Guest guest Posted April 18, 2002 Report Share Posted April 18, 2002 > > > Incidently, not long after Dr. Nase published, the NRS funded > > > someone to research on Nitric Oxide. Does anyone know if his > book > > > brought on the idea? > > > > Patty, vascular research on nitric oxide is a hot topic, ever since > > it was identified as the endothelial relaxing factor in the early > > 1980s. In fact, the 1998 Nobel Prize went to the original > researchers > > for their discovery of nitric oxide. I don't know much about it, > but > > I understand it is of interest to many disorders; for example, I > > believe the pharmacology of Viagra involves nitric oxide, and it > has > > also been postulated in the mechanism of essential hypertension. > > > > I gather the theory regarding nitric oxide and rosacea involves an > > overproduction of NO/increased number or activity of NO > > receptors/decreased breakdown of NO/oversensitivity of vascular > > smooth muscles, etc. involving the vessels of the central face. Can > > someone enlighten me as to the precise theory, and where I might > > locate support for the theory in the medical literature? > > > > Thanks, > > > > Marjorie > > > > Marjorie Lazoff, MD Quote Link to comment Share on other sites More sharing options...
Guest guest Posted April 19, 2002 Report Share Posted April 19, 2002 Marjorie, That's not the article I was referring to. (I'm sorry. I should have searched for it and provided you the link myself.) It's an abstract by Ethan Lerner, MD, regarding his hypothesis on NO and rosacea. Here's a link to it if you're interested in it. http://groups.yahoo.com/group/rosacea-support/message/24047 Take care, Matija > > > > Incidently, not long after Dr. Nase published, the NRS funded > > > > someone to research on Nitric Oxide. Does anyone know if his > > book > > > > brought on the idea? > > > > > > Patty, vascular research on nitric oxide is a hot topic, ever > since > > > it was identified as the endothelial relaxing factor in the early > > > 1980s. In fact, the 1998 Nobel Prize went to the original > > researchers > > > for their discovery of nitric oxide. I don't know much about it, > > but > > > I understand it is of interest to many disorders; for example, I > > > believe the pharmacology of Viagra involves nitric oxide, and it > > has > > > also been postulated in the mechanism of essential hypertension. > > > > > > I gather the theory regarding nitric oxide and rosacea involves > an > > > overproduction of NO/increased number or activity of NO > > > receptors/decreased breakdown of NO/oversensitivity of vascular > > > smooth muscles, etc. involving the vessels of the central face. > Can > > > someone enlighten me as to the precise theory, and where I might > > > locate support for the theory in the medical literature? > > > > > > Thanks, > > > > > > Marjorie > > > > > > Marjorie Lazoff, MD Quote Link to comment Share on other sites More sharing options...
Guest guest Posted April 19, 2002 Report Share Posted April 19, 2002 > > > > > Incidently, not long after Dr. Nase published, the NRS funded > > > > > someone to research on Nitric Oxide. Does anyone know if his > > > book > > > > > brought on the idea? > > > > > > > > Patty, vascular research on nitric oxide is a hot topic, ever > > since > > > > it was identified as the endothelial relaxing factor in the > early > > > > 1980s. In fact, the 1998 Nobel Prize went to the original > > > researchers > > > > for their discovery of nitric oxide. I don't know much about > it, > > > but > > > > I understand it is of interest to many disorders; for example, > I > > > > believe the pharmacology of Viagra involves nitric oxide, and > it > > > has > > > > also been postulated in the mechanism of essential > hypertension. > > > > > > > > I gather the theory regarding nitric oxide and rosacea involves > > an > > > > overproduction of NO/increased number or activity of NO > > > > receptors/decreased breakdown of NO/oversensitivity of vascular > > > > smooth muscles, etc. involving the vessels of the central face. > > Can > > > > someone enlighten me as to the precise theory, and where I > might > > > > locate support for the theory in the medical literature? > > > > > > > > Thanks, > > > > > > > > Marjorie > > > > > > > > Marjorie Lazoff, MD Quote Link to comment Share on other sites More sharing options...
Guest guest Posted April 19, 2002 Report Share Posted April 19, 2002 I thought you might find Dr. Lerner's abstract more helpful! I always copy an article into a message because you never know when a web address will change. I have to add that I remember from our group posting about a doctor in the UK who was conducting an experiment with rosaceans applying a topical NO inhibitor to their faces. I don't think that the results were that promising. Also, did Dr. Nase conduct his L-Name experiments on himself alone or did he also try it with other rosaceans? I was meaning to ask him when he came back to the group, whenever in the future that would be. If he applied the NO inhibitor to his face and not to any other rosaceans, that wouldn't give precise results. Dr. Nase said he beat rosacea by photoderm sessions and ETS, so I don't know the level of flushing that he had at the time of his experiment. I thought that he had gone back to the pre-rosacea stage of this disease. If anyone knows anything else about this, please let us know. Thanks, Matija > > > > > > Incidently, not long after Dr. Nase published, the NRS > funded > > > > > > someone to research on Nitric Oxide. Does anyone know if > his > > > > book > > > > > > brought on the idea? > > > > > > > > > > Patty, vascular research on nitric oxide is a hot topic, ever > > > since > > > > > it was identified as the endothelial relaxing factor in the > > early > > > > > 1980s. In fact, the 1998 Nobel Prize went to the original > > > > researchers > > > > > for their discovery of nitric oxide. I don't know much about > > it, > > > > but > > > > > I understand it is of interest to many disorders; for > example, > > I > > > > > believe the pharmacology of Viagra involves nitric oxide, and > > it > > > > has > > > > > also been postulated in the mechanism of essential > > hypertension. > > > > > > > > > > I gather the theory regarding nitric oxide and rosacea > involves > > > an > > > > > overproduction of NO/increased number or activity of NO > > > > > receptors/decreased breakdown of NO/oversensitivity of > vascular > > > > > smooth muscles, etc. involving the vessels of the central > face. > > > Can > > > > > someone enlighten me as to the precise theory, and where I > > might > > > > > locate support for the theory in the medical literature? > > > > > > > > > > Thanks, > > > > > > > > > > Marjorie > > > > > > > > > > Marjorie Lazoff, MD Quote Link to comment Share on other sites More sharing options...
Guest guest Posted April 19, 2002 Report Share Posted April 19, 2002 I thought you might find Dr. Lerner's abstract more helpful! I always copy an article into a message because you never know when a web address will change. I have to add that I remember from our group posting about a doctor in the UK who was conducting an experiment with rosaceans applying a topical NO inhibitor to their faces. I don't think that the results were that promising. Also, did Dr. Nase conduct his L-Name experiments on himself alone or did he also try it with other rosaceans? I was meaning to ask him when he came back to the group, whenever in the future that would be. If he applied the NO inhibitor to his face and not to any other rosaceans, that wouldn't give precise results. Dr. Nase said he beat rosacea by photoderm sessions and ETS, so I don't know the level of flushing that he had at the time of his experiment. I thought that he had gone back to the pre-rosacea stage of this disease. If anyone knows anything else about this, please let us know. Thanks, Matija > > > > > > Incidently, not long after Dr. Nase published, the NRS > funded > > > > > > someone to research on Nitric Oxide. Does anyone know if > his > > > > book > > > > > > brought on the idea? > > > > > > > > > > Patty, vascular research on nitric oxide is a hot topic, ever > > > since > > > > > it was identified as the endothelial relaxing factor in the > > early > > > > > 1980s. In fact, the 1998 Nobel Prize went to the original > > > > researchers > > > > > for their discovery of nitric oxide. I don't know much about > > it, > > > > but > > > > > I understand it is of interest to many disorders; for > example, > > I > > > > > believe the pharmacology of Viagra involves nitric oxide, and > > it > > > > has > > > > > also been postulated in the mechanism of essential > > hypertension. > > > > > > > > > > I gather the theory regarding nitric oxide and rosacea > involves > > > an > > > > > overproduction of NO/increased number or activity of NO > > > > > receptors/decreased breakdown of NO/oversensitivity of > vascular > > > > > smooth muscles, etc. involving the vessels of the central > face. > > > Can > > > > > someone enlighten me as to the precise theory, and where I > > might > > > > > locate support for the theory in the medical literature? > > > > > > > > > > Thanks, > > > > > > > > > > Marjorie > > > > > > > > > > Marjorie Lazoff, MD Quote Link to comment Share on other sites More sharing options...
Guest guest Posted April 19, 2002 Report Share Posted April 19, 2002 I thought you might find Dr. Lerner's abstract more helpful! I always copy an article into a message because you never know when a web address will change. I have to add that I remember from our group posting about a doctor in the UK who was conducting an experiment with rosaceans applying a topical NO inhibitor to their faces. I don't think that the results were that promising. Also, did Dr. Nase conduct his L-Name experiments on himself alone or did he also try it with other rosaceans? I was meaning to ask him when he came back to the group, whenever in the future that would be. If he applied the NO inhibitor to his face and not to any other rosaceans, that wouldn't give precise results. Dr. Nase said he beat rosacea by photoderm sessions and ETS, so I don't know the level of flushing that he had at the time of his experiment. I thought that he had gone back to the pre-rosacea stage of this disease. If anyone knows anything else about this, please let us know. Thanks, Matija > > > > > > Incidently, not long after Dr. Nase published, the NRS > funded > > > > > > someone to research on Nitric Oxide. Does anyone know if > his > > > > book > > > > > > brought on the idea? > > > > > > > > > > Patty, vascular research on nitric oxide is a hot topic, ever > > > since > > > > > it was identified as the endothelial relaxing factor in the > > early > > > > > 1980s. In fact, the 1998 Nobel Prize went to the original > > > > researchers > > > > > for their discovery of nitric oxide. I don't know much about > > it, > > > > but > > > > > I understand it is of interest to many disorders; for > example, > > I > > > > > believe the pharmacology of Viagra involves nitric oxide, and > > it > > > > has > > > > > also been postulated in the mechanism of essential > > hypertension. > > > > > > > > > > I gather the theory regarding nitric oxide and rosacea > involves > > > an > > > > > overproduction of NO/increased number or activity of NO > > > > > receptors/decreased breakdown of NO/oversensitivity of > vascular > > > > > smooth muscles, etc. involving the vessels of the central > face. > > > Can > > > > > someone enlighten me as to the precise theory, and where I > > might > > > > > locate support for the theory in the medical literature? > > > > > > > > > > Thanks, > > > > > > > > > > Marjorie > > > > > > > > > > Marjorie Lazoff, MD Quote Link to comment Share on other sites More sharing options...
Guest guest Posted April 19, 2002 Report Share Posted April 19, 2002 Oops! I meant to say NO research specifically for cea, not just NO research in general. Sorry for any confusion. From what I remember reading, Dr. Nase says that NO is the final step in the vasodilation process in the blood vessels. I think he may have cited a study that showed more NO in rosaceans but I'll have to double check the book. Anyway, from what I remember his theory is that since we have more NO in our skin, we have an exaggerated vasodilation response when flushing or blushing from any and all triggers. He goes into much more detail than that, though. I can type it out and send to you all this weekend. I wish we all had that Dr. Nase's book! If NO inhibitors work it will especially exciting because it could wipe out all triggers. It would be a dream come true. Do a search on Ethan Lerner in the archives. There are a few more emails that may be of interest. Please let us know what Ethan Lerner says. How exciting!!!! Thanks! Patty > > > Incidently, not long after Dr. Nase published, the NRS funded > > someone to research on Nitric Oxide. Does anyone know if his book > > brought on the idea? > > I can't know Dr. Nase's contribution, which may have been everything, > but I would suspect that the researchers (responsible for discovering > the identity of the long sought 'endothelial relaxing factor' as > nitric oxide in the early 1980s) having just won the 1998 Nobel > Prize, had more to do with it. And I'm sure that the research would > be conducted at Harvard didn't hurt, either. > > Research into nitric oxide's role in vasodilation has been hot for > many years now, in many areas of medicine. For example, I believe > it's how Viagra works. > > Anyone know the prevailing theory, and evidence, regarding nitric > oxide and vascular components of rosacea? (I assume the theory is > that easy flushing is related to increased production/decreased > destruction/increased sensitivity to nitric oxide to the central > face's vasculature, selectively?) > > Marjorie > > Marjorie Lazoff, MD Quote Link to comment Share on other sites More sharing options...
Guest guest Posted April 20, 2002 Report Share Posted April 20, 2002 From what I've heard, Dr Lerner's original experiment funded by the NRS was a bit of a dud. The NRS says the results were " inconclusive " and Dr. Lerner was unable to get things working the way he wanted to. I don't know the details, I was informed about this last part by someone else on this list a few months ago. I dont think he's given up, and he is trying to change the delivery system or something (again not sure on the details) but initial results are not very promising Adam Quote Link to comment Share on other sites More sharing options...
Guest guest Posted April 20, 2002 Report Share Posted April 20, 2002 > From what I've heard, Dr Lerner's original experiment funded by the NRS was > a bit of a dud. The NRS says the results were " inconclusive " and Dr. Lerner > was unable to get things working the way he wanted to. I don't know the > details, I was informed about this last part by someone else on this list a > few months ago. I dont think he's given up, and he is trying to change the > delivery system or something (again not sure on the details) but initial > results are not very promising I'm not surprised, Adam. When the NRS write-up said (something along the lines of) it's too early to know the results of Dr. Lerner's research, that usually means that the early results aren't what was hoped for. Otherwise, the catch phrase is, " early results look promising... " But nothing is ever based on just one study. Marjorie Marjorie Lazoff, MD > Adam Quote Link to comment Share on other sites More sharing options...
Guest guest Posted April 20, 2002 Report Share Posted April 20, 2002 > From what I've heard, Dr Lerner's original experiment funded by the NRS was > a bit of a dud. The NRS says the results were " inconclusive " and Dr. Lerner > was unable to get things working the way he wanted to. I don't know the > details, I was informed about this last part by someone else on this list a > few months ago. I dont think he's given up, and he is trying to change the > delivery system or something (again not sure on the details) but initial > results are not very promising I'm not surprised, Adam. When the NRS write-up said (something along the lines of) it's too early to know the results of Dr. Lerner's research, that usually means that the early results aren't what was hoped for. Otherwise, the catch phrase is, " early results look promising... " But nothing is ever based on just one study. Marjorie Marjorie Lazoff, MD > Adam Quote Link to comment Share on other sites More sharing options...
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