Guest guest Posted July 17, 2004 Report Share Posted July 17, 2004 My methotrexate worked pretty quick. And yes, it did upset my stomach for about a month and then it was okay. Once in a while it will still bother me, but only if I don't eat anything after I take it. Is your stomach bothering you 24/7 or just after taking it? Quote Link to comment Share on other sites More sharing options...
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