Guest guest Posted May 15, 2002 Report Share Posted May 15, 2002 Makes sense, Barry, thanks. The site says that, " Mexoryl SX has been patented by L'Oréal, and has been used in the Group's sunscreen formulations in Europe since 1993. Research activities are underway to develop products that can be introduced to the US market. " Ten years sounds like a long time. There could be many reasons, of course, but it makes me wonder if that Canadian pharmacist was correct, that the company (L'Oreal) is having problems proving its claim of photostability to the FDA. I don't know. But even if photostable, it's still absorbed into the skin, which makes it potentially irritating like other sunscreen (as opposed to inert sunblock) agents. Plus, the combined metronidazole-mexoryl product would have to be applied all over the face and in sufficient amounts to protect from the sun. At present, I apply metronidazole to just my cheeks and nose, in very small amounts, I don't believe my skin would tolerate a full-metronidazole assault. I like the idea of saving a step, of combining topical anti- inflammatory agents with sun protection, but I think something like ZincO (a sunblock that is itself anti-inflammatory) is a better approach than a combination product. (Not for me, though, I can't tolerate ZincO. I need Dr. Sy to create Titanium DiO. ) From one non-expert to another, Marjorie Marjorie Lazoff, MD > As I understand it, someone has to attempt to register a sunscreen product > containing the " new drug " with the FDA, who then demand enormous amounts of > information (and equally large amounts of money) to approve the product with > the new ingredient. This takes some time - normally years - so unless > someone like L'Oreal have got something under way it may be some time before > it is on the supermarket shelf. > > Once the first product has been approved with the new ingredient it is > easier for any future products. > > I'm not an expert at the registration process but I think the above is > correct. > > regards > > Barry > > Re: Mexoryl® > > > > Barry, do you know why it won't be available in the US for some time? > > Here's the marketing blurb on Mexoryl: > > http://www.lorealusa.com/frameset.asp?research/mexoryl.asp > > > Marjorie > > Marjorie Lazoff, MD > > > Mexoryl SX is " terephtalylidene dicamphor sulfonic acid " patented > by L'Oreal > > (what hasn't been patented by L'Oreal!!!). It's a broad spectrum UVA > > absorber, and probably won't be available in the USA for some time. > The > > nearest equivalent in US products is probably Avobenzone. > > > > Barry Hunt > > > > -- > Please read the list highlights before posting to the whole group > (http://rosacea.ii.net/toc.html). Your post will be delayed if you don't > give a meaningful subject or trim your reply text. You must change the > subject when replying to a digest ! > > See http://www.drnase.com for info on his recently published book. > > To leave the list send an email to > rosacea-support-unsubscribe@y... > > Quote Link to comment Share on other sites More sharing options...
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