Guest guest Posted January 29, 2009 Report Share Posted January 29, 2009 I just responded to the small duct PSC question and posted a link to a pericholangitis article. Here is what they said were the causes of pericholangitis (small duct PSC) Causes * The etiology of pericholangitis is unknown. * Proposed theories include the following: o Autoimmunity o Portal bacteremia o Absorption of colonic toxins o Ischemic injury to the biliary tree o Viral infections o Toxic bile acids in a genetically predisposed individual Aren't these the same causes for classic/large duct PSC ? My son has ALL of the above known factors that could have caused his PSC. We know about his risks because of his short bowel syndrome and what it can do to the liver/biliary system. I guess that is an 'advantage' in some ways to know what is causing problems..but not in being able to treat the problems in his case. The above causes seem to point towards hope for vancomycin trials to be successful in treating PSC. Lori lucky mom blessed with triplets www.caringbridge.org/visit/bradenwild Quote Link to comment Share on other sites More sharing options...
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