Long term use of accutane.

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Long term use of low dose accutane has potentially

serious side effects and few patients are appropriate

candidates for therapy. The most devastating side effect is

teratogenicity, but other serious side effects include hyperlipidemia,

neutropenia, anemia, and hepatitis. Mucocutaneous adverse

effects include cheilitis, xerosis, conjunctivitis, urethritis, and

hair loss. Long term use has been associated with the development

of diffuse idiopathic skeletal hyperostosis (DISH). This agent

must be used cautiously and only by physicians who are well

versed in all of its adverse effects.