Re: question: regarding previous info , cant ove...

[Guest guest]

> In a message dated 3/18/2005 1:02:27 PM Eastern Standard Time,

> emugirls@y... writes:

>

> > any chance you know exactly " which studies " , or be able to quote

them?

> >

Try the following link.

http://www.ncbi.nlm.nih.gov/books/bv.fcgi?rid=endocrin.section.33

Particuarilly the bottom paragraph explains a little more. Your doc

will probably notice that this is a text book used to teach doctors

endocrinology, so its pretty factual. The problem you are going to

run into is 1) that this is strictly theoretical; 2) like it says in

the paragraph if it were true in all cases small deceases in the

hormone would not theoretically lead to symptoms.....this would count

on #3; 3) is thyroid hormone self regulating itself by producing its

own receptors, see below for a little more on this.

I was looking to give you the names of the gene that actaully produce

the thyroid hormone receptors but I cannot find them, sorry, I do

know that the alpha receptors are produced from a gene on chromosome

17 and the beta receptors are produced from a gene on chromosome 3,

if you get the chance ask your doc if he knows if they are self

regulating....it will probably show him that you are looking

seriously into this and also I don't have the answer and would like

it. LOL

To explain #3 a little more......the thyroid recptors, the ones that

have been pretty thourghly studied, work in two ways transcription

and repression or silenceing of a gene. Transcription means that the

receptor is actually on the membrane of the cell nucleus where it

will bind to the hormone and then take a ride all the way to center

of the neclues where it will ultimately bind to your actual DNA. It

picks up a couple other molecules on the way so that it can do this

but thats not important right now. Once it binds to the DNA what it

does is unravel it and slides down a gene where it will duplicate

that gene and sends out what they call mRNA back out to the the fluid

of the cell. Once the mRNA is back out in the cell ribosome,

basically a sugar molecule, will do the same thing to the mRNA that

the receptor did to your DNA....unravels it and makes a protein

strand. This protein strands are things like serotonin, growth

hormone etc etc etc....... So far they have found 198 different

genes that thyroid hormone express, I beleieve that it is more than

that but that was one papaer I read. What I meant by self regualting

is that I don't know if one of the protein strands they put out is

the actual thyroid hormone receptor itself.

I also said that they work by repression, basically they can tell a

cell to stop making protein strands. The receptor that does this is

primarily the beta 2 receptor, if I remember correctly. They are

most abundant in the hypothalimus, so they are probably the ones that

tell your body to stop putting out TSH. Theyu are also pretty

abundant in the liver and kidneys but they do not know the most

likely use for them in those organs yet. Hope this helps.