Guest guest Posted October 13, 2002 Report Share Posted October 13, 2002 Early airway infection, inflammation, and lung function in cystic fibrosis G M Nixon1, D S Armstrong1, R Carzino1, J B Carlin2, A Olinsky1, C F on1 and K Grimwood3 1 Department of Respiratory Medicine, Royal Children’s Hospital, Melbourne, Australia 2 Clinical Epidemiology and Biostatistics Unit, Murdoch Children’s Research Institute, Melbourne, Australia 3 Wellington School of Medicine and Health Sciences, University of Otago, Wellington, New Zealand Correspondence to: Dr G Nixon, Division of Respiratory Medicine, Montreal Children’s Hospital, 2300 Tupper St, Montreal H3H 1P3, Canada; : To determine the relation between lower airway infection and inflammation, respiratory symptoms, and lung function in infants and young children with cystic fibrosis (CF). Methods: A prospective study of children with CF aged younger than 3 years, diagnosed by a newborn screening programme. All were clinically stable and had testing as outpatients. Subjects underwent bronchial lavage (BL) and lung function testing by the raised volume rapid thoracoabdominal compression technique under general anaesthesia. BL fluid was cultured and analysed for neutrophil count, interleukin 8, and neutrophil elastase. Lung function was assessed by forced expiratory volume in 0.5, 0.75, and 1 second. Results: Thirty six children with CF were tested on 54 occasions. Lower airway infection shown by BL was associated with a 10% reduction in FEV0.5 compared with subjects without infection. No relation was identified between airway inflammation and lung function. Daily moist cough within the week before testing was reported on 20/54 occasions, but in only seven (35%) was infection detected. Independent of either infection status or airway inflammation, those with daily cough had lower lung function than those without respiratory symptoms at the time of BL (mean adjusted FEV0.5 195 ml and 236 ml respectively). Conclusions: In young children with CF, both respiratory symptoms and airway infection have independent, additive effects on lung function, unrelated to airway inflammation. Further studies are needed to understand the mechanisms of airway obstruction in these young patients. Keywords: respiratory function test; cystic fibrosis; infection; inflammationAbbreviations: BL, bronchial lavage; CBA, chocolate bacitracin agar; CF, cystic fibrosis; CFU, colony forming unit; FEV, forced expiratory volume; GEE, generalised estimating equation; IL, interleukin Becki YOUR FAVORITE LilGooberGirl YOUNGLUNG EMAIL SUPPORT LIST www.topica.com/lists/younglung Pediatric Interstitial Lung Disease Society http://groups.yahoo.com/group/InterstitialLung_Kids/ Quote Link to comment Share on other sites More sharing options...
Guest guest Posted October 13, 2002 Report Share Posted October 13, 2002 HI! CF AWARENESS WEEK is October 13 (TODAY!) through the 19th, 2002 Why does it always seem to change? Because of those silly Aussies (just kidding!) Seriously, Australia has had a Red Ribbon Day, which is their CF Awareness Day, on October 15th. In the hope that someday we can all celebrate an INTERNATIONAL C F Awareness Week, the U.S. grassroots group chose the week that includes this day as our awareness week. Lenora http://www.cfawareness.org >Hey, how are you ? I know you keep up with all the posts please tell me >exactly what days in Oct. are Cf awareness Week ? I can't find it in the >archives.Thanks a bunch ! > >x > > > Quote Link to comment Share on other sites More sharing options...
Guest guest Posted October 13, 2002 Report Share Posted October 13, 2002 HI! CF AWARENESS WEEK is October 13 (TODAY!) through the 19th, 2002 Why does it always seem to change? Because of those silly Aussies (just kidding!) Seriously, Australia has had a Red Ribbon Day, which is their CF Awareness Day, on October 15th. In the hope that someday we can all celebrate an INTERNATIONAL C F Awareness Week, the U.S. grassroots group chose the week that includes this day as our awareness week. Lenora http://www.cfawareness.org >Hey, how are you ? I know you keep up with all the posts please tell me >exactly what days in Oct. are Cf awareness Week ? I can't find it in the >archives.Thanks a bunch ! > >x > > > Quote Link to comment Share on other sites More sharing options...
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