Researchers at the Heidelberg University Hospital discover new genetic disease / Gene mutation that triggers severe cirrhosis of the liver identified / Published in Hepatology

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Researchers at the Heidelberg University Hospital have discovered a new genetic disease

that can lead to severe liver damage. Because a protective component of the

bile is missing, the liver cells are exposed to the toxic components of the

bile, resulting in cirrhosis of liver, a transformation of liver cells into

connective tissue with a gradual loss of liver function. This could explain

some of the cases of liver cirrhosis of unknown origin and open up a new

approach for treatment. The research has now been published in the journal

“Hepatology”.

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