High lifetime risk of cancer in PSC

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Two hundred and eleven patients were included, 143

(68%) were male and 126 (60%) had inflammatory bowel disease (IBD). Median

transplantation-free survival was 14 years. The risk of CCA after 10 and 20

years was 9% and 9%, respectively. In patients with concomitant IBD the 10-year

and 20-year risks for CRC were 14% and 31%, which was significantly higher than

for patients without IBD (2% and 2% (P = 0.008)).

CCA, cholangitis, and age at entry were independent

risk factors for the combined endpoint death or liver transplantation. Risk

factors for the endpoint death were CCA, CRC, age, and symptomatic presentation.

http://www.sciencedirect.com/science?_ob=ArticleURL & _udi=B6W7C-4TNTK8H-2 & _user=10 & _coverDate=01%2F31%2F2009 & _rdoc=25 & _fmt=high & _orig=browse & _srch=doc-info(%23toc%236623%232009%23999499998%23761094%23FLA%23display%23Volume) & _cdi=6623 & _sort=d & _docanchor= & _ct=40 & _acct=C000050221 & _version=1 & _urlVersion=0 & _userid=10 & md5=407922a16c95b8853cd06136ebd28ab4

Barb in Texas - Together in the Fight - Whatever it

Takes!

Son Ken (34) UC 91 PSC 99, LTX 6/21 & 6/30 2007

@ Baylor/Dallas