Guest guest Posted May 22, 2002 Report Share Posted May 22, 2002 I am assuming that the lipase levels you are referring to were measured in blood. Marjorie is more qualified than me to comment on the significance of reduced blood lipase levels in humans (if any). I will tell you that the pancreas is both an endocrine and exocrine organ, that is it secretes both enzymes for digestion and hormones. A reduction in the production of digestive enzymes in dogs is called Exocrine Pancreatic Insufficiency and results in an emaciated appearance and chronic severe diarrhoea (due to undigested food making it to the colon which, as you can imagine, makes the colonic flora stand up and salute). In any case, I don't see why a reduced production of lipase would result in an increase in postprandial lipaemia.........the opposite would be true. Quote Link to comment Share on other sites More sharing options...
Guest guest Posted May 22, 2002 Report Share Posted May 22, 2002 I am assuming that the lipase levels you are referring to were measured in blood. Marjorie is more qualified than me to comment on the significance of reduced blood lipase levels in humans (if any). I will tell you that the pancreas is both an endocrine and exocrine organ, that is it secretes both enzymes for digestion and hormones. A reduction in the production of digestive enzymes in dogs is called Exocrine Pancreatic Insufficiency and results in an emaciated appearance and chronic severe diarrhoea (due to undigested food making it to the colon which, as you can imagine, makes the colonic flora stand up and salute). In any case, I don't see why a reduced production of lipase would result in an increase in postprandial lipaemia.........the opposite would be true. Quote Link to comment Share on other sites More sharing options...
Guest guest Posted May 22, 2002 Report Share Posted May 22, 2002 I am assuming that the lipase levels you are referring to were measured in blood. Marjorie is more qualified than me to comment on the significance of reduced blood lipase levels in humans (if any). I will tell you that the pancreas is both an endocrine and exocrine organ, that is it secretes both enzymes for digestion and hormones. A reduction in the production of digestive enzymes in dogs is called Exocrine Pancreatic Insufficiency and results in an emaciated appearance and chronic severe diarrhoea (due to undigested food making it to the colon which, as you can imagine, makes the colonic flora stand up and salute). In any case, I don't see why a reduced production of lipase would result in an increase in postprandial lipaemia.........the opposite would be true. Quote Link to comment Share on other sites More sharing options...
Guest guest Posted May 22, 2002 Report Share Posted May 22, 2002 Englishtexvet, from what Adam has told us about the study, I'm far from convinced it identified an association between low lipase levels and rosacea. The percentage spread sounds unreliable, and we are not told whether the results are statistically significant (which makes me suspect they aren't). Finally, a low lipase in humans is associated with longstanding diseases and conditions that should not otherwise escape detection in any reasonably-designed study. Adam, I think it's a waste of all of our time to speculate about a study's results that has not been fully communicated -- at least provide an abstract for us, or the Web site -- or your subsequent thoughts which, as englishvet kindly pointed out, are not based in fact. I already told you my opinion concerning the flurry of initial research that aren't followed up by subsequent studies -- you just see it in rosacea but it's actually common in science, and usually indicates that subsequent work didn't pan out (unfortunately, few negative studies are published, so the absense of studies is often our only hint.) Marjorie Marjorie Lazoff, MD > I am assuming that the lipase levels you are referring to were > measured in blood. Marjorie is more qualified than me to comment on > the significance of reduced blood lipase levels in humans (if any). > > I will tell you that the pancreas is both an endocrine and exocrine > organ, that is it secretes both enzymes for digestion and hormones. > > A reduction in the production of digestive enzymes in dogs is called > Exocrine Pancreatic Insufficiency and results in an emaciated > appearance and chronic severe diarrhoea (due to undigested food making > it to the colon which, as you can imagine, makes the colonic flora > stand up and salute). > > In any case, I don't see why a reduced production of lipase would > result in an increase in postprandial lipaemia.........the opposite > would be true. Quote Link to comment Share on other sites More sharing options...
Guest guest Posted May 22, 2002 Report Share Posted May 22, 2002 I aplogise.. and you're right, I should've supplied an abstract with my Email. The last thing I wanna do here is waste everyone's time. My thought process as I wrote the Email was basically " this seems interesting, I wonder if anyone else has ever heard of this " Again I'm no doctor, so, maybe the percentage spread is unreliable, but the way it was written, I believe it means that some people had as little as 18% lipase reduction while others had as much as 66% lipase reduction.. It wasnt that somewhere between 18-66% of ceans suffered from this problem... When looking at it in this context (Sorry I wasn't more clear) it doesn't seem unreliable to me, because it could simply correlate to the severity of each patient's cea. Anyway, below is the name of the article and the abstract: Unfortunately with cea, I sometimes am concerned when I read these old articles that perhaps the lack of further research has nothing to do with an experiment not panning out, but simply a lack of funding. For instance, there was another article that was written in 1982 that discusses a misfunctioning hypothalimus in cea that causes the skin to overheat by trying too hard to cool down the brain.. (Or something along these lines, I dont really understand the human body, so I didn't understand the article completely) This has been mentioned many times since then, in Dr. Nase's book, a few times in this forum, and in a bunch of other articles and websites. However, as near as I can tell, no further studies have ever been undertaken that have attempted to prove or disprove this theory.. (But when half of the six yearly research studies taking place on cea are testing different formulations of Metronidazole... Its no surprise that there haven't been any major advances in a while..) Dermatologica 1982;165(6):601-6 Related Articles, Books, LinkOut Pancreatic exocrine function in rosacea. Barba A, B, Angelini G, Sapuppo A, Brocco G, Scuro LA, Cavallini G. As some rosacea patients complain of gastrointestinal troubles and the administration of pancreatic extracts ameliorates both dyspepsia and skin lesions, the pancreatic exocrine function in 21 subjects affected with rosacea has been investigated by means of the secretin-cerulein infusion test. 21 healthy controls have been studied for comparison. No difference was found between rosacea and control subjects for flow rate, bicarbonate and chymotrypsin concentration and output, while lipase concentration and output was significantly lower in rosacea patients, with a decrease ranging from 18.5 to 66% of normal values. Therefore, a deficient lipase secretion could be responsible, at least partly, for the clinical manifestations of rosacea. PMID: 6220929 [PubMed - indexed for MEDLINE] Re: Lipase and cea > > Englishtexvet, from what Adam has told us about the study, I'm far > from convinced it identified an association between low lipase levels > and rosacea. The percentage spread sounds unreliable, and we are not > told whether the results are statistically significant (which makes > me suspect they aren't). Finally, a low lipase in humans is > associated with longstanding diseases and conditions that should not > otherwise escape detection in any reasonably-designed study. > > Adam, I think it's a waste of all of our time to speculate about a > study's results that has not been fully communicated -- at least > provide an abstract for us, or the Web site -- or your subsequent > thoughts which, as englishvet kindly pointed out, are not based in > fact. > > I already told you my opinion concerning the flurry of initial > research that aren't followed up by subsequent studies -- you just > see it in rosacea but it's actually common in science, and usually > indicates that subsequent work didn't pan out (unfortunately, few > negative studies are published, so the absense of studies is often > our only hint.) > > Marjorie > > Marjorie Lazoff, MD > > > > > > I am assuming that the lipase levels you are referring to were > > measured in blood. Marjorie is more qualified than me to comment on > > the significance of reduced blood lipase levels in humans (if any). > > > > I will tell you that the pancreas is both an endocrine and exocrine > > organ, that is it secretes both enzymes for digestion and hormones. > > > > A reduction in the production of digestive enzymes in dogs is called > > Exocrine Pancreatic Insufficiency and results in an emaciated > > appearance and chronic severe diarrhoea (due to undigested food > making > > it to the colon which, as you can imagine, makes the colonic flora > > stand up and salute). > > > > In any case, I don't see why a reduced production of lipase would > > result in an increase in postprandial lipaemia.........the opposite > > would be true. > > > > -- > Please read the list highlights before posting to the whole group (http://rosacea.ii.net/toc.html). Your post will be delayed if you don't give a meaningful subject or trim your reply text. You must change the subject when replying to a digest ! > > See http://www.drnase.com for info on his recently published book. > > To leave the list send an email to rosacea-support-unsubscribe > > Quote Link to comment Share on other sites More sharing options...
Guest guest Posted May 22, 2002 Report Share Posted May 22, 2002 I aplogise.. and you're right, I should've supplied an abstract with my Email. The last thing I wanna do here is waste everyone's time. My thought process as I wrote the Email was basically " this seems interesting, I wonder if anyone else has ever heard of this " Again I'm no doctor, so, maybe the percentage spread is unreliable, but the way it was written, I believe it means that some people had as little as 18% lipase reduction while others had as much as 66% lipase reduction.. It wasnt that somewhere between 18-66% of ceans suffered from this problem... When looking at it in this context (Sorry I wasn't more clear) it doesn't seem unreliable to me, because it could simply correlate to the severity of each patient's cea. Anyway, below is the name of the article and the abstract: Unfortunately with cea, I sometimes am concerned when I read these old articles that perhaps the lack of further research has nothing to do with an experiment not panning out, but simply a lack of funding. For instance, there was another article that was written in 1982 that discusses a misfunctioning hypothalimus in cea that causes the skin to overheat by trying too hard to cool down the brain.. (Or something along these lines, I dont really understand the human body, so I didn't understand the article completely) This has been mentioned many times since then, in Dr. Nase's book, a few times in this forum, and in a bunch of other articles and websites. However, as near as I can tell, no further studies have ever been undertaken that have attempted to prove or disprove this theory.. (But when half of the six yearly research studies taking place on cea are testing different formulations of Metronidazole... Its no surprise that there haven't been any major advances in a while..) Dermatologica 1982;165(6):601-6 Related Articles, Books, LinkOut Pancreatic exocrine function in rosacea. Barba A, B, Angelini G, Sapuppo A, Brocco G, Scuro LA, Cavallini G. As some rosacea patients complain of gastrointestinal troubles and the administration of pancreatic extracts ameliorates both dyspepsia and skin lesions, the pancreatic exocrine function in 21 subjects affected with rosacea has been investigated by means of the secretin-cerulein infusion test. 21 healthy controls have been studied for comparison. No difference was found between rosacea and control subjects for flow rate, bicarbonate and chymotrypsin concentration and output, while lipase concentration and output was significantly lower in rosacea patients, with a decrease ranging from 18.5 to 66% of normal values. Therefore, a deficient lipase secretion could be responsible, at least partly, for the clinical manifestations of rosacea. PMID: 6220929 [PubMed - indexed for MEDLINE] Re: Lipase and cea > > Englishtexvet, from what Adam has told us about the study, I'm far > from convinced it identified an association between low lipase levels > and rosacea. The percentage spread sounds unreliable, and we are not > told whether the results are statistically significant (which makes > me suspect they aren't). Finally, a low lipase in humans is > associated with longstanding diseases and conditions that should not > otherwise escape detection in any reasonably-designed study. > > Adam, I think it's a waste of all of our time to speculate about a > study's results that has not been fully communicated -- at least > provide an abstract for us, or the Web site -- or your subsequent > thoughts which, as englishvet kindly pointed out, are not based in > fact. > > I already told you my opinion concerning the flurry of initial > research that aren't followed up by subsequent studies -- you just > see it in rosacea but it's actually common in science, and usually > indicates that subsequent work didn't pan out (unfortunately, few > negative studies are published, so the absense of studies is often > our only hint.) > > Marjorie > > Marjorie Lazoff, MD > > > > > > I am assuming that the lipase levels you are referring to were > > measured in blood. Marjorie is more qualified than me to comment on > > the significance of reduced blood lipase levels in humans (if any). > > > > I will tell you that the pancreas is both an endocrine and exocrine > > organ, that is it secretes both enzymes for digestion and hormones. > > > > A reduction in the production of digestive enzymes in dogs is called > > Exocrine Pancreatic Insufficiency and results in an emaciated > > appearance and chronic severe diarrhoea (due to undigested food > making > > it to the colon which, as you can imagine, makes the colonic flora > > stand up and salute). > > > > In any case, I don't see why a reduced production of lipase would > > result in an increase in postprandial lipaemia.........the opposite > > would be true. > > > > -- > Please read the list highlights before posting to the whole group (http://rosacea.ii.net/toc.html). Your post will be delayed if you don't give a meaningful subject or trim your reply text. You must change the subject when replying to a digest ! > > See http://www.drnase.com for info on his recently published book. > > To leave the list send an email to rosacea-support-unsubscribe > > Quote Link to comment Share on other sites More sharing options...
Guest guest Posted May 22, 2002 Report Share Posted May 22, 2002 > > > I am assuming that the lipase levels you are referring to were > > > measured in blood. Marjorie is more qualified than me to comment on > > > the significance of reduced blood lipase levels in humans (if any). > > > > > > I will tell you that the pancreas is both an endocrine and exocrine > > > organ, that is it secretes both enzymes for digestion and hormones. > > > > > > A reduction in the production of digestive enzymes in dogs is called > > > Exocrine Pancreatic Insufficiency and results in an emaciated > > > appearance and chronic severe diarrhoea (due to undigested food > > making > > > it to the colon which, as you can imagine, makes the colonic flora > > > stand up and salute). > > > > > > In any case, I don't see why a reduced production of lipase would > > > result in an increase in postprandial lipaemia.........the opposite > > > would be true. > > > > > > > > -- > > Please read the list highlights before posting to the whole group > (http://rosacea.ii.net/toc.html). Your post will be delayed if you don't > give a meaningful subject or trim your reply text. You must change the > subject when replying to a digest ! > > > > See http://www.drnase.com for info on his recently published book. > > > > To leave the list send an email to > rosacea-support-unsubscribe@y... > > > > Quote Link to comment Share on other sites More sharing options...
Guest guest Posted May 22, 2002 Report Share Posted May 22, 2002 > > > I am assuming that the lipase levels you are referring to were > > > measured in blood. Marjorie is more qualified than me to comment on > > > the significance of reduced blood lipase levels in humans (if any). > > > > > > I will tell you that the pancreas is both an endocrine and exocrine > > > organ, that is it secretes both enzymes for digestion and hormones. > > > > > > A reduction in the production of digestive enzymes in dogs is called > > > Exocrine Pancreatic Insufficiency and results in an emaciated > > > appearance and chronic severe diarrhoea (due to undigested food > > making > > > it to the colon which, as you can imagine, makes the colonic flora > > > stand up and salute). > > > > > > In any case, I don't see why a reduced production of lipase would > > > result in an increase in postprandial lipaemia.........the opposite > > > would be true. > > > > > > > > -- > > Please read the list highlights before posting to the whole group > (http://rosacea.ii.net/toc.html). Your post will be delayed if you don't > give a meaningful subject or trim your reply text. You must change the > subject when replying to a digest ! > > > > See http://www.drnase.com for info on his recently published book. > > > > To leave the list send an email to > rosacea-support-unsubscribe@y... > > > > Quote Link to comment Share on other sites More sharing options...
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