Guest guest Posted June 4, 2002 Report Share Posted June 4, 2002 I looked into the IMPACs I mentioned in my last post a little bit more. I found some info on two of them that seemed interesting. The first is called CMT-8. It has been shown to inhibit TNF-(alpha). TNF-(alpha) makes the skin more receptive to VEGF, and in the Fall of 2001, the NRS began a study to see if inhibiting TNF-(alpha) might inhibit cea development. I'm not sure if the study is finished yet. I guess I would assume that if it is, and we haven't heard anything, that it was a bust.. but.. this is their second year studying VEGF so obviously they found something promising about it the first time... so.. hopefully the study just isnt finished yet.. It also reduces blood levels of serum fructosamine, prostaglandin E2 and nitric oxide. This was all done at concentrations which could be delivered without toxicity in animal models. I think these are very early on in development and so far have only been tested in rats. The other was CMT-3 which inhibits the invasion of Candida albicans Quote Link to comment Share on other sites More sharing options...
Guest guest Posted June 4, 2002 Report Share Posted June 4, 2002 , thanks for your generous offer. I already have the electronic version of the article, that's not the problem. I should have been clearer: the problem is that it isn't legal for anyone to post a copyrighted article directly on a public Web site without permission from the publisher. It's not something we normally think about in academia since we have implied permission to hardcopy articles for educational purposes. But that doesn't apply to freely distributing an article on the Web. I thought you might know where we could get a copy from another Web site (since it's OK for us to link to it, and probably even copy/paste it, if it's already freely available on the Web), or a comparable article that we could legally post here. Marjorie Marjorie Lazoff, MD > > > > I looked into the IMPACs I mentioned in my last post a little > bit > > > > more. I found some info on two of them that seemed interesting. > > > > > > > > The first is called CMT-8. It has been shown to inhibit > > > > TNF-(alpha). TNF-(alpha) makes the skin more receptive to VEGF, > > > > and in the Fall of 2001, the NRS began a study to see if > > > > inhibiting TNF-(alpha) might inhibit cea development. I'm > > > > not sure if the study is finished yet. I guess I would assume > > > > that if it is, and we haven't heard anything, that it was a > > > > bust.. but.. this is their second year studying VEGF so > obviously > > > > they found something promising about it the first time... so.. > > > > hopefully the study just isnt finished yet.. > > > > > > > > It also reduces blood levels of serum fructosamine, > prostaglandin > > > > E2 and nitric oxide. This was all done at concentrations which > > > > could be delivered without toxicity in animal models. I think > > > > these are very early on in development and so far have only been > > > > tested in rats. > > > > > > > > The other was CMT-3 which inhibits the invasion of Candida > > > > albicans > > > > > > > > > > > > Quote Link to comment Share on other sites More sharing options...
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