Guest guest Posted April 26, 2002 Report Share Posted April 26, 2002 Long term use of low dose accutane has potentially serious side effects and few patients are appropriate candidates for therapy. The most devastating side effect is teratogenicity, but other serious side effects include hyperlipidemia, neutropenia, anemia, and hepatitis. Mucocutaneous adverse effects include cheilitis, xerosis, conjunctivitis, urethritis, and hair loss. Long term use has been associated with the development of diffuse idiopathic skeletal hyperostosis (DISH). This agent must be used cautiously and only by physicians who are well versed in all of its adverse effects. Quote Link to comment Share on other sites More sharing options...
Guest guest Posted April 26, 2002 Report Share Posted April 26, 2002 > Long term use of low dose accutane has potentially > serious side effects and few patients are appropriate > candidates for therapy. The most devastating side effect is > teratogenicity, It is not teratogenic for males. And this is really not a devestating effect for females either because all they need to do is get on birth control, and the right birth control pill will improve their rosacea, ie. ortho tri cyclin. but other serious side effects include hyperlipidemia, > neutropenia, anemia, and hepatitis. Mucocutaneous adverse > effects include cheilitis, xerosis, conjunctivitis, urethritis, and > hair loss. That is mainly on high dose accutane. Look at some pictures of patients on high dose accutane. Their skin is extremely dry, the cheilitis is very bad (if they don't apply vaseline), and then imagine a rosacea patient on high dose accutane. His face would look much more horrible that the normal acne patient because there would be an EXTREME flush in the rosacea prone areas of the face. It would effectively worsen the rosacea. That is why rosacea sufferes who do low dose accutane must never exceed 10 mg / day and at the first sign of xerosis must switch to 10 mg qod and also to not take their accutane with a very large high fat meal. The hair loss thing is variable. Different amounts for different people. Be glad you don't have psoriasis because soriatane causes much more hair loss than accutane. Which brings up another point. all the aromatic retinoids are just as tetatogenic as accutane and they have much much longer half lives, why isn't there a smart program from those? Anyways. those who tend to hair loss on accutane should be on 10 mg qod and combine it with either minocyline or zithromax. Long term use has been associated with the development > of diffuse idiopathic skeletal hyperostosis (DISH). This agent > must be used cautiously and only by physicians who are well > versed in all of its adverse effects. > > this usually occurs after three or more full doses of accutane. long term 10 mg qod or 10 mg qd would take decades for this to occur. you'd probably be long gone before this happens. once again, it is important when one is on accutane to be acutely aware if you are one who absorbs more than usual at the 10mg/d dose. if you flush or you notice your skin too dry, it is time to titrate the dose back. with rosacea and accutane, less is more. > Quote Link to comment Share on other sites More sharing options...
Guest guest Posted April 26, 2002 Report Share Posted April 26, 2002 > Long term use of low dose accutane has potentially > serious side effects and few patients are appropriate > candidates for therapy. The most devastating side effect is > teratogenicity, It is not teratogenic for males. And this is really not a devestating effect for females either because all they need to do is get on birth control, and the right birth control pill will improve their rosacea, ie. ortho tri cyclin. but other serious side effects include hyperlipidemia, > neutropenia, anemia, and hepatitis. Mucocutaneous adverse > effects include cheilitis, xerosis, conjunctivitis, urethritis, and > hair loss. That is mainly on high dose accutane. Look at some pictures of patients on high dose accutane. Their skin is extremely dry, the cheilitis is very bad (if they don't apply vaseline), and then imagine a rosacea patient on high dose accutane. His face would look much more horrible that the normal acne patient because there would be an EXTREME flush in the rosacea prone areas of the face. It would effectively worsen the rosacea. That is why rosacea sufferes who do low dose accutane must never exceed 10 mg / day and at the first sign of xerosis must switch to 10 mg qod and also to not take their accutane with a very large high fat meal. The hair loss thing is variable. Different amounts for different people. Be glad you don't have psoriasis because soriatane causes much more hair loss than accutane. Which brings up another point. all the aromatic retinoids are just as tetatogenic as accutane and they have much much longer half lives, why isn't there a smart program from those? Anyways. those who tend to hair loss on accutane should be on 10 mg qod and combine it with either minocyline or zithromax. Long term use has been associated with the development > of diffuse idiopathic skeletal hyperostosis (DISH). This agent > must be used cautiously and only by physicians who are well > versed in all of its adverse effects. > > this usually occurs after three or more full doses of accutane. long term 10 mg qod or 10 mg qd would take decades for this to occur. you'd probably be long gone before this happens. once again, it is important when one is on accutane to be acutely aware if you are one who absorbs more than usual at the 10mg/d dose. if you flush or you notice your skin too dry, it is time to titrate the dose back. with rosacea and accutane, less is more. > Quote Link to comment Share on other sites More sharing options...
Guest guest Posted April 26, 2002 Report Share Posted April 26, 2002 > Long term use of low dose accutane has potentially > serious side effects and few patients are appropriate > candidates for therapy. The most devastating side effect is > teratogenicity, It is not teratogenic for males. And this is really not a devestating effect for females either because all they need to do is get on birth control, and the right birth control pill will improve their rosacea, ie. ortho tri cyclin. but other serious side effects include hyperlipidemia, > neutropenia, anemia, and hepatitis. Mucocutaneous adverse > effects include cheilitis, xerosis, conjunctivitis, urethritis, and > hair loss. That is mainly on high dose accutane. Look at some pictures of patients on high dose accutane. Their skin is extremely dry, the cheilitis is very bad (if they don't apply vaseline), and then imagine a rosacea patient on high dose accutane. His face would look much more horrible that the normal acne patient because there would be an EXTREME flush in the rosacea prone areas of the face. It would effectively worsen the rosacea. That is why rosacea sufferes who do low dose accutane must never exceed 10 mg / day and at the first sign of xerosis must switch to 10 mg qod and also to not take their accutane with a very large high fat meal. The hair loss thing is variable. Different amounts for different people. Be glad you don't have psoriasis because soriatane causes much more hair loss than accutane. Which brings up another point. all the aromatic retinoids are just as tetatogenic as accutane and they have much much longer half lives, why isn't there a smart program from those? Anyways. those who tend to hair loss on accutane should be on 10 mg qod and combine it with either minocyline or zithromax. Long term use has been associated with the development > of diffuse idiopathic skeletal hyperostosis (DISH). This agent > must be used cautiously and only by physicians who are well > versed in all of its adverse effects. > > this usually occurs after three or more full doses of accutane. long term 10 mg qod or 10 mg qd would take decades for this to occur. you'd probably be long gone before this happens. once again, it is important when one is on accutane to be acutely aware if you are one who absorbs more than usual at the 10mg/d dose. if you flush or you notice your skin too dry, it is time to titrate the dose back. with rosacea and accutane, less is more. > Quote Link to comment Share on other sites More sharing options...
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