Re: MMP-3 gene link to PSC and Scoliosis...anybody else have both ?

[Guest guest]

I just read a report from a CT scan I had last year, and it made an

incidental note of " mild rotatory scoliosis " . I also noticed on another

report it said that I had degenerative bone disease, but my doctors

haven't really discussed either of these with me. I'll have to ask them

about it next time I go in especially since I've been having quite a bit

of back pain recently.

As far as I know I didn't have scoliosis, bone disease, or PSC as a kid

though, so this may not be the same thing...

athan

[Guest guest]

Hi Marna,

Had no idea there could be a connection. I’ve had trouble

with my spine forever, arthritis in hips, back, spine, fingers. Scoliosis. Had

both hips replaced at 51, but should have had that done several years before I did.

Motion in my hips was severely limited for about 7 years before I became the

bionic woman.

I looked up MMP-3 on the web, and it seems to be connected to

both arthritis and scoliosis as well as PSC. I wonder how you can get the mmp-3

gene tested to see if you have the anomaly.

Nita

From:

[mailto: ] On Behalf

Of moranclan07

Just wondered who else in this group may have both diseases ???

MARNA and WESLEY ( almost 14....13 years of PSC ...third stage or

worse)

[Guest guest]

Hi Marna,

Had no idea there could be a connection. I’ve had trouble

with my spine forever, arthritis in hips, back, spine, fingers. Scoliosis. Had

both hips replaced at 51, but should have had that done several years before I did.

Motion in my hips was severely limited for about 7 years before I became the

bionic woman.

I looked up MMP-3 on the web, and it seems to be connected to

both arthritis and scoliosis as well as PSC. I wonder how you can get the mmp-3

gene tested to see if you have the anomaly.

Nita

From:

[mailto: ] On Behalf

Of moranclan07

Just wondered who else in this group may have both diseases ???

MARNA and WESLEY ( almost 14....13 years of PSC ...third stage or

worse)

[Guest guest]

Although I am an adult I have been fighting degenerative disc and

joint disease since I was 13 and I have adult onset Scoliosis, not

bad though, just enough of a twist to get the diagnosis, along with

the PSC. Most of my joints are effected by the degeneration but it

is not considered RA and I have consistently tested NEgative for RA.

No one has ever tied the two together for me.

Dawn

>

> Hi,

>

> Wesley has had PSC since he was 1 years old ( very rare ).

Ulcerative

> Colitis at the same time. I read that the MMP-3 gene etc etc etc

> reasearch links this to a susceptibility to PSC.

>

> Now Wesley has Adolescent Scoliosis which can be caused by the

same

> MMP-3 gene problem which causes inflammation in the bones ( just

like

> the liver )and causes degenerative bone disease which in turn

causes

> scoliosis.

>

> I am taking him to s Hopkins ASAP!

>

> Just wondered who else in this group may have both diseases ???

>

> MARNA and WESLEY ( almost 14....13 years of PSC ...third stage or

> worse)

>

[Guest guest]

Although I am an adult I have been fighting degenerative disc and

joint disease since I was 13 and I have adult onset Scoliosis, not

bad though, just enough of a twist to get the diagnosis, along with

the PSC. Most of my joints are effected by the degeneration but it

is not considered RA and I have consistently tested NEgative for RA.

No one has ever tied the two together for me.

Dawn

>

> Hi,

>

> Wesley has had PSC since he was 1 years old ( very rare ).

Ulcerative

> Colitis at the same time. I read that the MMP-3 gene etc etc etc

> reasearch links this to a susceptibility to PSC.

>

> Now Wesley has Adolescent Scoliosis which can be caused by the

same

> MMP-3 gene problem which causes inflammation in the bones ( just

like

> the liver )and causes degenerative bone disease which in turn

causes

> scoliosis.

>

> I am taking him to s Hopkins ASAP!

>

> Just wondered who else in this group may have both diseases ???

>

> MARNA and WESLEY ( almost 14....13 years of PSC ...third stage or

> worse)

>

[Guest guest]

My younger brother who has UC diagnosed about 20 years go when he was

35, had scoliosis as a teenager.

My sister and he have UC, I just have PSC.

> > MMP-3 gene problem which causes inflammation in the bones ( just

> like

> > the liver )and causes degenerative bone disease which in turn

> causes

> > scoliosis.