More on BEING SHORT & Thyroid Hormone Resistance

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Patients with resistance to thyroid hormone, on average, were

shorter and weighed less than those without resistance; 18% had

short stature (defined as height no greater than the fifth

percentile), and the mean IQ of this 18% was lower than that in

persons with resistance to thyroid hormone who were of normal height

(82 compared with 94; P equals 0.0004). Bone age was delayed in 29%

of children with resistance to thyroid hormone; low weight was

present in one third of children with resistance. In persons with

resistance to thyroid hormone, there was a negative correlation

between the percentile of the weight and basal metabolic rate (r

equals minus 0.52; P less than 0.01) and between the percentile of

weight and free T4 levels (r equals minus 0.34; P equals 0.002).

There was a positive correlation between percentile of weight and

age (r equals 0.45; P less than 0.0001). Basal metabolic rate and

ankle reflex did not differ between persons with and without

resistance to thyroid hormone