Guest guest Posted April 27, 2002 Report Share Posted April 27, 2002 An interesting abstract to follow. I have noted that several web sites mention sulfur as being non comedogenic if it is precipitated sulfur. Perhaps, there are too many impurities in the production of sulfur by other methods besides precipitation. Sulfur is very useful against yeasts and fungi, whatever you want to call them. It is also a good anti-inflammatory without the baggage anti-inflammatories usually carry. Comedogenicity of current therapeutic products, cosmetics, and ingredients in the rabbit ear. Fulton JE Jr, Pay SR, Fulton JE 3rd. Cosmetics continue to be used by acne-prone individuals. Often as more acne develops, more cosmetics are applied. In order to protect against this natural tendency, physicians should provide more patient information on the currently available products and ingredients. This presentation is designed to help in that effort. The data presented were gleaned from the rabbit ear assay, which is not an ideal animal model but is the best we have. If an ingredient is negative in the rabbit ear assay, we feel it is safe on the acne-prone skin. A strong, positive ingredient or cosmetic should be avoided. Ingredient offenders include isopropyl myristate and its analogs, such as isopropyl palmitate, isopropyl isostearate, butyl stearate, isostearyl neopentanoate, myristyl myristate, decyl oleate, octyl stearate, octyl palmitate or isocetyl stearate, and new introductions by the cosmetic industry, such as propylene glycol-2 (PPG-2) myristyl propionate. Lanolins continue to be a problem, especially derivatives such as acetylated or ethoxylated lanolins. Our most troublesome recent finding is the comedogenic potential of the D & C Red dyes. They are universally used in the cosmetic industry, especially in blushers. This may explain the predominance of cosmetic acne in the cheekbone area. All of these D & C Red dyes tested to date, the xanthenes, monoazoanilines, fluorans, and indigoids, are comedogenic. Actually, this is not surprising as they are coal tar derivatives. The natural red pigment, carmine, is noncomedogenic and can serve as a substitute for D & C dyes in blushers. Many finished products are comedogenic. Most troublesome to the dermatologists are the therapeutic tools that we use, such as Liquimat, Retin-A cream, Hytone, Staticin, Sulfoxl, Desquam-X, and Persadox HP cream. These should be reformulated. We have been unable to confirm that precipitated sulfur (U.S.P.) is a potent comedogen in the rabbit ear assay. Clinically, we still find sulfur quite effective as an adjuvant to the benzoyl peroxide therapy for the treatment of acne vulgaris. We would suggest that the bias against sulfur be reconsidered. Quote Link to comment Share on other sites More sharing options...
Guest guest Posted April 27, 2002 Report Share Posted April 27, 2002 on 4/27/02 4:16 PM, doubleoh7_mi6 at ciz@... wrote: > Cosmetics continue to be used by acne-prone individuals. Often as > more acne develops, more cosmetics are applied. In order to protect > against this natural tendency, physicians should provide more patient > information on the currently available products and ingredients. This > presentation is designed to help in that effort. The data presented > were gleaned from the rabbit ear assay, which is not an ideal animal > model but is the best we have. If an ingredient is negative in the > rabbit ear assay, we feel it is safe on the acne-prone skin. A > strong, positive ingredient or cosmetic should be avoided. Ingredient > offenders include isopropyl myristate and its analogs, such as > isopropyl palmitate, isopropyl isostearate, butyl stearate, > isostearyl neopentanoate, myristyl myristate, decyl oleate, octyl > stearate, octyl palmitate or isocetyl stearate, and new introductions > by the cosmetic industry, such as propylene glycol-2 (PPG-2) myristyl > propionate. Double o, this article is saying that these ingredients can cause problems like acne or " clogged pores " ? > Lanolins continue to be a problem, especially derivatives > such as acetylated or ethoxylated lanolins. Our most troublesome > recent finding is the comedogenic potential of the D & C Red dyes. > They are universally used in the cosmetic industry, especially in > blushers. This may explain the predominance of cosmetic acne in the > cheekbone area. All of these D & C Red dyes tested to date, the > xanthenes, monoazoanilines, fluorans, and indigoids, are comedogenic. Interesting. I've noticed this effect for years......it used to be that only some blushers caused bumps/irritation. Now they all seem too....for that reason I rarely used them anymore. > Actually, this is not surprising as they are coal tar derivatives. > The natural red pigment, carmine, is noncomedogenic and can serve as > a substitute for D & C dyes in blushers. Many finished products are > comedogenic. Most troublesome to the dermatologists are the > therapeutic tools that we use, such as Liquimat, Retin-A cream, > Hytone, Staticin, Sulfoxl, Desquam-X, and Persadox HP cream. These > should be reformulated. We have been unable to confirm that > precipitated sulfur (U.S.P.) is a potent comedogen in the rabbit ear > assay. Clinically, we still find sulfur quite effective as an > adjuvant to the benzoyl peroxide therapy for the treatment of acne > vulgaris. We would suggest that the bias against sulfur be > reconsidered. Quote Link to comment Share on other sites More sharing options...
Guest guest Posted April 27, 2002 Report Share Posted April 27, 2002 on 4/27/02 4:16 PM, doubleoh7_mi6 at ciz@... wrote: > Cosmetics continue to be used by acne-prone individuals. Often as > more acne develops, more cosmetics are applied. In order to protect > against this natural tendency, physicians should provide more patient > information on the currently available products and ingredients. This > presentation is designed to help in that effort. The data presented > were gleaned from the rabbit ear assay, which is not an ideal animal > model but is the best we have. If an ingredient is negative in the > rabbit ear assay, we feel it is safe on the acne-prone skin. A > strong, positive ingredient or cosmetic should be avoided. Ingredient > offenders include isopropyl myristate and its analogs, such as > isopropyl palmitate, isopropyl isostearate, butyl stearate, > isostearyl neopentanoate, myristyl myristate, decyl oleate, octyl > stearate, octyl palmitate or isocetyl stearate, and new introductions > by the cosmetic industry, such as propylene glycol-2 (PPG-2) myristyl > propionate. Double o, this article is saying that these ingredients can cause problems like acne or " clogged pores " ? > Lanolins continue to be a problem, especially derivatives > such as acetylated or ethoxylated lanolins. Our most troublesome > recent finding is the comedogenic potential of the D & C Red dyes. > They are universally used in the cosmetic industry, especially in > blushers. This may explain the predominance of cosmetic acne in the > cheekbone area. All of these D & C Red dyes tested to date, the > xanthenes, monoazoanilines, fluorans, and indigoids, are comedogenic. Interesting. I've noticed this effect for years......it used to be that only some blushers caused bumps/irritation. Now they all seem too....for that reason I rarely used them anymore. > Actually, this is not surprising as they are coal tar derivatives. > The natural red pigment, carmine, is noncomedogenic and can serve as > a substitute for D & C dyes in blushers. Many finished products are > comedogenic. Most troublesome to the dermatologists are the > therapeutic tools that we use, such as Liquimat, Retin-A cream, > Hytone, Staticin, Sulfoxl, Desquam-X, and Persadox HP cream. These > should be reformulated. We have been unable to confirm that > precipitated sulfur (U.S.P.) is a potent comedogen in the rabbit ear > assay. Clinically, we still find sulfur quite effective as an > adjuvant to the benzoyl peroxide therapy for the treatment of acne > vulgaris. We would suggest that the bias against sulfur be > reconsidered. Quote Link to comment Share on other sites More sharing options...
Guest guest Posted April 28, 2002 Report Share Posted April 28, 2002 > Thanks for this, 007! Where did this come from? I don't know anything Here's the full cite: J Am Acad Dermatol. 1984 Jan;10(1):96-105. PMID: 6229554 [PubMed - indexed for MEDLINE Many other similar on medline. > about sulfur, but it would be nice to create a comprehensive list of > comedogenic ingredients, and common skin irritants, somewhere for > everyone to contribute to and access. Maybe in association with > 's wonderful (and hopefully legal ) idea about posting > product ingredients? It's legal to look at the label, it should be legal to write the contents of a label down and we should. My hope is that we can post reviews and suggestions and forward them to the manufacturers to get them to reformulate their products in a non comedogenic manner. I think posted two great web sites which listed ingredients and their comedogenicty and irritancy index. I now have them bookmarked. Thanks One of the interesting things about sulfur is that it is active against pityrosporum ovale. a lot of people have concerns about this commensal in rosacea. another thing is that it also should have some activity against facial candida dermatitis, which can mimic rosacea (rarely). The vehicle is everything, it seems, sulfur is not the problem when it comes to comedogenicity... it is the vehicle. > > When you say yeast and fungi in a dermatologic context, you're > referring to both candida and non-candida dermatophytes (fungi that > cause skin infections in humans). In medical usage, unless you're > specifically referring to candida vaginitis which is commonly > referred to as a yeast infection, everything else is usually just > called a fungal infection. > > Marjorie > > Marjorie Lazoff, MD > > > > > > An interesting abstract to follow. I have noted that several web > > sites mention sulfur as being non comedogenic if it is precipitated > > sulfur. Perhaps, there are too many impurities in the production > of > > sulfur by other methods besides precipitation. Sulfur is very > useful > > against yeasts and fungi, whatever you want to call them. It is > also > > a good anti-inflammatory without the baggage anti-inflammatories > > usually carry. > > > > > > Comedogenicity of current therapeutic products, cosmetics, and > > ingredients in the rabbit ear. > > > > Fulton JE Jr, Pay SR, Fulton JE 3rd. > > > > Cosmetics continue to be used by acne-prone individuals. Often as > > more acne develops, more cosmetics are applied. In order to protect > > against this natural tendency, physicians should provide more > patient > > information on the currently available products and ingredients. > This > > presentation is designed to help in that effort. The data presented > > were gleaned from the rabbit ear assay, which is not an ideal > animal > > model but is the best we have. If an ingredient is negative in the > > rabbit ear assay, we feel it is safe on the acne-prone skin. A > > strong, positive ingredient or cosmetic should be avoided. > Ingredient > > offenders include isopropyl myristate and its analogs, such as > > isopropyl palmitate, isopropyl isostearate, butyl stearate, > > isostearyl neopentanoate, myristyl myristate, decyl oleate, octyl > > stearate, octyl palmitate or isocetyl stearate, and new > introductions > > by the cosmetic industry, such as propylene glycol-2 (PPG-2) > myristyl > > propionate. Lanolins continue to be a problem, especially > derivatives > > such as acetylated or ethoxylated lanolins. Our most troublesome > > recent finding is the comedogenic potential of the D & C Red dyes. > > They are universally used in the cosmetic industry, especially in > > blushers. This may explain the predominance of cosmetic acne in the > > cheekbone area. All of these D & C Red dyes tested to date, the > > xanthenes, monoazoanilines, fluorans, and indigoids, are > comedogenic. > > Actually, this is not surprising as they are coal tar derivatives. > > The natural red pigment, carmine, is noncomedogenic and can serve > as > > a substitute for D & C dyes in blushers. Many finished products are > > comedogenic. Most troublesome to the dermatologists are the > > therapeutic tools that we use, such as Liquimat, Retin-A cream, > > Hytone, Staticin, Sulfoxl, Desquam-X, and Persadox HP cream. These > > should be reformulated. We have been unable to confirm that > > precipitated sulfur (U.S.P.) is a potent comedogen in the rabbit > ear > > assay. Clinically, we still find sulfur quite effective as an > > adjuvant to the benzoyl peroxide therapy for the treatment of acne > > vulgaris. We would suggest that the bias against sulfur be > > reconsidered. Quote Link to comment Share on other sites More sharing options...
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