Re: Lipase and cea

[Guest guest]

Englishtexvet, from what Adam has told us about the study, I'm far

from convinced it identified an association between low lipase levels

and rosacea. The percentage spread sounds unreliable, and we are not

told whether the results are statistically significant (which makes

me suspect they aren't). Finally, a low lipase in humans is

associated with longstanding diseases and conditions that should not

otherwise escape detection in any reasonably-designed study.

Adam, I think it's a waste of all of our time to speculate about a

study's results that has not been fully communicated -- at least

provide an abstract for us, or the Web site -- or your subsequent

thoughts which, as englishvet kindly pointed out, are not based in

fact.

I already told you my opinion concerning the flurry of initial

research that aren't followed up by subsequent studies -- you just

see it in rosacea but it's actually common in science, and usually

indicates that subsequent work didn't pan out (unfortunately, few

negative studies are published, so the absense of studies is often

our only hint.)

Marjorie

Marjorie Lazoff, MD

> I am assuming that the lipase levels you are referring to were

> measured in blood. Marjorie is more qualified than me to comment on

> the significance of reduced blood lipase levels in humans (if any).

>

> I will tell you that the pancreas is both an endocrine and exocrine

> organ, that is it secretes both enzymes for digestion and hormones.

>

> A reduction in the production of digestive enzymes in dogs is called

> Exocrine Pancreatic Insufficiency and results in an emaciated

> appearance and chronic severe diarrhoea (due to undigested food

making

> it to the colon which, as you can imagine, makes the colonic flora

> stand up and salute).

>

> In any case, I don't see why a reduced production of lipase would

> result in an increase in postprandial lipaemia.........the opposite

> would be true.