Endocrinologists and Levoxl

March 18, 2005

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>>>>snip

A full seven months after the entry of generic competition, Levoxyl®

has

maintained approximately 65% of its prescription base prior to the onset of

generic competition, which is well-ahead of the percentage most branded

pharmaceutical products typically retain. The Company believes that this is

because Levoxyl® is recognized to have a narrow therapeutic index with

significant clinical consequences of excessive or inadequate treatment,

combined with an aggressive program of discounts and rebates. In a joint

statement, The American Thyroid Association, The Endocrine Society, and the

American Association of Clinical Endocrinologists raised concerns regarding

patients being switched among a number of levothyroxine sodium preparations.

Accordingly, these organizations advised physicians caring for patients on

levothyroxine sodium therapy to encourage their patients to ask to remain on

their current levothyroxine sodium preparation. This joint statement is

>>>>snip About Levoxyl®

Levoxyl® is indicated for thyroid hormone replacement or supplemental

therapy for hypothyroidism. Levoxyl® is contraindicated in patients with

untreated thyrotoxicosis, uncorrected adrenal insufficiency, or

hypersensitivity to any of its inactive ingredients. Adverse reactions are

primarily those of hyperthyroidism due to overdose. Use with caution in

patients with cardiovascular disease. Thyroid hormones, including Levoxyl®

either alone or together with other therapeutic agents, should not be used

for

the treatment of obesity. In euthyroid patients, doses within the range of

daily hormonal requirements are ineffective for weight reduction. Larger

doses

may produce serious or even life-threatening manifestations of toxicity,

particularly when given in association with sympathomimetic amines such as

those used for anorectic effects

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Thyroid-Adrenal Connection Information & Resources

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