Guest guest Posted February 18, 2009 Report Share Posted February 18, 2009 Dave - Where is Uppsala University? Interesting information! Thank you. Joanne H (, Ca., mom of Joe, UC/PSC 2-06) Title: Autoantigens in Inflammatory Bowel Disease and Primary Sclerosing Cholangitis Department: Uppsala University, Medicinska vetenskapsområdet, Faculty of Medicine, Department of Medical Sciences .. Quote Link to comment Share on other sites More sharing options...
Guest guest Posted February 18, 2009 Report Share Posted February 18, 2009 Dave - Where is Uppsala University? Interesting information! Thank you. Joanne H (, Ca., mom of Joe, UC/PSC 2-06) Title: Autoantigens in Inflammatory Bowel Disease and Primary Sclerosing Cholangitis Department: Uppsala University, Medicinska vetenskapsområdet, Faculty of Medicine, Department of Medical Sciences .. Quote Link to comment Share on other sites More sharing options...
Guest guest Posted February 18, 2009 Report Share Posted February 18, 2009 Hi Joanne; It's in Uppsala, Sweden. I wrote to the author, Brita Ardesjö, about 1 month ago to congratulate her on her thesis, and to mention that if she will be continuing to pursue research in PSC she might consider submitting a proposal to PSC Partners Seeking a Cure in the future, and to ask if she would be willing to share a preprint when the Pdzk1 autoantibody work is published. However, I havn't heard back from her. Best regards, Dave R. > Where is Uppsala University? Quote Link to comment Share on other sites More sharing options...
Guest guest Posted February 18, 2009 Report Share Posted February 18, 2009 Hi Joanne; It's in Uppsala, Sweden. I wrote to the author, Brita Ardesjö, about 1 month ago to congratulate her on her thesis, and to mention that if she will be continuing to pursue research in PSC she might consider submitting a proposal to PSC Partners Seeking a Cure in the future, and to ask if she would be willing to share a preprint when the Pdzk1 autoantibody work is published. However, I havn't heard back from her. Best regards, Dave R. > Where is Uppsala University? Quote Link to comment Share on other sites More sharing options...
Guest guest Posted February 19, 2009 Report Share Posted February 19, 2009 Dave, I personally always appreciate that you share the knowledge with us. I get the majority of my education from you, and it saves me a lot of money - money that I'd have to spend on medical school. :0) Thank you so much, MO Access 350+ FREE radio stations anytime from anywhere on the web. Get the Radio Toolbar! Quote Link to comment Share on other sites More sharing options...
Guest guest Posted February 19, 2009 Report Share Posted February 19, 2009 Dave, I personally always appreciate that you share the knowledge with us. I get the majority of my education from you, and it saves me a lot of money - money that I'd have to spend on medical school. :0) Thank you so much, MO Access 350+ FREE radio stations anytime from anywhere on the web. Get the Radio Toolbar! Quote Link to comment Share on other sites More sharing options...
Guest guest Posted February 19, 2009 Report Share Posted February 19, 2009 Dave, I personally always appreciate that you share the knowledge with us. I get the majority of my education from you, and it saves me a lot of money - money that I'd have to spend on medical school. :0) Thank you so much, MO Access 350+ FREE radio stations anytime from anywhere on the web. Get the Radio Toolbar! Quote Link to comment Share on other sites More sharing options...
Guest guest Posted February 19, 2009 Report Share Posted February 19, 2009 Hi Dave, Thanks very much for always supplying the PSC group with valuable information! Please don't stop. Lori A. "Aggressively Pursuing Solutions To Your Real Estate Needs!" First Weber Group Cell: 1507 E. Sunset Drive Waukesha, WI 53189 LoriUSA@... www.Lori.FirstWeber.com To: Sent: Wednesday, February 18, 2009 10:12:47 PMSubject: Interesting new lead At the outset I'd like to apologize in advance if this post is too scientific. But I'm always on the look out for new leads in the PSC area, and this one caught my attention. It's a thesis from Uppsala University: Author: Ardesjö, Brita Title: Autoantigens in Inflammatory Bowel Disease and Primary Sclerosing Cholangitis Department: Uppsala University, Medicinska vetenskapsområ det, Faculty of Medicine, Department of Medical Sciences http://publications .uu.se/theses/ abstract. xsql?dbid= 8677 In a nutshell it describes some new autoantibodies identified in PSC patients. The autoantibody that is most interesting is an antibody against a protein called Pdzk1. This is a protein that regulates the cystic fibrosis transmembrane conductance regulator (CFTR) protein that is responsible for bicarbonate excretion into the bile. You will recall that the liver disease associated with cystic fibrosis is very similar to primary sclerosing cholangitis, and that some researchers have shown that the CFTR gene may be defective in some PSC patients. Recent studies with children with PSC have intriguingly shown impaired CFTR activity without any obvious mutations in the CFTR gene, indicating that a protein regulating CFTR may be affected in these patients. Perhaps development of antibodies against Pdzk1 could somehow result in impaired CFTR activity, disrupting bile flow? Dave (father of (23); PSC 07/03; UC 08/03) Quote Link to comment Share on other sites More sharing options...
Guest guest Posted February 19, 2009 Report Share Posted February 19, 2009 Very interesting ! Several doctors have questioned if Braden has cystic fibrosis so this is intriguing to me that there may be a connection somehow. When my tylenol kicks in (taken to deal with all of the medical crap I have been dealing with today..) I will read the article Thanks again for all that you do for everyone here !!! Lori lucky mom blessed with triplets www.caringbridge.org/visit/bradenwild > > > At the outset I'd like to apologize in advance if this post is too > scientific. But I'm always on the look out for new leads in the PSC > area, and this one caught my attention. It's a thesis from Uppsala > University: > > Author: Ardesjö, Brita Title: Autoantigens in Inflammatory Bowel > Disease and Primary Sclerosing Cholangitis Department: Uppsala > University, Medicinska vetenskapsområdet, Faculty of Medicine, > Department of Medical Sciences > > http://publications.uu.se/theses/abstract.xsql?dbid=8677 > http://publications.uu.se/theses/abstract.xsql?dbid=8677> > > In a nutshell it describes some new autoantibodies identified in PSC > patients. The autoantibody that is most interesting is an antibody > against a protein called Pdzk1. This is a protein that regulates the > cystic fibrosis transmembrane conductance regulator (CFTR) protein that > is responsible for bicarbonate excretion into the bile. You will recall > that the liver disease associated with cystic fibrosis is very similar > to primary sclerosing cholangitis, and that some researchers have shown > that the CFTR gene may be defective in some PSC patients. Recent > studies with children with PSC have intriguingly shown impaired CFTR > activity without any obvious mutations in the CFTR gene, indicating that > a protein regulating CFTR may be affected in these patients. Perhaps > development of antibodies against Pdzk1 could somehow result in impaired > CFTR activity, disrupting bile flow? > > Dave > > (father of (23); PSC 07/03; UC 08/03) > Quote Link to comment Share on other sites More sharing options...
Guest guest Posted February 19, 2009 Report Share Posted February 19, 2009 Very interesting ! Several doctors have questioned if Braden has cystic fibrosis so this is intriguing to me that there may be a connection somehow. When my tylenol kicks in (taken to deal with all of the medical crap I have been dealing with today..) I will read the article Thanks again for all that you do for everyone here !!! Lori lucky mom blessed with triplets www.caringbridge.org/visit/bradenwild > > > At the outset I'd like to apologize in advance if this post is too > scientific. But I'm always on the look out for new leads in the PSC > area, and this one caught my attention. It's a thesis from Uppsala > University: > > Author: Ardesjö, Brita Title: Autoantigens in Inflammatory Bowel > Disease and Primary Sclerosing Cholangitis Department: Uppsala > University, Medicinska vetenskapsområdet, Faculty of Medicine, > Department of Medical Sciences > > http://publications.uu.se/theses/abstract.xsql?dbid=8677 > http://publications.uu.se/theses/abstract.xsql?dbid=8677> > > In a nutshell it describes some new autoantibodies identified in PSC > patients. The autoantibody that is most interesting is an antibody > against a protein called Pdzk1. This is a protein that regulates the > cystic fibrosis transmembrane conductance regulator (CFTR) protein that > is responsible for bicarbonate excretion into the bile. You will recall > that the liver disease associated with cystic fibrosis is very similar > to primary sclerosing cholangitis, and that some researchers have shown > that the CFTR gene may be defective in some PSC patients. Recent > studies with children with PSC have intriguingly shown impaired CFTR > activity without any obvious mutations in the CFTR gene, indicating that > a protein regulating CFTR may be affected in these patients. Perhaps > development of antibodies against Pdzk1 could somehow result in impaired > CFTR activity, disrupting bile flow? > > Dave > > (father of (23); PSC 07/03; UC 08/03) > Quote Link to comment Share on other sites More sharing options...
Guest guest Posted February 19, 2009 Report Share Posted February 19, 2009 Very interesting ! Several doctors have questioned if Braden has cystic fibrosis so this is intriguing to me that there may be a connection somehow. When my tylenol kicks in (taken to deal with all of the medical crap I have been dealing with today..) I will read the article Thanks again for all that you do for everyone here !!! Lori lucky mom blessed with triplets www.caringbridge.org/visit/bradenwild > > > At the outset I'd like to apologize in advance if this post is too > scientific. But I'm always on the look out for new leads in the PSC > area, and this one caught my attention. It's a thesis from Uppsala > University: > > Author: Ardesjö, Brita Title: Autoantigens in Inflammatory Bowel > Disease and Primary Sclerosing Cholangitis Department: Uppsala > University, Medicinska vetenskapsområdet, Faculty of Medicine, > Department of Medical Sciences > > http://publications.uu.se/theses/abstract.xsql?dbid=8677 > http://publications.uu.se/theses/abstract.xsql?dbid=8677> > > In a nutshell it describes some new autoantibodies identified in PSC > patients. The autoantibody that is most interesting is an antibody > against a protein called Pdzk1. This is a protein that regulates the > cystic fibrosis transmembrane conductance regulator (CFTR) protein that > is responsible for bicarbonate excretion into the bile. You will recall > that the liver disease associated with cystic fibrosis is very similar > to primary sclerosing cholangitis, and that some researchers have shown > that the CFTR gene may be defective in some PSC patients. Recent > studies with children with PSC have intriguingly shown impaired CFTR > activity without any obvious mutations in the CFTR gene, indicating that > a protein regulating CFTR may be affected in these patients. Perhaps > development of antibodies against Pdzk1 could somehow result in impaired > CFTR activity, disrupting bile flow? > > Dave > > (father of (23); PSC 07/03; UC 08/03) > Quote Link to comment Share on other sites More sharing options...
Guest guest Posted February 19, 2009 Report Share Posted February 19, 2009 Keep in mind folks had to have the lung tx due to "Idiopathic Pulmonary Fibrosis". He also showed fibrosis on a skin biopsy besides the "Bridging Portal Fibrosis" in his liver. Obviously something systemic there. AmiSent from my BlackBerry Smartphone provided by AlltelFrom: "wildwildtrips" Date: Thu, 19 Feb 2009 20:26:49 -0000To: < >Subject: Re: Interesting new lead Very interesting ! Several doctors have questioned if Braden has cystic fibrosis so this is intriguing to me that there may be a connection somehow. When my tylenol kicks in (taken to deal with all of the medical crap I have been dealing with today..) I will read the article Thanks again for all that you do for everyone here !!! Lori lucky mom blessed with triplets www.caringbridge.org/visit/bradenwild > > > At the outset I'd like to apologize in advance if this post is too > scientific. But I'm always on the look out for new leads in the PSC > area, and this one caught my attention. It's a thesis from Uppsala > University: > > Author: Ardesjö, Brita Title: Autoantigens in Inflammatory Bowel > Disease and Primary Sclerosing Cholangitis Department: Uppsala > University, Medicinska vetenskapsområdet, Faculty of Medicine, > Department of Medical Sciences > > http://publications.uu.se/theses/abstract.xsql?dbid=8677 > <http://publications.uu.se/theses/abstract.xsql?dbid=8677> > > In a nutshell it describes some new autoantibodies identified in PSC > patients. The autoantibody that is most interesting is an antibody > against a protein called Pdzk1. This is a protein that regulates the > cystic fibrosis transmembrane conductance regulator (CFTR) protein that > is responsible for bicarbonate excretion into the bile. You will recall > that the liver disease associated with cystic fibrosis is very similar > to primary sclerosing cholangitis, and that some researchers have shown > that the CFTR gene may be defective in some PSC patients. Recent > studies with children with PSC have intriguingly shown impaired CFTR > activity without any obvious mutations in the CFTR gene, indicating that > a protein regulating CFTR may be affected in these patients. Perhaps > development of antibodies against Pdzk1 could somehow result in impaired > CFTR activity, disrupting bile flow? > > Dave > > (father of (23); PSC 07/03; UC 08/03) > Quote Link to comment Share on other sites More sharing options...
Guest guest Posted February 19, 2009 Report Share Posted February 19, 2009 Keep in mind folks had to have the lung tx due to "Idiopathic Pulmonary Fibrosis". He also showed fibrosis on a skin biopsy besides the "Bridging Portal Fibrosis" in his liver. Obviously something systemic there. AmiSent from my BlackBerry Smartphone provided by AlltelFrom: "wildwildtrips" Date: Thu, 19 Feb 2009 20:26:49 -0000To: < >Subject: Re: Interesting new lead Very interesting ! Several doctors have questioned if Braden has cystic fibrosis so this is intriguing to me that there may be a connection somehow. When my tylenol kicks in (taken to deal with all of the medical crap I have been dealing with today..) I will read the article Thanks again for all that you do for everyone here !!! Lori lucky mom blessed with triplets www.caringbridge.org/visit/bradenwild > > > At the outset I'd like to apologize in advance if this post is too > scientific. But I'm always on the look out for new leads in the PSC > area, and this one caught my attention. It's a thesis from Uppsala > University: > > Author: Ardesjö, Brita Title: Autoantigens in Inflammatory Bowel > Disease and Primary Sclerosing Cholangitis Department: Uppsala > University, Medicinska vetenskapsområdet, Faculty of Medicine, > Department of Medical Sciences > > http://publications.uu.se/theses/abstract.xsql?dbid=8677 > <http://publications.uu.se/theses/abstract.xsql?dbid=8677> > > In a nutshell it describes some new autoantibodies identified in PSC > patients. The autoantibody that is most interesting is an antibody > against a protein called Pdzk1. This is a protein that regulates the > cystic fibrosis transmembrane conductance regulator (CFTR) protein that > is responsible for bicarbonate excretion into the bile. You will recall > that the liver disease associated with cystic fibrosis is very similar > to primary sclerosing cholangitis, and that some researchers have shown > that the CFTR gene may be defective in some PSC patients. Recent > studies with children with PSC have intriguingly shown impaired CFTR > activity without any obvious mutations in the CFTR gene, indicating that > a protein regulating CFTR may be affected in these patients. Perhaps > development of antibodies against Pdzk1 could somehow result in impaired > CFTR activity, disrupting bile flow? > > Dave > > (father of (23); PSC 07/03; UC 08/03) > Quote Link to comment Share on other sites More sharing options...
Guest guest Posted February 21, 2009 Report Share Posted February 21, 2009 Hi Dave, Do you (we, group) have any contact in Uppsala or near it in Sweden who could just give Brita Ardesjö a call and ask her directly or via their own hepatologist about the possibility to reprint the article? I am still a bit unsure how well the PSC Partners Seeking a Cure is known " around here " , even among hepatologists. Is there anyone in this group from Sweden or Uppsala? When I contacted a Finnish hepatologist new to me for the first time, it took more than a month to get the response. The third time I emailed him a question, he only answered it when we met (on Thursday) but he remembered it. Maybe it is typical of the Scandinavian drs/researches? I hope you get the response soon! Taru-Mari (from Finland), mom of Eemeli (12), PSC 7/2003 & UC 5/2008 > > Hi Joanne; > > It's in Uppsala, Sweden. I wrote to the author, Brita Ardesjö, about 1 month ago to congratulate her on her thesis, and to mention that if she will be continuing to pursue research in PSC she might consider submitting a proposal to PSC Partners Seeking a Cure in the future, and to ask if she would be willing to share a preprint when the Pdzk1 autoantibody work is published. However, I havn't heard back from her. > > Best regards, > > Dave R. Quote Link to comment Share on other sites More sharing options...
Guest guest Posted February 21, 2009 Report Share Posted February 21, 2009 Hi Dave, Do you (we, group) have any contact in Uppsala or near it in Sweden who could just give Brita Ardesjö a call and ask her directly or via their own hepatologist about the possibility to reprint the article? I am still a bit unsure how well the PSC Partners Seeking a Cure is known " around here " , even among hepatologists. Is there anyone in this group from Sweden or Uppsala? When I contacted a Finnish hepatologist new to me for the first time, it took more than a month to get the response. The third time I emailed him a question, he only answered it when we met (on Thursday) but he remembered it. Maybe it is typical of the Scandinavian drs/researches? I hope you get the response soon! Taru-Mari (from Finland), mom of Eemeli (12), PSC 7/2003 & UC 5/2008 > > Hi Joanne; > > It's in Uppsala, Sweden. I wrote to the author, Brita Ardesjö, about 1 month ago to congratulate her on her thesis, and to mention that if she will be continuing to pursue research in PSC she might consider submitting a proposal to PSC Partners Seeking a Cure in the future, and to ask if she would be willing to share a preprint when the Pdzk1 autoantibody work is published. However, I havn't heard back from her. > > Best regards, > > Dave R. Quote Link to comment Share on other sites More sharing options...
Recommended Posts
Join the conversation
You are posting as a guest. If you have an account, sign in now to post with your account.
Note: Your post will require moderator approval before it will be visible.