. For me they were/are looking for a type of vasculitis. It is not a dx test for PSC. There are several disease processes that positive PANCA is one marker. Hope that helps. (BTW) I do have a high P ANCA. Cheryl atypical pANCA > Have any of you been tested for this ? I was just looking at my latest immune tests and I was tested for it and it was negative- the notes on my labs says- > The atypical pANCA pattern has been observed in a significant percentage of patients with UC, PSC and autoimmune hepatitis. > > I know Braden hasn't been tested for this just the P ANCA and one dr was convinced he didn't have PSC because the test was negative- but it sounds like he ordered the wrong test ? I don't think you have to have a positive test for P ANCA to be diagnosed with PSC-it's just an indicator ?? That one doctor still keeps looking for indicators that Braden might not have PSC- even though he was the first to suggest he had it ?!? I don't know why he is looking for signs that he doesn't have PSC now.....but Braden seems to be stable with vancomycin and monthly IVIG infusions but i think it would be a HUGE mistake to try and dismiss all the evidence and now say- he doesn't have PSC KWIM ? > Braden has small duct PSC (early in the dx process) and increased EOS per biopsy , intrahepatic beading, repeated strictures after many dilations and stents for 3 years, thickening of intrahepatic duct walls, persistantly thickened common bile duct walls , classic LFT elevations that stabilized somewhat with urso, and classic PSC indicators on all of his MRCPs and ERCPs. > > Lori > lucky mom blessed with triplets > > > Quote Link to comment Share on other sites More sharing options...
Guest guest Posted March 5, 2009 Report Share Posted March 5, 2009 Lori, I've had a few P ANCAs. For me they were/are looking for a type of vasculitis. It is not a dx test for PSC. There are several disease processes that positive PANCA is one marker. Hope that helps. (BTW) I do have a high P ANCA. Cheryl atypical pANCA > Have any of you been tested for this ? I was just looking at my latest immune tests and I was tested for it and it was negative- the notes on my labs says- > The atypical pANCA pattern has been observed in a significant percentage of patients with UC, PSC and autoimmune hepatitis. > > I know Braden hasn't been tested for this just the P ANCA and one dr was convinced he didn't have PSC because the test was negative- but it sounds like he ordered the wrong test ? I don't think you have to have a positive test for P ANCA to be diagnosed with PSC-it's just an indicator ?? That one doctor still keeps looking for indicators that Braden might not have PSC- even though he was the first to suggest he had it ?!? I don't know why he is looking for signs that he doesn't have PSC now.....but Braden seems to be stable with vancomycin and monthly IVIG infusions but i think it would be a HUGE mistake to try and dismiss all the evidence and now say- he doesn't have PSC KWIM ? > Braden has small duct PSC (early in the dx process) and increased EOS per biopsy , intrahepatic beading, repeated strictures after many dilations and stents for 3 years, thickening of intrahepatic duct walls, persistantly thickened common bile duct walls , classic LFT elevations that stabilized somewhat with urso, and classic PSC indicators on all of his MRCPs and ERCPs. > > Lori > lucky mom blessed with triplets > > > Quote Link to comment Share on other sites More sharing options...
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