Re: Accutane (was Wellbutrin SR and cea)

April 30, 2002

> > I think its pretty absurd to be on psyshiatric medications for a

> > treatable skin condition. The answer to the problem lies in

fixing

> > the fixable skin. Did you try accutane 10 mg qod?

> >

April 30, 2002

This is a very good question you ask. Clearly, Accutane is

responsible for some people's cases of rosacea. Recall some of my

previous posts wherein they referenced non rosaceans on full dose

accutane. They are not rosacea flushed. However, a too high

Accutane dose will cause a rosacea flush in a rosacean or pre

rosacean. Certainly, full dose courses of accutane can cause

rosacea, and if fact have. The benefit of the full dose accutane is

that it is done in 15 - 20 weeks, and usually there is a permanent

acne cure. Sure, it's a tough 5 months, but once you're done, you're

done. If a rosacean were to do 5 months of accutane it would be more

than a tough 5 months. It would be disaster beyond your wildest

imagination. The worse rosacea flare ever.

Now, I'm not one to advocate suffering. Even if suffering can bring

out a benefit. There is a better way. It turns out that Accutane

does have great anti-inflammatory effects. But only at a low dose.

In fact, it is used to treat blephartis in ocular rosacea, but only

at a dose of 10 mg qod. It is used to treat steroid acne. Which is

the cousin disease to steroid rosacea. But only at 5 mg qod. It

should be noted that steroid acne starts out without comedones. At

5mg/d, the pustulation effects of accutane are minimized, but the

anti-inflammatory effects are maximized. This is exactly what

rosaceans want. I used to advocate 10 mg /d. But over several

months this becomes to much. Now I advoate starting at 10 mg qod and

just sitting back and waiting for the results to occur.

Think of it this way, in terms of side effects. The RDA for Vitamin

is is about 1 to 3 mg /d. Accutane is a synthetic form of vitamin A

but with anti-inflammatory properties in the skin, and it also

changes the composition of sebum so that it contains more linolenic

fatty acid, thus reducing the formation of microcomedones. It also

normalizes keratinization. At higher doses, this is seen as

pustulation, as the comedones are rapidly expelled outwards thorugh

the follicular canal, clearing the follicle. Too many comedones, and

you will flare when this happens. Therefore, at the 5 mg/d dose,

things go very smoothly and slowly, there is no flare, only

improvement, and blood flow to the face is lessened and facial

temperature reduced.

In keeping with the RDA of vitamin a analogy, 5 mg/d is about what

the body is expected to handle every day. so, there is no toxicity.

Plus, if you have ocular rosacea, you will get that treated as well.

The only reason for higher dose accutane is for rhynophyma. But if

you start out on the 5mg/d dose, you will never get rhynphyma, and

things will be much better for you.

After several months you will note the effects of the 5mg/d accutane

and it should work. There is a study noting great improvement on

10mg/d starting with significant improvement from weeks 9 onward, so

there is evidence out there. The best thing is to do it and see how

good it is.

> > I think its pretty absurd to be on psyshiatric medications for a

> > treatable skin condition. The answer to the problem lies in

fixing

> > the fixable skin. Did you try accutane 10 mg qod?

> >

April 30, 2002

I am on 5 mgs/day of Roaccutane for pustular rosacea - nasty painful pustules

that feel like thorns in the face. They oozed pus for up to three days after

they ripened and then took ages to heal. They were large swellings about 1.5

cms diameter, very red and shiny from the build up of pus pressure inside. I

was put on the low dose of 5 mgs/day nearly 8 weeks ago and I'm completely clear

of the pustules now and my face is the best it's been in two years.

Now for the downside. I was told that I will have to remain on this low dose

permanently as the condition will return if I stop. I have no side effects (so

far) other than a little dryness on the lips. I have been prescribed six months

supply and will see the derm again in six months. If there was a 2.5 mgs capsule

I suspect that might even have done the trick for me. Being male I do not have

to worry about birth control while on Roaccutane but there is some research

into low dose that suggest there is a possibility of acquiring DISH (bone

changes).

I also saw on a report that a long term low dose of Accutane/Roaccutane should

not exceed 7.5 mgs total per day and I nearly always read about low doses of

10 mgs/day being given for rosacea.

Someone asked about where they can find the 5 mgs size. This is available in

Europe but not I believe in the USA.

I posted a message about my logging daily the number of new pustules after I

started on the low dose Roaccutane and it shows how really fast the drug worked

for me. It's now 18 days since my last new pustule and my skin is really smooth,

clean and it is also dry compared with a very oily condition eight weeks ago.

If interested check it out under " kevciol " in the search box.

Some people have had a bad experience on Accutane/Roaccutane and the drug gets

a bad press as a result. All the millions who are cured of acne and who have

had relief from rosacea seem to keep quiet and not shout from the rooftops.

>This is a very good question you ask. Clearly, Accutane is

>responsible for some people's cases of rosacea. Recall some of my

>previous posts wherein they referenced non rosaceans on full dose

>accutane. They are not rosacea flushed. However, a too high

>Accutane dose will cause a rosacea flush in a rosacean or pre

>rosacean. Certainly, full dose courses of accutane can cause

>rosacea, and if fact have. The benefit of the full dose accutane is

>that it is done in 15 - 20 weeks, and usually there is a permanent

>acne cure. Sure, it's a tough 5 months, but once you're done, you're

>done. If a rosacean were to do 5 months of accutane it would be more

>than a tough 5 months. It would be disaster beyond your wildest

>imagination. The worse rosacea flare ever.

>

>Now, I'm not one to advocate suffering. Even if suffering can bring

>out a benefit. There is a better way. It turns out that Accutane

>does have great anti-inflammatory effects. But only at a low dose.

>In fact, it is used to treat blephartis in ocular rosacea, but only

>at a dose of 10 mg qod. It is used to treat steroid acne. Which is

>the cousin disease to steroid rosacea. But only at 5 mg qod. It

>should be noted that steroid acne starts out without comedones. At

>5mg/d, the pustulation effects of accutane are minimized, but the

>anti-inflammatory effects are maximized. This is exactly what

>rosaceans want. I used to advocate 10 mg /d. But over several

>months this becomes to much. Now I advoate starting at 10 mg qod and

>just sitting back and waiting for the results to occur.

>

>Think of it this way, in terms of side effects. The RDA for Vitamin

>is is about 1 to 3 mg /d. Accutane is a synthetic form of vitamin A

>but with anti-inflammatory properties in the skin, and it also

>changes the composition of sebum so that it contains more linolenic

>fatty acid, thus reducing the formation of microcomedones. It also

>normalizes keratinization. At higher doses, this is seen as

>pustulation, as the comedones are rapidly expelled outwards thorugh

>the follicular canal, clearing the follicle. Too many comedones, and

>you will flare when this happens. Therefore, at the 5 mg/d dose,

>things go very smoothly and slowly, there is no flare, only

>improvement, and blood flow to the face is lessened and facial

>temperature reduced.

>

>In keeping with the RDA of vitamin a analogy, 5 mg/d is about what

>the body is expected to handle every day. so, there is no toxicity.

>

>Plus, if you have ocular rosacea, you will get that treated as well.

>The only reason for higher dose accutane is for rhynophyma. But if

>you start out on the 5mg/d dose, you will never get rhynphyma, and

>things will be much better for you.

>

>After several months you will note the effects of the 5mg/d accutane

>and it should work. There is a study noting great improvement on

>10mg/d starting with significant improvement from weeks 9 onward, so

>there is evidence out there. The best thing is to do it and see how

>good it is.

>

>> > I think its pretty absurd to be on psyshiatric medications for a

>> > treatable skin condition. The answer to the problem lies in

>fixing

>> > the fixable skin. Did you try accutane 10 mg qod?

>> >

>

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>

>See http://www.drnase.com for info on his recently published book.

>

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>

April 30, 2002