Guest guest Posted March 8, 2005 Report Share Posted March 8, 2005 This explains SOOOooo much. I have been under herrendous stress from mercury illness and some other things to boot. My question is, under the circumstances, I do not see a reason to take T4 at all. It seems to me that taking T3 only would be a better approach for me. I looked at the site for WILSON'S T3 and it makes sense for everything except that I can not afford to try it. ~Inga on 2/20/05 4:14 PM, *~ OM ~* at OM@... wrote: > > > > MORE THYROID INFORMATION > > http://drguberman.com/news.cfm?date_range=8/01/04 > > Armour and Thyrolar both contain 38 mcg of T4 and 9 mcg of T3. This is 4 > parts T4 to 1 part T3 (the exact ratio is 4.22 to 1). Some endocrinologists > now advocate the use of products containing both T4 and T3, but they > recommend a higher T4 to T3 ratio. They prefer a ratio 10 parts T4 to 1 part > T3. The lower T3 content of such products renders them far less effective > than Armour and Thyrolar. In our clinical experience, the treatment outcome > is inferior for patients who use products with the lower T3 content. The > inferior treatment outcome is supported by two recent studies conducted by > endocrinologists.[1][2] The studies showed that patients who added only a > small amount of T3 to their T4 continued to suffer from symptoms, just as > did patients who used T4 alone. The ratios of T4 to T3 the patients used > varied, but most used a higher T4 to T3 ration than in Armour and Thyrolar. > Of course, the endocrinologists restricted the patients' dosages according > to their TSH and thyroid hormone levels, and this almost guaranteed that the > patients took too little thyroid hormone and continued to suffer from > hypothyroid symptoms. If a new dose of Armour contains too little T4 and T3 > to benefit you, you’ll have to go through another evaluation period. And > you’ll have to do this again and again until you find what I call your > therapeutic window " —a small dosage range that optimally benefits you without > overstimulating you. That optimal dosage range is highly individual, but > historically, the typical patient’s therapeutic window has been somewhere > between 120 to 240 mg (2 to 4 grains). There’s no way to accurately predict > what your therapeutic window is. Until you find it, you may not improve much > from the Armour. But once you do, you’re likely to feel that the wait was > well worth it. > > The thyroid gland secretes mostly T4 and very little T3. Most of the T3 that > drives cell metabolism is produced by action of the enzyme named 5 > -deiodinase, which converts T4 to T3. (We pronounce the " 5'- " as " five-prime > " ) Without this conversion of T4 to T3, cells have too little T3 to maintain > normal metabolism; metabolism then slows down. T3, therefore, is the > metabolically active thyroid hormone. For the most part, T4 is metabolically > inactive. T4 " drives " metabolism only after the deiodinase enzyme converts > it to T3. > > Another enzyme called 5-deiodinase continually converts some T4 to > reverse-T3. Reverse-T3 does not stimulate metabolism. It is produced as a > way to help clear some T4 from the body. > > Under normal conditions, cells continually convert about 40% of T4 to T3. > They convert about 60% of T4 to reverse-T3. Hour-by-hour, conversion of T4 > continues with slight shifts in the percentage of T4 converted to T3 and > reverse-T3. Under normal conditions, the body eliminates reverse-T3 rapidly. > Other enzymes quickly convert reverse-T3 to T2 and T2 to T1, and the body > eliminates these molecules within roughly 24-hours. (The process of > deiodination in the body is a bit more complicated than I can explain in > this short summary.) The point is that the process of deiodination is > dynamic and constantly changing, depending on the body's needs. > > Under certain conditions, the conversion of T4 to T3 decreases, and more > reverse T3 is produced from T4. Three of these conditions are food > deprivation (as during fasting or starvation), illness (such as liver > disease), and stresses that increase the blood level of the stress hormone > called cortisol. We assume that reduced conversion of T4 to T3 under such > conditions slows metabolism and aids survival. > > Thus, during fasting, disease, or stress, the conversion of T4 to reverse-T3 > increases. At these times, conversion of T4 to T3 decreases about 50%, and > conversion of T4 to reverse-T3 increases about 50%. Under normal, > non-stressful conditions, different enzymes convert some T4 to T3 and some > to reverse-T3. The same is true during fasting, illness, or stress; only the > percentages change--less T4 is converted to T3 and more is converted to > reverse-T3. > > The reduced T3 level that occurs during illness, fasting, or stress slows > the metabolism of many tissues. Because of the slowed metabolism, the body > does not eliminate reverse-T3 as rapidly as usual. The slowed elimination > from the body allows the reverse-T3 level in the blood to increase > considerably. > > In addition, during stressful experiences such as surgery and combat, the > amount of the stress hormone cortisol increases. The increase inhibits > conversion of T4 to T3; conversion of T4 to reverse-T3 increases. The same > inhibition occurs when a patient has Cushing's syndrome, a disease in which > the adrenal glands produce too much cortisol. Inhibition also occurs when a > patient begins taking cortisol as a medication such as prednisone. However, > whether the increased circulating cortisol occurs from stress, Cushing's > syndrome, or taking prednisone, the inhibition of T4 to T3 conversion is > temporary. It seldom lasts for more than one-to-three weeks, even if the > circulating cortisol level continues to be high. Studies have documented > that the inhibition is temporary. > > A popular belief nowadays (proposed by Dr. Dennis ) has not been proven > to be true, and much scientific evidence tips the scales in the " false " > direction with regard to this idea. The belief is that the process involving > impaired T4 to T3 conversion--with increases in reverse-T3--becomes stuck. The > " stuck " conversion is supposed to cause chronic low T3 levels and chronically > slowed metabolism. Some have speculated that the elevated reverse-T3 is the > culprit, continually blocking the conversion of T4 to T3 as a competitive > substrate for the 5’-deiodinase enzyme. However, this belief is contradicted > by studies of the dynamics of T4 to T3 conversion and T4 to reverse-T3 > conversion. Laboratory studies have shown that when factors such as increased > cortisol levels cause a decrease in T4 to T3 conversion and an increase in T4 > to reverse-T3 conversion, the shift in the percentages of T3 and reverse-T3 > produced is only temporary. > > Quote Link to comment Share on other sites More sharing options...
Guest guest Posted March 8, 2005 Report Share Posted March 8, 2005 what is the difference in 's T3 and just ordering T3 ? SandyE~Houston Re: *Reverse T3-OM This explains SOOOooo much. I have been under herrendous stress from mercury illness and some other things to boot. My question is, under the circumstances, I do not see a reason to take T4 at all. It seems to me that taking T3 only would be a better approach for me. I looked at the site for WILSON'S T3 and it makes sense for everything except that I can not afford to try it. ~Inga on 2/20/05 4:14 PM, *~ OM ~* at OM@... wrote: > > > > MORE THYROID INFORMATION > > http://drguberman.com/news.cfm?date_range=8/01/04 > > Armour and Thyrolar both contain 38 mcg of T4 and 9 mcg of T3. This is 4 > parts T4 to 1 part T3 (the exact ratio is 4.22 to 1). Some endocrinologists > now advocate the use of products containing both T4 and T3, but they > recommend a higher T4 to T3 ratio. They prefer a ratio 10 parts T4 to 1 part > T3. The lower T3 content of such products renders them far less effective > than Armour and Thyrolar. In our clinical experience, the treatment outcome > is inferior for patients who use products with the lower T3 content. The > inferior treatment outcome is supported by two recent studies conducted by > endocrinologists.[1][2] The studies showed that patients who added only a > small amount of T3 to their T4 continued to suffer from symptoms, just as > did patients who used T4 alone. The ratios of T4 to T3 the patients used > varied, but most used a higher T4 to T3 ration than in Armour and Thyrolar. > Of course, the endocrinologists restricted the patients' dosages according > to their TSH and thyroid hormone levels, and this almost guaranteed that the > patients took too little thyroid hormone and continued to suffer from > hypothyroid symptoms. If a new dose of Armour contains too little T4 and T3 > to benefit you, you'll have to go through another evaluation period. And > you'll have to do this again and again until you find what I call your > therapeutic window " -a small dosage range that optimally benefits you without > overstimulating you. That optimal dosage range is highly individual, but > historically, the typical patient's therapeutic window has been somewhere > between 120 to 240 mg (2 to 4 grains). There's no way to accurately predict > what your therapeutic window is. Until you find it, you may not improve much > from the Armour. But once you do, you're likely to feel that the wait was > well worth it. > > The thyroid gland secretes mostly T4 and very little T3. Most of the T3 that > drives cell metabolism is produced by action of the enzyme named 5 > -deiodinase, which converts T4 to T3. (We pronounce the " 5'- " as " five-prime > " ) Without this conversion of T4 to T3, cells have too little T3 to maintain > normal metabolism; metabolism then slows down. T3, therefore, is the > metabolically active thyroid hormone. For the most part, T4 is metabolically > inactive. T4 " drives " metabolism only after the deiodinase enzyme converts > it to T3. > > Another enzyme called 5-deiodinase continually converts some T4 to > reverse-T3. Reverse-T3 does not stimulate metabolism. It is produced as a > way to help clear some T4 from the body. > > Under normal conditions, cells continually convert about 40% of T4 to T3. > They convert about 60% of T4 to reverse-T3. Hour-by-hour, conversion of T4 > continues with slight shifts in the percentage of T4 converted to T3 and > reverse-T3. Under normal conditions, the body eliminates reverse-T3 rapidly. > Other enzymes quickly convert reverse-T3 to T2 and T2 to T1, and the body > eliminates these molecules within roughly 24-hours. (The process of > deiodination in the body is a bit more complicated than I can explain in > this short summary.) The point is that the process of deiodination is > dynamic and constantly changing, depending on the body's needs. > > Under certain conditions, the conversion of T4 to T3 decreases, and more > reverse T3 is produced from T4. Three of these conditions are food > deprivation (as during fasting or starvation), illness (such as liver > disease), and stresses that increase the blood level of the stress hormone > called cortisol. We assume that reduced conversion of T4 to T3 under such > conditions slows metabolism and aids survival. > > Thus, during fasting, disease, or stress, the conversion of T4 to reverse-T3 > increases. At these times, conversion of T4 to T3 decreases about 50%, and > conversion of T4 to reverse-T3 increases about 50%. Under normal, > non-stressful conditions, different enzymes convert some T4 to T3 and some > to reverse-T3. The same is true during fasting, illness, or stress; only the > percentages change--less T4 is converted to T3 and more is converted to > reverse-T3. > > The reduced T3 level that occurs during illness, fasting, or stress slows > the metabolism of many tissues. Because of the slowed metabolism, the body > does not eliminate reverse-T3 as rapidly as usual. The slowed elimination > from the body allows the reverse-T3 level in the blood to increase > considerably. > > In addition, during stressful experiences such as surgery and combat, the > amount of the stress hormone cortisol increases. The increase inhibits > conversion of T4 to T3; conversion of T4 to reverse-T3 increases. The same > inhibition occurs when a patient has Cushing's syndrome, a disease in which > the adrenal glands produce too much cortisol. Inhibition also occurs when a > patient begins taking cortisol as a medication such as prednisone. However, > whether the increased circulating cortisol occurs from stress, Cushing's > syndrome, or taking prednisone, the inhibition of T4 to T3 conversion is > temporary. It seldom lasts for more than one-to-three weeks, even if the > circulating cortisol level continues to be high. Studies have documented > that the inhibition is temporary. > > A popular belief nowadays (proposed by Dr. Dennis ) has not been proven > to be true, and much scientific evidence tips the scales in the " false " > direction with regard to this idea. The belief is that the process involving > impaired T4 to T3 conversion--with increases in reverse-T3--becomes stuck. The > " stuck " conversion is supposed to cause chronic low T3 levels and chronically > slowed metabolism. Some have speculated that the elevated reverse-T3 is the > culprit, continually blocking the conversion of T4 to T3 as a competitive > substrate for the 5'-deiodinase enzyme. However, this belief is contradicted > by studies of the dynamics of T4 to T3 conversion and T4 to reverse-T3 > conversion. Laboratory studies have shown that when factors such as increased > cortisol levels cause a decrease in T4 to T3 conversion and an increase in T4 > to reverse-T3 conversion, the shift in the percentages of T3 and reverse-T3 > produced is only temporary. > > Quote Link to comment Share on other sites More sharing options...
Guest guest Posted March 8, 2005 Report Share Posted March 8, 2005 what is the difference in 's T3 and just ordering T3 ? SandyE~Houston Re: *Reverse T3-OM This explains SOOOooo much. I have been under herrendous stress from mercury illness and some other things to boot. My question is, under the circumstances, I do not see a reason to take T4 at all. It seems to me that taking T3 only would be a better approach for me. I looked at the site for WILSON'S T3 and it makes sense for everything except that I can not afford to try it. ~Inga on 2/20/05 4:14 PM, *~ OM ~* at OM@... wrote: > > > > MORE THYROID INFORMATION > > http://drguberman.com/news.cfm?date_range=8/01/04 > > Armour and Thyrolar both contain 38 mcg of T4 and 9 mcg of T3. This is 4 > parts T4 to 1 part T3 (the exact ratio is 4.22 to 1). Some endocrinologists > now advocate the use of products containing both T4 and T3, but they > recommend a higher T4 to T3 ratio. They prefer a ratio 10 parts T4 to 1 part > T3. The lower T3 content of such products renders them far less effective > than Armour and Thyrolar. In our clinical experience, the treatment outcome > is inferior for patients who use products with the lower T3 content. The > inferior treatment outcome is supported by two recent studies conducted by > endocrinologists.[1][2] The studies showed that patients who added only a > small amount of T3 to their T4 continued to suffer from symptoms, just as > did patients who used T4 alone. The ratios of T4 to T3 the patients used > varied, but most used a higher T4 to T3 ration than in Armour and Thyrolar. > Of course, the endocrinologists restricted the patients' dosages according > to their TSH and thyroid hormone levels, and this almost guaranteed that the > patients took too little thyroid hormone and continued to suffer from > hypothyroid symptoms. If a new dose of Armour contains too little T4 and T3 > to benefit you, you'll have to go through another evaluation period. And > you'll have to do this again and again until you find what I call your > therapeutic window " -a small dosage range that optimally benefits you without > overstimulating you. That optimal dosage range is highly individual, but > historically, the typical patient's therapeutic window has been somewhere > between 120 to 240 mg (2 to 4 grains). There's no way to accurately predict > what your therapeutic window is. Until you find it, you may not improve much > from the Armour. But once you do, you're likely to feel that the wait was > well worth it. > > The thyroid gland secretes mostly T4 and very little T3. Most of the T3 that > drives cell metabolism is produced by action of the enzyme named 5 > -deiodinase, which converts T4 to T3. (We pronounce the " 5'- " as " five-prime > " ) Without this conversion of T4 to T3, cells have too little T3 to maintain > normal metabolism; metabolism then slows down. T3, therefore, is the > metabolically active thyroid hormone. For the most part, T4 is metabolically > inactive. T4 " drives " metabolism only after the deiodinase enzyme converts > it to T3. > > Another enzyme called 5-deiodinase continually converts some T4 to > reverse-T3. Reverse-T3 does not stimulate metabolism. It is produced as a > way to help clear some T4 from the body. > > Under normal conditions, cells continually convert about 40% of T4 to T3. > They convert about 60% of T4 to reverse-T3. Hour-by-hour, conversion of T4 > continues with slight shifts in the percentage of T4 converted to T3 and > reverse-T3. Under normal conditions, the body eliminates reverse-T3 rapidly. > Other enzymes quickly convert reverse-T3 to T2 and T2 to T1, and the body > eliminates these molecules within roughly 24-hours. (The process of > deiodination in the body is a bit more complicated than I can explain in > this short summary.) The point is that the process of deiodination is > dynamic and constantly changing, depending on the body's needs. > > Under certain conditions, the conversion of T4 to T3 decreases, and more > reverse T3 is produced from T4. Three of these conditions are food > deprivation (as during fasting or starvation), illness (such as liver > disease), and stresses that increase the blood level of the stress hormone > called cortisol. We assume that reduced conversion of T4 to T3 under such > conditions slows metabolism and aids survival. > > Thus, during fasting, disease, or stress, the conversion of T4 to reverse-T3 > increases. At these times, conversion of T4 to T3 decreases about 50%, and > conversion of T4 to reverse-T3 increases about 50%. Under normal, > non-stressful conditions, different enzymes convert some T4 to T3 and some > to reverse-T3. The same is true during fasting, illness, or stress; only the > percentages change--less T4 is converted to T3 and more is converted to > reverse-T3. > > The reduced T3 level that occurs during illness, fasting, or stress slows > the metabolism of many tissues. Because of the slowed metabolism, the body > does not eliminate reverse-T3 as rapidly as usual. The slowed elimination > from the body allows the reverse-T3 level in the blood to increase > considerably. > > In addition, during stressful experiences such as surgery and combat, the > amount of the stress hormone cortisol increases. The increase inhibits > conversion of T4 to T3; conversion of T4 to reverse-T3 increases. The same > inhibition occurs when a patient has Cushing's syndrome, a disease in which > the adrenal glands produce too much cortisol. Inhibition also occurs when a > patient begins taking cortisol as a medication such as prednisone. However, > whether the increased circulating cortisol occurs from stress, Cushing's > syndrome, or taking prednisone, the inhibition of T4 to T3 conversion is > temporary. It seldom lasts for more than one-to-three weeks, even if the > circulating cortisol level continues to be high. Studies have documented > that the inhibition is temporary. > > A popular belief nowadays (proposed by Dr. Dennis ) has not been proven > to be true, and much scientific evidence tips the scales in the " false " > direction with regard to this idea. The belief is that the process involving > impaired T4 to T3 conversion--with increases in reverse-T3--becomes stuck. The > " stuck " conversion is supposed to cause chronic low T3 levels and chronically > slowed metabolism. Some have speculated that the elevated reverse-T3 is the > culprit, continually blocking the conversion of T4 to T3 as a competitive > substrate for the 5'-deiodinase enzyme. However, this belief is contradicted > by studies of the dynamics of T4 to T3 conversion and T4 to reverse-T3 > conversion. Laboratory studies have shown that when factors such as increased > cortisol levels cause a decrease in T4 to T3 conversion and an increase in T4 > to reverse-T3 conversion, the shift in the percentages of T3 and reverse-T3 > produced is only temporary. > > Quote Link to comment Share on other sites More sharing options...
Guest guest Posted March 8, 2005 Report Share Posted March 8, 2005 what is the difference in 's T3 and just ordering T3 ? SandyE~Houston Re: *Reverse T3-OM This explains SOOOooo much. I have been under herrendous stress from mercury illness and some other things to boot. My question is, under the circumstances, I do not see a reason to take T4 at all. It seems to me that taking T3 only would be a better approach for me. I looked at the site for WILSON'S T3 and it makes sense for everything except that I can not afford to try it. ~Inga on 2/20/05 4:14 PM, *~ OM ~* at OM@... wrote: > > > > MORE THYROID INFORMATION > > http://drguberman.com/news.cfm?date_range=8/01/04 > > Armour and Thyrolar both contain 38 mcg of T4 and 9 mcg of T3. This is 4 > parts T4 to 1 part T3 (the exact ratio is 4.22 to 1). Some endocrinologists > now advocate the use of products containing both T4 and T3, but they > recommend a higher T4 to T3 ratio. They prefer a ratio 10 parts T4 to 1 part > T3. The lower T3 content of such products renders them far less effective > than Armour and Thyrolar. In our clinical experience, the treatment outcome > is inferior for patients who use products with the lower T3 content. The > inferior treatment outcome is supported by two recent studies conducted by > endocrinologists.[1][2] The studies showed that patients who added only a > small amount of T3 to their T4 continued to suffer from symptoms, just as > did patients who used T4 alone. The ratios of T4 to T3 the patients used > varied, but most used a higher T4 to T3 ration than in Armour and Thyrolar. > Of course, the endocrinologists restricted the patients' dosages according > to their TSH and thyroid hormone levels, and this almost guaranteed that the > patients took too little thyroid hormone and continued to suffer from > hypothyroid symptoms. If a new dose of Armour contains too little T4 and T3 > to benefit you, you'll have to go through another evaluation period. And > you'll have to do this again and again until you find what I call your > therapeutic window " -a small dosage range that optimally benefits you without > overstimulating you. That optimal dosage range is highly individual, but > historically, the typical patient's therapeutic window has been somewhere > between 120 to 240 mg (2 to 4 grains). There's no way to accurately predict > what your therapeutic window is. Until you find it, you may not improve much > from the Armour. But once you do, you're likely to feel that the wait was > well worth it. > > The thyroid gland secretes mostly T4 and very little T3. Most of the T3 that > drives cell metabolism is produced by action of the enzyme named 5 > -deiodinase, which converts T4 to T3. (We pronounce the " 5'- " as " five-prime > " ) Without this conversion of T4 to T3, cells have too little T3 to maintain > normal metabolism; metabolism then slows down. T3, therefore, is the > metabolically active thyroid hormone. For the most part, T4 is metabolically > inactive. T4 " drives " metabolism only after the deiodinase enzyme converts > it to T3. > > Another enzyme called 5-deiodinase continually converts some T4 to > reverse-T3. Reverse-T3 does not stimulate metabolism. It is produced as a > way to help clear some T4 from the body. > > Under normal conditions, cells continually convert about 40% of T4 to T3. > They convert about 60% of T4 to reverse-T3. Hour-by-hour, conversion of T4 > continues with slight shifts in the percentage of T4 converted to T3 and > reverse-T3. Under normal conditions, the body eliminates reverse-T3 rapidly. > Other enzymes quickly convert reverse-T3 to T2 and T2 to T1, and the body > eliminates these molecules within roughly 24-hours. (The process of > deiodination in the body is a bit more complicated than I can explain in > this short summary.) The point is that the process of deiodination is > dynamic and constantly changing, depending on the body's needs. > > Under certain conditions, the conversion of T4 to T3 decreases, and more > reverse T3 is produced from T4. Three of these conditions are food > deprivation (as during fasting or starvation), illness (such as liver > disease), and stresses that increase the blood level of the stress hormone > called cortisol. We assume that reduced conversion of T4 to T3 under such > conditions slows metabolism and aids survival. > > Thus, during fasting, disease, or stress, the conversion of T4 to reverse-T3 > increases. At these times, conversion of T4 to T3 decreases about 50%, and > conversion of T4 to reverse-T3 increases about 50%. Under normal, > non-stressful conditions, different enzymes convert some T4 to T3 and some > to reverse-T3. The same is true during fasting, illness, or stress; only the > percentages change--less T4 is converted to T3 and more is converted to > reverse-T3. > > The reduced T3 level that occurs during illness, fasting, or stress slows > the metabolism of many tissues. Because of the slowed metabolism, the body > does not eliminate reverse-T3 as rapidly as usual. The slowed elimination > from the body allows the reverse-T3 level in the blood to increase > considerably. > > In addition, during stressful experiences such as surgery and combat, the > amount of the stress hormone cortisol increases. The increase inhibits > conversion of T4 to T3; conversion of T4 to reverse-T3 increases. The same > inhibition occurs when a patient has Cushing's syndrome, a disease in which > the adrenal glands produce too much cortisol. Inhibition also occurs when a > patient begins taking cortisol as a medication such as prednisone. However, > whether the increased circulating cortisol occurs from stress, Cushing's > syndrome, or taking prednisone, the inhibition of T4 to T3 conversion is > temporary. It seldom lasts for more than one-to-three weeks, even if the > circulating cortisol level continues to be high. Studies have documented > that the inhibition is temporary. > > A popular belief nowadays (proposed by Dr. Dennis ) has not been proven > to be true, and much scientific evidence tips the scales in the " false " > direction with regard to this idea. The belief is that the process involving > impaired T4 to T3 conversion--with increases in reverse-T3--becomes stuck. The > " stuck " conversion is supposed to cause chronic low T3 levels and chronically > slowed metabolism. Some have speculated that the elevated reverse-T3 is the > culprit, continually blocking the conversion of T4 to T3 as a competitive > substrate for the 5'-deiodinase enzyme. However, this belief is contradicted > by studies of the dynamics of T4 to T3 conversion and T4 to reverse-T3 > conversion. Laboratory studies have shown that when factors such as increased > cortisol levels cause a decrease in T4 to T3 conversion and an increase in T4 > to reverse-T3 conversion, the shift in the percentages of T3 and reverse-T3 > produced is only temporary. > > Quote Link to comment Share on other sites More sharing options...
Guest guest Posted March 8, 2005 Report Share Posted March 8, 2005 on 3/8/05 9:12 PM, sandy at starz@... wrote: > > what is the difference in 's T3 and just ordering T3 ? >>>I don't know - Paying a bunch to a doctor??? No seriously, one difference is that they have a compounding pharmacy make you a timed-release formula so you only have to take twice a day, I believe. Then there is also some kind of adrenal protocl they have. I do not know much about it yet. It may or may not be covered in the free online book. http://www.wilsonsthyroidsyndrome.com/eManual/Introduction/ >>>I think I am gong to try and do it on my own. Now, to decide between CYTOMEL and THYTROPHIN...Hmmmm..... >>>Val, do you have sources for both of those...I have something, I think, but woud like to see what you have. ~Inga > > SandyE~Houston > Re: *Reverse T3-OM > > > This explains SOOOooo much. I have been under herrendous stress from mercury > illness and some other things to boot. > > My question is, under the circumstances, I do not see a reason to take T4 at > all. It seems to me that taking T3 only would be a better approach for me. I > looked at the site for WILSON'S T3 and it makes sense for everything except > that I can not afford to try it. > ~Inga > > > on 2/20/05 4:14 PM, *~ OM ~* at OM@... wrote: > >> >> >> >> MORE THYROID INFORMATION >> >> http://drguberman.com/news.cfm?date_range=8/01/04 >> >> Armour and Thyrolar both contain 38 mcg of T4 and 9 mcg of T3. This is 4 >> parts T4 to 1 part T3 (the exact ratio is 4.22 to 1). Some endocrinologists >> now advocate the use of products containing both T4 and T3, but they >> recommend a higher T4 to T3 ratio. They prefer a ratio 10 parts T4 to 1 part >> T3. The lower T3 content of such products renders them far less effective >> than Armour and Thyrolar. In our clinical experience, the treatment outcome >> is inferior for patients who use products with the lower T3 content. The >> inferior treatment outcome is supported by two recent studies conducted by >> endocrinologists.[1][2] The studies showed that patients who added only a >> small amount of T3 to their T4 continued to suffer from symptoms, just as >> did patients who used T4 alone. The ratios of T4 to T3 the patients used >> varied, but most used a higher T4 to T3 ration than in Armour and Thyrolar. >> Of course, the endocrinologists restricted the patients' dosages according >> to their TSH and thyroid hormone levels, and this almost guaranteed that the >> patients took too little thyroid hormone and continued to suffer from >> hypothyroid symptoms. If a new dose of Armour contains too little T4 and T3 >> to benefit you, you'll have to go through another evaluation period. And >> you'll have to do this again and again until you find what I call your >> therapeutic window " -a small dosage range that optimally benefits you without >> overstimulating you. That optimal dosage range is highly individual, but >> historically, the typical patient's therapeutic window has been somewhere >> between 120 to 240 mg (2 to 4 grains). There's no way to accurately predict >> what your therapeutic window is. Until you find it, you may not improve much >> from the Armour. But once you do, you're likely to feel that the wait was >> well worth it. >> >> The thyroid gland secretes mostly T4 and very little T3. Most of the T3 that >> drives cell metabolism is produced by action of the enzyme named 5 >> -deiodinase, which converts T4 to T3. (We pronounce the " 5'- " as " five-prime >> " ) Without this conversion of T4 to T3, cells have too little T3 to maintain >> normal metabolism; metabolism then slows down. T3, therefore, is the >> metabolically active thyroid hormone. For the most part, T4 is metabolically >> inactive. T4 " drives " metabolism only after the deiodinase enzyme converts >> it to T3. >> >> Another enzyme called 5-deiodinase continually converts some T4 to >> reverse-T3. Reverse-T3 does not stimulate metabolism. It is produced as a >> way to help clear some T4 from the body. >> >> Under normal conditions, cells continually convert about 40% of T4 to T3. >> They convert about 60% of T4 to reverse-T3. Hour-by-hour, conversion of T4 >> continues with slight shifts in the percentage of T4 converted to T3 and >> reverse-T3. Under normal conditions, the body eliminates reverse-T3 rapidly. >> Other enzymes quickly convert reverse-T3 to T2 and T2 to T1, and the body >> eliminates these molecules within roughly 24-hours. (The process of >> deiodination in the body is a bit more complicated than I can explain in >> this short summary.) The point is that the process of deiodination is >> dynamic and constantly changing, depending on the body's needs. >> >> Under certain conditions, the conversion of T4 to T3 decreases, and more >> reverse T3 is produced from T4. Three of these conditions are food >> deprivation (as during fasting or starvation), illness (such as liver >> disease), and stresses that increase the blood level of the stress hormone >> called cortisol. We assume that reduced conversion of T4 to T3 under such >> conditions slows metabolism and aids survival. >> >> Thus, during fasting, disease, or stress, the conversion of T4 to reverse-T3 >> increases. At these times, conversion of T4 to T3 decreases about 50%, and >> conversion of T4 to reverse-T3 increases about 50%. Under normal, >> non-stressful conditions, different enzymes convert some T4 to T3 and some >> to reverse-T3. The same is true during fasting, illness, or stress; only the >> percentages change--less T4 is converted to T3 and more is converted to >> reverse-T3. >> >> The reduced T3 level that occurs during illness, fasting, or stress slows >> the metabolism of many tissues. Because of the slowed metabolism, the body >> does not eliminate reverse-T3 as rapidly as usual. The slowed elimination >> from the body allows the reverse-T3 level in the blood to increase >> considerably. >> >> In addition, during stressful experiences such as surgery and combat, the >> amount of the stress hormone cortisol increases. The increase inhibits >> conversion of T4 to T3; conversion of T4 to reverse-T3 increases. The same >> inhibition occurs when a patient has Cushing's syndrome, a disease in which >> the adrenal glands produce too much cortisol. Inhibition also occurs when a >> patient begins taking cortisol as a medication such as prednisone. However, >> whether the increased circulating cortisol occurs from stress, Cushing's >> syndrome, or taking prednisone, the inhibition of T4 to T3 conversion is >> temporary. It seldom lasts for more than one-to-three weeks, even if the >> circulating cortisol level continues to be high. Studies have documented >> that the inhibition is temporary. >> >> A popular belief nowadays (proposed by Dr. Dennis ) has not been proven >> to be true, and much scientific evidence tips the scales in the " false " >> direction with regard to this idea. The belief is that the process involving >> impaired T4 to T3 conversion--with increases in reverse-T3--becomes stuck. >> The >> " stuck " conversion is supposed to cause chronic low T3 levels and chronically >> slowed metabolism. Some have speculated that the elevated reverse-T3 is the >> culprit, continually blocking the conversion of T4 to T3 as a competitive >> substrate for the 5'-deiodinase enzyme. However, this belief is contradicted >> by studies of the dynamics of T4 to T3 conversion and T4 to reverse-T3 >> conversion. Laboratory studies have shown that when factors such as increased >> cortisol levels cause a decrease in T4 to T3 conversion and an increase in T4 >> to reverse-T3 conversion, the shift in the percentages of T3 and reverse-T3 >> produced is only temporary. >> >> Quote Link to comment Share on other sites More sharing options...
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