Guest guest Posted May 14, 2002 Report Share Posted May 14, 2002 Barry, do you know why it won't be available in the US for some time? Here's the marketing blurb on Mexoryl: http://www.lorealusa.com/frameset.asp?research/mexoryl.asp Marjorie Marjorie Lazoff, MD > Mexoryl SX is " terephtalylidene dicamphor sulfonic acid " patented by L'Oreal > (what hasn't been patented by L'Oreal!!!). It's a broad spectrum UVA > absorber, and probably won't be available in the USA for some time. The > nearest equivalent in US products is probably Avobenzone. > > Barry Hunt Quote Link to comment Share on other sites More sharing options...
Guest guest Posted May 14, 2002 Report Share Posted May 14, 2002 Barry, do you know why it won't be available in the US for some time? Here's the marketing blurb on Mexoryl: http://www.lorealusa.com/frameset.asp?research/mexoryl.asp Marjorie Marjorie Lazoff, MD > Mexoryl SX is " terephtalylidene dicamphor sulfonic acid " patented by L'Oreal > (what hasn't been patented by L'Oreal!!!). It's a broad spectrum UVA > absorber, and probably won't be available in the USA for some time. The > nearest equivalent in US products is probably Avobenzone. > > Barry Hunt Quote Link to comment Share on other sites More sharing options...
Guest guest Posted May 14, 2002 Report Share Posted May 14, 2002 Barry, do you know why it won't be available in the US for some time? Here's the marketing blurb on Mexoryl: http://www.lorealusa.com/frameset.asp?research/mexoryl.asp Marjorie Marjorie Lazoff, MD > Mexoryl SX is " terephtalylidene dicamphor sulfonic acid " patented by L'Oreal > (what hasn't been patented by L'Oreal!!!). It's a broad spectrum UVA > absorber, and probably won't be available in the USA for some time. The > nearest equivalent in US products is probably Avobenzone. > > Barry Hunt Quote Link to comment Share on other sites More sharing options...
Guest guest Posted May 14, 2002 Report Share Posted May 14, 2002 As I understand it, someone has to attempt to register a sunscreen product containing the " new drug " with the FDA, who then demand enormous amounts of information (and equally large amounts of money) to approve the product with the new ingredient. This takes some time - normally years - so unless someone like L'Oreal have got something under way it may be some time before it is on the supermarket shelf. Once the first product has been approved with the new ingredient it is easier for any future products. I'm not an expert at the registration process but I think the above is correct. regards Barry Re: Mexoryl® Barry, do you know why it won't be available in the US for some time? Here's the marketing blurb on Mexoryl: http://www.lorealusa.com/frameset.asp?research/mexoryl.asp Marjorie Marjorie Lazoff, MD > Mexoryl SX is " terephtalylidene dicamphor sulfonic acid " patented by L'Oreal > (what hasn't been patented by L'Oreal!!!). It's a broad spectrum UVA > absorber, and probably won't be available in the USA for some time. The > nearest equivalent in US products is probably Avobenzone. > > Barry Hunt -- Please read the list highlights before posting to the whole group (http://rosacea.ii.net/toc.html). Your post will be delayed if you don't give a meaningful subject or trim your reply text. You must change the subject when replying to a digest ! See http://www.drnase.com for info on his recently published book. To leave the list send an email to rosacea-support-unsubscribe Quote Link to comment Share on other sites More sharing options...
Guest guest Posted May 14, 2002 Report Share Posted May 14, 2002 As I understand it, someone has to attempt to register a sunscreen product containing the " new drug " with the FDA, who then demand enormous amounts of information (and equally large amounts of money) to approve the product with the new ingredient. This takes some time - normally years - so unless someone like L'Oreal have got something under way it may be some time before it is on the supermarket shelf. Once the first product has been approved with the new ingredient it is easier for any future products. I'm not an expert at the registration process but I think the above is correct. regards Barry Re: Mexoryl® Barry, do you know why it won't be available in the US for some time? Here's the marketing blurb on Mexoryl: http://www.lorealusa.com/frameset.asp?research/mexoryl.asp Marjorie Marjorie Lazoff, MD > Mexoryl SX is " terephtalylidene dicamphor sulfonic acid " patented by L'Oreal > (what hasn't been patented by L'Oreal!!!). It's a broad spectrum UVA > absorber, and probably won't be available in the USA for some time. The > nearest equivalent in US products is probably Avobenzone. > > Barry Hunt -- Please read the list highlights before posting to the whole group (http://rosacea.ii.net/toc.html). Your post will be delayed if you don't give a meaningful subject or trim your reply text. You must change the subject when replying to a digest ! See http://www.drnase.com for info on his recently published book. To leave the list send an email to rosacea-support-unsubscribe Quote Link to comment Share on other sites More sharing options...
Guest guest Posted May 14, 2002 Report Share Posted May 14, 2002 As I understand it, someone has to attempt to register a sunscreen product containing the " new drug " with the FDA, who then demand enormous amounts of information (and equally large amounts of money) to approve the product with the new ingredient. This takes some time - normally years - so unless someone like L'Oreal have got something under way it may be some time before it is on the supermarket shelf. Once the first product has been approved with the new ingredient it is easier for any future products. I'm not an expert at the registration process but I think the above is correct. regards Barry Re: Mexoryl® Barry, do you know why it won't be available in the US for some time? Here's the marketing blurb on Mexoryl: http://www.lorealusa.com/frameset.asp?research/mexoryl.asp Marjorie Marjorie Lazoff, MD > Mexoryl SX is " terephtalylidene dicamphor sulfonic acid " patented by L'Oreal > (what hasn't been patented by L'Oreal!!!). It's a broad spectrum UVA > absorber, and probably won't be available in the USA for some time. The > nearest equivalent in US products is probably Avobenzone. > > Barry Hunt -- Please read the list highlights before posting to the whole group (http://rosacea.ii.net/toc.html). Your post will be delayed if you don't give a meaningful subject or trim your reply text. You must change the subject when replying to a digest ! See http://www.drnase.com for info on his recently published book. To leave the list send an email to rosacea-support-unsubscribe Quote Link to comment Share on other sites More sharing options...
Guest guest Posted May 15, 2002 Report Share Posted May 15, 2002 Makes sense, Barry, thanks. The site says that, " Mexoryl SX has been patented by L'Oréal, and has been used in the Group's sunscreen formulations in Europe since 1993. Research activities are underway to develop products that can be introduced to the US market. " Ten years sounds like a long time. There could be many reasons, of course, but it makes me wonder if that Canadian pharmacist was correct, that the company (L'Oreal) is having problems proving its claim of photostability to the FDA. I don't know. But even if photostable, it's still absorbed into the skin, which makes it potentially irritating like other sunscreen (as opposed to inert sunblock) agents. Plus, the combined metronidazole-mexoryl product would have to be applied all over the face and in sufficient amounts to protect from the sun. At present, I apply metronidazole to just my cheeks and nose, in very small amounts, I don't believe my skin would tolerate a full-metronidazole assault. I like the idea of saving a step, of combining topical anti- inflammatory agents with sun protection, but I think something like ZincO (a sunblock that is itself anti-inflammatory) is a better approach than a combination product. (Not for me, though, I can't tolerate ZincO. I need Dr. Sy to create Titanium DiO. ) From one non-expert to another, Marjorie Marjorie Lazoff, MD > As I understand it, someone has to attempt to register a sunscreen product > containing the " new drug " with the FDA, who then demand enormous amounts of > information (and equally large amounts of money) to approve the product with > the new ingredient. This takes some time - normally years - so unless > someone like L'Oreal have got something under way it may be some time before > it is on the supermarket shelf. > > Once the first product has been approved with the new ingredient it is > easier for any future products. > > I'm not an expert at the registration process but I think the above is > correct. > > regards > > Barry > > Re: Mexoryl® > > > > Barry, do you know why it won't be available in the US for some time? > > Here's the marketing blurb on Mexoryl: > > http://www.lorealusa.com/frameset.asp?research/mexoryl.asp > > > Marjorie > > Marjorie Lazoff, MD > > > Mexoryl SX is " terephtalylidene dicamphor sulfonic acid " patented > by L'Oreal > > (what hasn't been patented by L'Oreal!!!). It's a broad spectrum UVA > > absorber, and probably won't be available in the USA for some time. > The > > nearest equivalent in US products is probably Avobenzone. > > > > Barry Hunt > > > > -- > Please read the list highlights before posting to the whole group > (http://rosacea.ii.net/toc.html). Your post will be delayed if you don't > give a meaningful subject or trim your reply text. You must change the > subject when replying to a digest ! > > See http://www.drnase.com for info on his recently published book. > > To leave the list send an email to > rosacea-support-unsubscribe@y... > > Quote Link to comment Share on other sites More sharing options...
Guest guest Posted May 15, 2002 Report Share Posted May 15, 2002 The idea of metronidazole combined with sun protection is interesting, though it makes me wonder about the practicality of such product. Recently, I read in a magazine (and it's not the first time I read this) that sunscreen is to be applied in liberal amounts all over the face, the neck and the ears. In fact, the article mentioned that the amount of sunscreen to be used for a single application should be equal to 2 tablespoons. It sounds excessive to me and I wonder if anyone else uses this much?? (please fess up). I hate sunscreens (and cannot find one that doesn't make me break out) so I am dabbing it very carefully on my face and I know I am not using nearly enough. Anyway, my point was do we want to apply metronidazole on the neck and ears as well? Or if it's meant to be used on the face only, then we still need another (unmedicated) sunscreen lotion for those areas. A different topic: Since I am posting, I will also mention that I cornered about a month ago (well, it was a virtual corner ) and she sent me the outline of her diet, which I have followed since. I dropped wheat & white flour, dairy, sugar, and limited the consumption of carbs, and increased consumption of fruit and veggies and fish fish fish. I do have an ocassional serving of something from the excluded items, but those are exceptions. I drink gallons of water. My condition was not as bad as 's, and my diet is not as strict as hers, so I cannot report that it had huge impact on my face, but I am doing ok. I lost weight, and I had to get myself a smaller size of jeans (that's what I call happy shopping). When I got to the store, I found out that my usual brand (Levi's) is on sale, so I got myself two pairs. Well, as soon as I started to wear the first pair, I discovered it is still a bit loose - so I went back to exchange the second pair for a yet smaller size (which I am not wearing yet but will be soon!) :-) My flushes are milder (so I called them blushes now) and the redness/pinkness is in general my only problem. I stopped using Metrogel because it gave me little pimples in the areas where my skin is oily (nasolabial fold, the nose, between the eyebrows, the forehead). So now I use HerbaCort only, and of course, cabbage every night. I use Neutrogena SPF 15 for going outside with the dogs or some gardening, but I wash it off as soon as I am back home. The HerbaCort is almost used up (it stretched to 5 wks which really exceeded my original expectation) and since I am quite stable now I am thinking of trying something new .... maybe Oil of Olay with niacinamide or Gold Bond. I will keep you posted. Best wishes to everyone, Alena Quote Link to comment Share on other sites More sharing options...
Guest guest Posted May 15, 2002 Report Share Posted May 15, 2002 The idea of metronidazole combined with sun protection is interesting, though it makes me wonder about the practicality of such product. Recently, I read in a magazine (and it's not the first time I read this) that sunscreen is to be applied in liberal amounts all over the face, the neck and the ears. In fact, the article mentioned that the amount of sunscreen to be used for a single application should be equal to 2 tablespoons. It sounds excessive to me and I wonder if anyone else uses this much?? (please fess up). I hate sunscreens (and cannot find one that doesn't make me break out) so I am dabbing it very carefully on my face and I know I am not using nearly enough. Anyway, my point was do we want to apply metronidazole on the neck and ears as well? Or if it's meant to be used on the face only, then we still need another (unmedicated) sunscreen lotion for those areas. A different topic: Since I am posting, I will also mention that I cornered about a month ago (well, it was a virtual corner ) and she sent me the outline of her diet, which I have followed since. I dropped wheat & white flour, dairy, sugar, and limited the consumption of carbs, and increased consumption of fruit and veggies and fish fish fish. I do have an ocassional serving of something from the excluded items, but those are exceptions. I drink gallons of water. My condition was not as bad as 's, and my diet is not as strict as hers, so I cannot report that it had huge impact on my face, but I am doing ok. I lost weight, and I had to get myself a smaller size of jeans (that's what I call happy shopping). When I got to the store, I found out that my usual brand (Levi's) is on sale, so I got myself two pairs. Well, as soon as I started to wear the first pair, I discovered it is still a bit loose - so I went back to exchange the second pair for a yet smaller size (which I am not wearing yet but will be soon!) :-) My flushes are milder (so I called them blushes now) and the redness/pinkness is in general my only problem. I stopped using Metrogel because it gave me little pimples in the areas where my skin is oily (nasolabial fold, the nose, between the eyebrows, the forehead). So now I use HerbaCort only, and of course, cabbage every night. I use Neutrogena SPF 15 for going outside with the dogs or some gardening, but I wash it off as soon as I am back home. The HerbaCort is almost used up (it stretched to 5 wks which really exceeded my original expectation) and since I am quite stable now I am thinking of trying something new .... maybe Oil of Olay with niacinamide or Gold Bond. I will keep you posted. Best wishes to everyone, Alena Quote Link to comment Share on other sites More sharing options...
Guest guest Posted May 15, 2002 Report Share Posted May 15, 2002 The idea of metronidazole combined with sun protection is interesting, though it makes me wonder about the practicality of such product. Recently, I read in a magazine (and it's not the first time I read this) that sunscreen is to be applied in liberal amounts all over the face, the neck and the ears. In fact, the article mentioned that the amount of sunscreen to be used for a single application should be equal to 2 tablespoons. It sounds excessive to me and I wonder if anyone else uses this much?? (please fess up). I hate sunscreens (and cannot find one that doesn't make me break out) so I am dabbing it very carefully on my face and I know I am not using nearly enough. Anyway, my point was do we want to apply metronidazole on the neck and ears as well? Or if it's meant to be used on the face only, then we still need another (unmedicated) sunscreen lotion for those areas. A different topic: Since I am posting, I will also mention that I cornered about a month ago (well, it was a virtual corner ) and she sent me the outline of her diet, which I have followed since. I dropped wheat & white flour, dairy, sugar, and limited the consumption of carbs, and increased consumption of fruit and veggies and fish fish fish. I do have an ocassional serving of something from the excluded items, but those are exceptions. I drink gallons of water. My condition was not as bad as 's, and my diet is not as strict as hers, so I cannot report that it had huge impact on my face, but I am doing ok. I lost weight, and I had to get myself a smaller size of jeans (that's what I call happy shopping). When I got to the store, I found out that my usual brand (Levi's) is on sale, so I got myself two pairs. Well, as soon as I started to wear the first pair, I discovered it is still a bit loose - so I went back to exchange the second pair for a yet smaller size (which I am not wearing yet but will be soon!) :-) My flushes are milder (so I called them blushes now) and the redness/pinkness is in general my only problem. I stopped using Metrogel because it gave me little pimples in the areas where my skin is oily (nasolabial fold, the nose, between the eyebrows, the forehead). So now I use HerbaCort only, and of course, cabbage every night. I use Neutrogena SPF 15 for going outside with the dogs or some gardening, but I wash it off as soon as I am back home. The HerbaCort is almost used up (it stretched to 5 wks which really exceeded my original expectation) and since I am quite stable now I am thinking of trying something new .... maybe Oil of Olay with niacinamide or Gold Bond. I will keep you posted. Best wishes to everyone, Alena Quote Link to comment Share on other sites More sharing options...
Guest guest Posted May 15, 2002 Report Share Posted May 15, 2002 Re: Re: Mexoryl® The idea of metronidazole combined with sun protection is interesting, though it makes me wonder about the practicality of such product. Recently, I read in a magazine (and it's not the first time I read this) that sunscreen is to be applied in liberal amounts all over the face, the neck and the ears. In fact, the article mentioned that the amount of sunscreen to be used for a single application should be equal to 2 tablespoons. It sounds excessive to me and I wonder if anyone else uses this much?? (please fess up). I agree! Nobody uses the " full " amount of sunscreen. I'm involved slightly with the sunscreen industry here in Australia and I've argued that the test for SPF should be changed to represent what people really use. This isn't going to happen in the foreseeable future! There's certainly a conflict in my mind about combining two products, one of which is for slapping on liberally all over, and the other for use sparingly, and only where needed. Barry Hunt Quote Link to comment Share on other sites More sharing options...
Guest guest Posted May 15, 2002 Report Share Posted May 15, 2002 Re: Re: Mexoryl® The idea of metronidazole combined with sun protection is interesting, though it makes me wonder about the practicality of such product. Recently, I read in a magazine (and it's not the first time I read this) that sunscreen is to be applied in liberal amounts all over the face, the neck and the ears. In fact, the article mentioned that the amount of sunscreen to be used for a single application should be equal to 2 tablespoons. It sounds excessive to me and I wonder if anyone else uses this much?? (please fess up). I agree! Nobody uses the " full " amount of sunscreen. I'm involved slightly with the sunscreen industry here in Australia and I've argued that the test for SPF should be changed to represent what people really use. This isn't going to happen in the foreseeable future! There's certainly a conflict in my mind about combining two products, one of which is for slapping on liberally all over, and the other for use sparingly, and only where needed. Barry Hunt Quote Link to comment Share on other sites More sharing options...
Guest guest Posted May 15, 2002 Report Share Posted May 15, 2002 Re: Re: Mexoryl® The idea of metronidazole combined with sun protection is interesting, though it makes me wonder about the practicality of such product. Recently, I read in a magazine (and it's not the first time I read this) that sunscreen is to be applied in liberal amounts all over the face, the neck and the ears. In fact, the article mentioned that the amount of sunscreen to be used for a single application should be equal to 2 tablespoons. It sounds excessive to me and I wonder if anyone else uses this much?? (please fess up). I agree! Nobody uses the " full " amount of sunscreen. I'm involved slightly with the sunscreen industry here in Australia and I've argued that the test for SPF should be changed to represent what people really use. This isn't going to happen in the foreseeable future! There's certainly a conflict in my mind about combining two products, one of which is for slapping on liberally all over, and the other for use sparingly, and only where needed. Barry Hunt Quote Link to comment Share on other sites More sharing options...
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