Interesting Cystic Fibrosis Articles

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Acute renal failure in cystic fibrosis: Association with inhaled

tobramycin therapy -- Pediatric Pulmonology

http://www.pulmonologylinx.com/thearts.cfm?artid=425398&specid=14

We describe a 20-year-old patient with cystic fibrosis who developed

acute nonoliguric renal failure associated with inhaled tobramycin.

Clinical evaluation and renal biopsy findings were consistent with

aminoglycoside-induced changes. Renal failure due to inhaled

aminoglycosides has not been previously reported. The incidence may

rise, however, with the increased use of this treatment modality.

Measurable tobramycin levels due to inhalational therapy with

conventional dosing in the reported patient indicate that the drug can

be systemically absorbed, and renal tubular toxicity may occur ...

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Case Report: Adrenal insufficiency and

testicular failure secondary to megestrol acetate therapy in a patient

with cystic fibrosis -- Pediatric Pulmonology

http://www.pulmonologylinx.com/thearts.cfm?artid=425400&specid=14

We present a case report of adrenal insufficiency and testicular failure

in an adult cystic fibrosis (CF) patient due to megestrol acetate

therapy. This is followed by a review of the literature on the use of

megestrol acetate in the treatment of weight loss in CF, AIDS, and

cancer, with particular emphasis on the adverse effects that should be

looked for in CF patients...

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Reversal of digital clubbing after

lung transplantation in cystic fibrosis patients: A clue to the

pathogenesis of clubbing -- Pediatric Pulmonology

http://www.pulmonologylinx.com/thearts.cfm?artid=425399&specid=14

We conclude that digital clubbing is reversible in CF patients who

undergo lung transplantation. Regression was usually noted during the

first 3 months posttransplantation. This could be explained either by

adequate inactivation of a circulating clubbing-inducing molecule by the

normal transplanted lungs, or by removal of the diseased lungs in which

this presumably causative substance was produced...

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Two cases of immune haemolytic

anaemia, associated with anti-piperacillin, detected by the 'immune

complex' method -- Vox Sanguinis

http://www.pulmonologylinx.com/thearts.cfm?artid=429675&specid=14

Conclusions: We describe the third and fourth examples of immune

haemolytic anaemia caused by anti-piperacillin; one was associated with

fatal haemolytic anaemia. As piperacillin is commonly used in the

treatment of cystic fibrosis, anti-piperacillin should be considered

whenever patients with cystic fibrosis develop haemolytic anaemia and/or

positive DATs...

Becki

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