Guest guest Posted April 13, 2002 Report Share Posted April 13, 2002 > Dr. Nase's intent was to use the small proceeds from the sale of > his book to allow him to continue his independent research and > advocacy on our behalf. Thanks, . I must be missing something. I'm not familiar with scientific research that's funded by the researcher. Unlike independent filmaking or running for a political office -- both cases where maxing out one's credit cards can pay off in the end -- scientific research is funded by outside sources. That's an important check-and-balance, since whoever funds a research project also maintain a close eye on the process and results, to insure accuracy and give the study credibility. If self-funded, a researcher can report any result -- they don't even have to run an experiment, there's no one to verify anything. That's why one of the main critera in judging the quality of research is who funds the research, and those who have no vested interest in the outcome are considered the most credible, like the government or universities or some private foundations. Certainly, the researcher him/herself has the most vested interest in the outcome of the research, even more than a pharmaceutical company, whose funding is usually viewed as most suspect. Or are you referring to some other kind of independent research, not scientific research performed in a lab? And can you tell us more about " the advocacy on our behalf " ? Do you know what he wants to advocate, and what costs are involved? Perhaps there's something others can do? I tried ordering the book a while ago, but the Web site wasn't functioning properly and there was no easy way for me to purchase the book. I was told that a phone line would be available soon. I see how much Dr. Nase is respected in this group, and how anxious people here are to help him, personally and professionally. Marjorie Marjorie Lazoff, MD Quote Link to comment Share on other sites More sharing options...
Guest guest Posted April 13, 2002 Report Share Posted April 13, 2002 I just wanted to say I agree, Dr. Nase has done a lot for this group and for the disease itself. It is a shame that his book is not doing better...btw, everyone on the group should have it. Its worth far more than the cost. In general though, you have to write a book like this for the passion of it, because it rarely will make you money and I think he probably knew that getting into it. It just downright sucks that Dr. Nase has been hurt, he has done so much for us. Just wanted to throw my two cents in. Pascoe wrote: >Dr. Nase's intent was to use the small proceeds from the sale of his book >to allow him to continue his independent research and advocacy on our >behalf. This has not been the reality he had hoped so far because of 2 >main reasons - his injury and the lower than expected sales of the book. > >Geoffrey is one of the best friends that this group could ever hope for. >If would be a loss for us all if he is not resourced (i.e. income) such >that he can continue his work. > >davidp. >-- > Pascoe, mailto:dp@..., South Perth, Western Australia > >On Saturday, 13 April 2002, at 16:15:45 [GMT -0000] you wrote: > >e> Patty, can you explain how buying his book supports his ongoing >e> research? Or are you referring to something else? > >e> Marjorie > >e> Marjorie Lazoff, MD > > >-- >Please read the list highlights before posting to the whole group (http://rosacea.ii.net/toc.html). Your post will be delayed if you don't give a meaningful subject or trim your reply text. You must change the subject when replying to a digest ! > >See http://www.drnase.com for info on his recently published book. > >To leave the list send an email to rosacea-support-unsubscribe > > Quote Link to comment Share on other sites More sharing options...
Guest guest Posted April 13, 2002 Report Share Posted April 13, 2002 I just wanted to say I agree, Dr. Nase has done a lot for this group and for the disease itself. It is a shame that his book is not doing better...btw, everyone on the group should have it. Its worth far more than the cost. In general though, you have to write a book like this for the passion of it, because it rarely will make you money and I think he probably knew that getting into it. It just downright sucks that Dr. Nase has been hurt, he has done so much for us. Just wanted to throw my two cents in. Pascoe wrote: >Dr. Nase's intent was to use the small proceeds from the sale of his book >to allow him to continue his independent research and advocacy on our >behalf. This has not been the reality he had hoped so far because of 2 >main reasons - his injury and the lower than expected sales of the book. > >Geoffrey is one of the best friends that this group could ever hope for. >If would be a loss for us all if he is not resourced (i.e. income) such >that he can continue his work. > >davidp. >-- > Pascoe, mailto:dp@..., South Perth, Western Australia > >On Saturday, 13 April 2002, at 16:15:45 [GMT -0000] you wrote: > >e> Patty, can you explain how buying his book supports his ongoing >e> research? Or are you referring to something else? > >e> Marjorie > >e> Marjorie Lazoff, MD > > >-- >Please read the list highlights before posting to the whole group (http://rosacea.ii.net/toc.html). Your post will be delayed if you don't give a meaningful subject or trim your reply text. You must change the subject when replying to a digest ! > >See http://www.drnase.com for info on his recently published book. > >To leave the list send an email to rosacea-support-unsubscribe > > Quote Link to comment Share on other sites More sharing options...
Guest guest Posted April 16, 2002 Report Share Posted April 16, 2002 meant for the group This is a forwarded message To: rosacea-support-owner Cc: Date: Tuesday, April 16, 2002, 11:44:25 AM Subject: Re: Dr. Nase Book on cea ===8<==============Original message text=============== > > > > > Dr. Nase's intent was to use the small proceeds from the sale of > > > his book to allow him to continue his independent research and > > > advocacy on our behalf. > > > > Thanks, . I must be missing something. I'm not familiar with > > scientific research that's funded by the researcher. Unlike > > independent filmaking or running for a political office -- both > cases > > where maxing out one's credit cards can pay off in the end -- > > scientific research is funded by outside sources. That's an > important > > check-and-balance, since whoever funds a research project also > > maintain a close eye on the process and results, to insure accuracy > > and give the study credibility. If self-funded, a researcher can > > report any result -- they don't even have to run an experiment, > > there's no one to verify anything. > > > > That's why one of the main critera in judging the quality of > research > > is who funds the research, and those who have no vested interest in > > the outcome are considered the most credible, like the government > or > > universities or some private foundations. Certainly, the researcher > > him/herself has the most vested interest in the outcome of the > > research, even more than a pharmaceutical company, whose funding is > > usually viewed as most suspect. > > > > Or are you referring to some other kind of independent research, > not > > scientific research performed in a lab? And can you tell us more > > about " the advocacy on our behalf " ? Do you know what he wants to > > advocate, and what costs are involved? Perhaps there's something > > others can do? > > > > I tried ordering the book a while ago, but the Web site wasn't > > functioning properly and there was no easy way for me to purchase > the > > book. I was told that a phone line would be available soon. > > > > I see how much Dr. Nase is respected in this group, and how anxious > > people here are to help him, personally and professionally. > > > > Marjorie > > > > Marjorie Lazoff, MD ===8<===========End of original message text=========== Quote Link to comment Share on other sites More sharing options...
Guest guest Posted April 16, 2002 Report Share Posted April 16, 2002 I think this message was meant for the group. Matija Date: Tue, 16 Apr 2002 17:53:48 -0000 There IS a lot of indirect research out there that can benefit rosacea sufferers. If you read Dr. Nase's book, you will find a well organized procurement of it. Dr nase tracked it all down and organized it in his book to educate and SPUR FURTHER RESEARCH. He also interviewed many, many doctors and summarized what he learned. Incidently, not long after Dr. Nase published, the NRS funded someone to research on Nitric Oxide. Does anyone know if his book brought on the idea? The book is not his main career. He has a full time job as a microvascular physiologist or something like that on top of it. Funding or no funding Dr. Nases book changed my life for the better. Mine was so incredibly painful and debilitating. Now after reading his book and being a member of this group I am so much better. Thank you, thank you, thank you Dr. Nase!! I hope you can keep up your research. Patty > > > > > > > Dr. Nase's intent was to use the small proceeds from the sale > of > > > > his book to allow him to continue his independent research and > > > > advocacy on our behalf. > > > > > > Thanks, . I must be missing something. I'm not familiar with > > > scientific research that's funded by the researcher. Unlike > > > independent filmaking or running for a political office -- both > > cases > > > where maxing out one's credit cards can pay off in the end - - > > > scientific research is funded by outside sources. That's an > > important > > > check-and-balance, since whoever funds a research project also > > > maintain a close eye on the process and results, to insure > accuracy > > > and give the study credibility. If self-funded, a researcher can > > > report any result -- they don't even have to run an experiment, > > > there's no one to verify anything. > > > > > > That's why one of the main critera in judging the quality of > > research > > > is who funds the research, and those who have no vested interest > in > > > the outcome are considered the most credible, like the government > > or > > > universities or some private foundations. Certainly, the > researcher > > > him/herself has the most vested interest in the outcome of the > > > research, even more than a pharmaceutical company, whose funding > is > > > usually viewed as most suspect. > > > > > > Or are you referring to some other kind of independent research, > > not > > > scientific research performed in a lab? And can you tell us more > > > about " the advocacy on our behalf " ? Do you know what he wants to > > > advocate, and what costs are involved? Perhaps there's something > > > others can do? > > > > > > I tried ordering the book a while ago, but the Web site wasn't > > > functioning properly and there was no easy way for me to purchase > > the > > > book. I was told that a phone line would be available soon. > > > > > > I see how much Dr. Nase is respected in this group, and how > anxious > > > people here are to help him, personally and professionally. > > > > > > Marjorie > > > > > > Marjorie Lazoff, MD > > > > ===8<===========End of original message text=========== Quote Link to comment Share on other sites More sharing options...
Guest guest Posted April 18, 2002 Report Share Posted April 18, 2002 > Incidently, not long after Dr. Nase published, the NRS funded > someone to research on Nitric Oxide. Does anyone know if his book > brought on the idea? Patty, vascular research on nitric oxide is a hot topic, ever since it was identified as the endothelial relaxing factor in the early 1980s. In fact, the 1998 Nobel Prize went to the original researchers for their discovery of nitric oxide. I don't know much about it, but I understand it is of interest to many disorders; for example, I believe the pharmacology of Viagra involves nitric oxide, and it has also been postulated in the mechanism of essential hypertension. I gather the theory regarding nitric oxide and rosacea involves an overproduction of NO/increased number or activity of NO receptors/decreased breakdown of NO/oversensitivity of vascular smooth muscles, etc. involving the vessels of the central face. Can someone enlighten me as to the precise theory, and where I might locate support for the theory in the medical literature? Thanks, Marjorie Marjorie Lazoff, MD Quote Link to comment Share on other sites More sharing options...
Guest guest Posted April 18, 2002 Report Share Posted April 18, 2002 > Incidently, not long after Dr. Nase published, the NRS funded > someone to research on Nitric Oxide. Does anyone know if his book > brought on the idea? Patty, vascular research on nitric oxide is a hot topic, ever since it was identified as the endothelial relaxing factor in the early 1980s. In fact, the 1998 Nobel Prize went to the original researchers for their discovery of nitric oxide. I don't know much about it, but I understand it is of interest to many disorders; for example, I believe the pharmacology of Viagra involves nitric oxide, and it has also been postulated in the mechanism of essential hypertension. I gather the theory regarding nitric oxide and rosacea involves an overproduction of NO/increased number or activity of NO receptors/decreased breakdown of NO/oversensitivity of vascular smooth muscles, etc. involving the vessels of the central face. Can someone enlighten me as to the precise theory, and where I might locate support for the theory in the medical literature? Thanks, Marjorie Marjorie Lazoff, MD Quote Link to comment Share on other sites More sharing options...
Guest guest Posted April 18, 2002 Report Share Posted April 18, 2002 Marjorie, If you search in the archives for this group using a Lerner & Harvard search string, you'll find a copy of an abstract that Ethan Lerner, MD, from Harvard Med School wrote about his hypothesis regarding NO and rosacea. It's a very helpful document that I posted during 1/2001 (sorry if I have the month/year wrong). Take care, Matija > > Incidently, not long after Dr. Nase published, the NRS funded > > someone to research on Nitric Oxide. Does anyone know if his book > > brought on the idea? > > Patty, vascular research on nitric oxide is a hot topic, ever since > it was identified as the endothelial relaxing factor in the early > 1980s. In fact, the 1998 Nobel Prize went to the original researchers > for their discovery of nitric oxide. I don't know much about it, but > I understand it is of interest to many disorders; for example, I > believe the pharmacology of Viagra involves nitric oxide, and it has > also been postulated in the mechanism of essential hypertension. > > I gather the theory regarding nitric oxide and rosacea involves an > overproduction of NO/increased number or activity of NO > receptors/decreased breakdown of NO/oversensitivity of vascular > smooth muscles, etc. involving the vessels of the central face. Can > someone enlighten me as to the precise theory, and where I might > locate support for the theory in the medical literature? > > Thanks, > > Marjorie > > Marjorie Lazoff, MD Quote Link to comment Share on other sites More sharing options...
Guest guest Posted April 19, 2002 Report Share Posted April 19, 2002 Marjorie, That's not the article I was referring to. (I'm sorry. I should have searched for it and provided you the link myself.) It's an abstract by Ethan Lerner, MD, regarding his hypothesis on NO and rosacea. Here's a link to it if you're interested in it. http://groups.yahoo.com/group/rosacea-support/message/24047 Take care, Matija > > > > Incidently, not long after Dr. Nase published, the NRS funded > > > > someone to research on Nitric Oxide. Does anyone know if his > > book > > > > brought on the idea? > > > > > > Patty, vascular research on nitric oxide is a hot topic, ever > since > > > it was identified as the endothelial relaxing factor in the early > > > 1980s. In fact, the 1998 Nobel Prize went to the original > > researchers > > > for their discovery of nitric oxide. I don't know much about it, > > but > > > I understand it is of interest to many disorders; for example, I > > > believe the pharmacology of Viagra involves nitric oxide, and it > > has > > > also been postulated in the mechanism of essential hypertension. > > > > > > I gather the theory regarding nitric oxide and rosacea involves > an > > > overproduction of NO/increased number or activity of NO > > > receptors/decreased breakdown of NO/oversensitivity of vascular > > > smooth muscles, etc. involving the vessels of the central face. > Can > > > someone enlighten me as to the precise theory, and where I might > > > locate support for the theory in the medical literature? > > > > > > Thanks, > > > > > > Marjorie > > > > > > Marjorie Lazoff, MD Quote Link to comment Share on other sites More sharing options...
Guest guest Posted April 19, 2002 Report Share Posted April 19, 2002 > > > > > Incidently, not long after Dr. Nase published, the NRS funded > > > > > someone to research on Nitric Oxide. Does anyone know if his > > > book > > > > > brought on the idea? > > > > > > > > Patty, vascular research on nitric oxide is a hot topic, ever > > since > > > > it was identified as the endothelial relaxing factor in the > early > > > > 1980s. In fact, the 1998 Nobel Prize went to the original > > > researchers > > > > for their discovery of nitric oxide. I don't know much about > it, > > > but > > > > I understand it is of interest to many disorders; for example, > I > > > > believe the pharmacology of Viagra involves nitric oxide, and > it > > > has > > > > also been postulated in the mechanism of essential > hypertension. > > > > > > > > I gather the theory regarding nitric oxide and rosacea involves > > an > > > > overproduction of NO/increased number or activity of NO > > > > receptors/decreased breakdown of NO/oversensitivity of vascular > > > > smooth muscles, etc. involving the vessels of the central face. > > Can > > > > someone enlighten me as to the precise theory, and where I > might > > > > locate support for the theory in the medical literature? > > > > > > > > Thanks, > > > > > > > > Marjorie > > > > > > > > Marjorie Lazoff, MD Quote Link to comment Share on other sites More sharing options...
Guest guest Posted April 19, 2002 Report Share Posted April 19, 2002 > > > > > Incidently, not long after Dr. Nase published, the NRS funded > > > > > someone to research on Nitric Oxide. Does anyone know if his > > > book > > > > > brought on the idea? > > > > > > > > Patty, vascular research on nitric oxide is a hot topic, ever > > since > > > > it was identified as the endothelial relaxing factor in the > early > > > > 1980s. In fact, the 1998 Nobel Prize went to the original > > > researchers > > > > for their discovery of nitric oxide. I don't know much about > it, > > > but > > > > I understand it is of interest to many disorders; for example, > I > > > > believe the pharmacology of Viagra involves nitric oxide, and > it > > > has > > > > also been postulated in the mechanism of essential > hypertension. > > > > > > > > I gather the theory regarding nitric oxide and rosacea involves > > an > > > > overproduction of NO/increased number or activity of NO > > > > receptors/decreased breakdown of NO/oversensitivity of vascular > > > > smooth muscles, etc. involving the vessels of the central face. > > Can > > > > someone enlighten me as to the precise theory, and where I > might > > > > locate support for the theory in the medical literature? > > > > > > > > Thanks, > > > > > > > > Marjorie > > > > > > > > Marjorie Lazoff, MD Quote Link to comment Share on other sites More sharing options...
Guest guest Posted April 19, 2002 Report Share Posted April 19, 2002 It would be wonderful if you could find any new information or progress in this area. Dr. Nase used L-Name in a non-irritating base formulated at his lab on himself at first. Then he started recruiting doctors to participate in a study. Then he got in a terrible car accident and I am not sure what came of the study or if they were able to finish it. Thanks!!!! Patty > > > > Incidently, not long after Dr. Nase published, the NRS funded > > > > someone to research on Nitric Oxide. Does anyone know if his > > book > > > > brought on the idea? > > > > > > Patty, vascular research on nitric oxide is a hot topic, ever > since > > > it was identified as the endothelial relaxing factor in the early > > > 1980s. In fact, the 1998 Nobel Prize went to the original > > researchers > > > for their discovery of nitric oxide. I don't know much about it, > > but > > > I understand it is of interest to many disorders; for example, I > > > believe the pharmacology of Viagra involves nitric oxide, and it > > has > > > also been postulated in the mechanism of essential hypertension. > > > > > > I gather the theory regarding nitric oxide and rosacea involves > an > > > overproduction of NO/increased number or activity of NO > > > receptors/decreased breakdown of NO/oversensitivity of vascular > > > smooth muscles, etc. involving the vessels of the central face. > Can > > > someone enlighten me as to the precise theory, and where I might > > > locate support for the theory in the medical literature? > > > > > > Thanks, > > > > > > Marjorie > > > > > > Marjorie Lazoff, MD Quote Link to comment Share on other sites More sharing options...
Guest guest Posted April 19, 2002 Report Share Posted April 19, 2002 It would be wonderful if you could find any new information or progress in this area. Dr. Nase used L-Name in a non-irritating base formulated at his lab on himself at first. Then he started recruiting doctors to participate in a study. Then he got in a terrible car accident and I am not sure what came of the study or if they were able to finish it. Thanks!!!! Patty > > > > Incidently, not long after Dr. Nase published, the NRS funded > > > > someone to research on Nitric Oxide. Does anyone know if his > > book > > > > brought on the idea? > > > > > > Patty, vascular research on nitric oxide is a hot topic, ever > since > > > it was identified as the endothelial relaxing factor in the early > > > 1980s. In fact, the 1998 Nobel Prize went to the original > > researchers > > > for their discovery of nitric oxide. I don't know much about it, > > but > > > I understand it is of interest to many disorders; for example, I > > > believe the pharmacology of Viagra involves nitric oxide, and it > > has > > > also been postulated in the mechanism of essential hypertension. > > > > > > I gather the theory regarding nitric oxide and rosacea involves > an > > > overproduction of NO/increased number or activity of NO > > > receptors/decreased breakdown of NO/oversensitivity of vascular > > > smooth muscles, etc. involving the vessels of the central face. > Can > > > someone enlighten me as to the precise theory, and where I might > > > locate support for the theory in the medical literature? > > > > > > Thanks, > > > > > > Marjorie > > > > > > Marjorie Lazoff, MD Quote Link to comment Share on other sites More sharing options...
Guest guest Posted April 19, 2002 Report Share Posted April 19, 2002 It would be wonderful if you could find any new information or progress in this area. Dr. Nase used L-Name in a non-irritating base formulated at his lab on himself at first. Then he started recruiting doctors to participate in a study. Then he got in a terrible car accident and I am not sure what came of the study or if they were able to finish it. Thanks!!!! Patty > > > > Incidently, not long after Dr. Nase published, the NRS funded > > > > someone to research on Nitric Oxide. Does anyone know if his > > book > > > > brought on the idea? > > > > > > Patty, vascular research on nitric oxide is a hot topic, ever > since > > > it was identified as the endothelial relaxing factor in the early > > > 1980s. In fact, the 1998 Nobel Prize went to the original > > researchers > > > for their discovery of nitric oxide. I don't know much about it, > > but > > > I understand it is of interest to many disorders; for example, I > > > believe the pharmacology of Viagra involves nitric oxide, and it > > has > > > also been postulated in the mechanism of essential hypertension. > > > > > > I gather the theory regarding nitric oxide and rosacea involves > an > > > overproduction of NO/increased number or activity of NO > > > receptors/decreased breakdown of NO/oversensitivity of vascular > > > smooth muscles, etc. involving the vessels of the central face. > Can > > > someone enlighten me as to the precise theory, and where I might > > > locate support for the theory in the medical literature? > > > > > > Thanks, > > > > > > Marjorie > > > > > > Marjorie Lazoff, MD Quote Link to comment Share on other sites More sharing options...
Guest guest Posted April 20, 2002 Report Share Posted April 20, 2002 From what I've heard, Dr Lerner's original experiment funded by the NRS was a bit of a dud. The NRS says the results were " inconclusive " and Dr. Lerner was unable to get things working the way he wanted to. I don't know the details, I was informed about this last part by someone else on this list a few months ago. I dont think he's given up, and he is trying to change the delivery system or something (again not sure on the details) but initial results are not very promising Adam Quote Link to comment Share on other sites More sharing options...
Guest guest Posted April 20, 2002 Report Share Posted April 20, 2002 > From what I've heard, Dr Lerner's original experiment funded by the NRS was > a bit of a dud. The NRS says the results were " inconclusive " and Dr. Lerner > was unable to get things working the way he wanted to. I don't know the > details, I was informed about this last part by someone else on this list a > few months ago. I dont think he's given up, and he is trying to change the > delivery system or something (again not sure on the details) but initial > results are not very promising I'm not surprised, Adam. When the NRS write-up said (something along the lines of) it's too early to know the results of Dr. Lerner's research, that usually means that the early results aren't what was hoped for. Otherwise, the catch phrase is, " early results look promising... " But nothing is ever based on just one study. Marjorie Marjorie Lazoff, MD > Adam Quote Link to comment Share on other sites More sharing options...
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