Guest guest Posted June 4, 2002 Report Share Posted June 4, 2002 I looked into the IMPACs I mentioned in my last post a little bit more. I found some info on two of them that seemed interesting. The first is called CMT-8. It has been shown to inhibit TNF-(alpha). TNF-(alpha) makes the skin more receptive to VEGF, and in the Fall of 2001, the NRS began a study to see if inhibiting TNF-(alpha) might inhibit cea development. I'm not sure if the study is finished yet. I guess I would assume that if it is, and we haven't heard anything, that it was a bust.. but.. this is their second year studying VEGF so obviously they found something promising about it the first time... so.. hopefully the study just isnt finished yet.. It also reduces blood levels of serum fructosamine, prostaglandin E2 and nitric oxide. This was all done at concentrations which could be delivered without toxicity in animal models. I think these are very early on in development and so far have only been tested in rats. The other was CMT-3 which inhibits the invasion of Candida albicans Quote Link to comment Share on other sites More sharing options...
Guest guest Posted June 4, 2002 Report Share Posted June 4, 2002 Marjorie, I have the reprint and could scan it in as a jpeg file and then post it. Would that work? I could also probably find the PDF file and upload it. I'll check tomorrow and do 1 of the 2. I'll let you know when it gets posted. > > > I looked into the IMPACs I mentioned in my last post a little bit > > > more. I found some info on two of them that seemed interesting. > > > > > > The first is called CMT-8. It has been shown to inhibit > > > TNF-(alpha). TNF-(alpha) makes the skin more receptive to VEGF, > > > and in the Fall of 2001, the NRS began a study to see if > > > inhibiting TNF-(alpha) might inhibit cea development. I'm > > > not sure if the study is finished yet. I guess I would assume > > > that if it is, and we haven't heard anything, that it was a > > > bust.. but.. this is their second year studying VEGF so obviously > > > they found something promising about it the first time... so.. > > > hopefully the study just isnt finished yet.. > > > > > > It also reduces blood levels of serum fructosamine, prostaglandin > > > E2 and nitric oxide. This was all done at concentrations which > > > could be delivered without toxicity in animal models. I think > > > these are very early on in development and so far have only been > > > tested in rats. > > > > > > The other was CMT-3 which inhibits the invasion of Candida > > > albicans > > > > > > > > > Quote Link to comment Share on other sites More sharing options...
Guest guest Posted June 4, 2002 Report Share Posted June 4, 2002 Marjorie, I have the reprint and could scan it in as a jpeg file and then post it. Would that work? I could also probably find the PDF file and upload it. I'll check tomorrow and do 1 of the 2. I'll let you know when it gets posted. > > > I looked into the IMPACs I mentioned in my last post a little bit > > > more. I found some info on two of them that seemed interesting. > > > > > > The first is called CMT-8. It has been shown to inhibit > > > TNF-(alpha). TNF-(alpha) makes the skin more receptive to VEGF, > > > and in the Fall of 2001, the NRS began a study to see if > > > inhibiting TNF-(alpha) might inhibit cea development. I'm > > > not sure if the study is finished yet. I guess I would assume > > > that if it is, and we haven't heard anything, that it was a > > > bust.. but.. this is their second year studying VEGF so obviously > > > they found something promising about it the first time... so.. > > > hopefully the study just isnt finished yet.. > > > > > > It also reduces blood levels of serum fructosamine, prostaglandin > > > E2 and nitric oxide. This was all done at concentrations which > > > could be delivered without toxicity in animal models. I think > > > these are very early on in development and so far have only been > > > tested in rats. > > > > > > The other was CMT-3 which inhibits the invasion of Candida > > > albicans > > > > > > > > > Quote Link to comment Share on other sites More sharing options...
Guest guest Posted June 4, 2002 Report Share Posted June 4, 2002 Marjorie, I have the reprint and could scan it in as a jpeg file and then post it. Would that work? I could also probably find the PDF file and upload it. I'll check tomorrow and do 1 of the 2. I'll let you know when it gets posted. > > > I looked into the IMPACs I mentioned in my last post a little bit > > > more. I found some info on two of them that seemed interesting. > > > > > > The first is called CMT-8. It has been shown to inhibit > > > TNF-(alpha). TNF-(alpha) makes the skin more receptive to VEGF, > > > and in the Fall of 2001, the NRS began a study to see if > > > inhibiting TNF-(alpha) might inhibit cea development. I'm > > > not sure if the study is finished yet. I guess I would assume > > > that if it is, and we haven't heard anything, that it was a > > > bust.. but.. this is their second year studying VEGF so obviously > > > they found something promising about it the first time... so.. > > > hopefully the study just isnt finished yet.. > > > > > > It also reduces blood levels of serum fructosamine, prostaglandin > > > E2 and nitric oxide. This was all done at concentrations which > > > could be delivered without toxicity in animal models. I think > > > these are very early on in development and so far have only been > > > tested in rats. > > > > > > The other was CMT-3 which inhibits the invasion of Candida > > > albicans > > > > > > > > > Quote Link to comment Share on other sites More sharing options...
Guest guest Posted June 5, 2002 Report Share Posted June 5, 2002 Marjorie, I got to thinking about that after I posted last night. I couldn't find a direct link through the net- even through the Univ. of Oklahoma Medical School Library. I did go to Dr. Sy's site and looked at the overview of the paper and it does give the basics, but not all of the details. Sorry for the confusion. > > > > > I looked into the IMPACs I mentioned in my last post a little > > bit > > > > > more. I found some info on two of them that seemed > interesting. > > > > > > > > > > The first is called CMT-8. It has been shown to inhibit > > > > > TNF-(alpha). TNF-(alpha) makes the skin more receptive to > VEGF, > > > > > and in the Fall of 2001, the NRS began a study to see if > > > > > inhibiting TNF-(alpha) might inhibit cea development. I'm > > > > > not sure if the study is finished yet. I guess I would assume > > > > > that if it is, and we haven't heard anything, that it was a > > > > > bust.. but.. this is their second year studying VEGF so > > obviously > > > > > they found something promising about it the first time... so.. > > > > > hopefully the study just isnt finished yet.. > > > > > > > > > > It also reduces blood levels of serum fructosamine, > > prostaglandin > > > > > E2 and nitric oxide. This was all done at concentrations > which > > > > > could be delivered without toxicity in animal models. I think > > > > > these are very early on in development and so far have only > been > > > > > tested in rats. > > > > > > > > > > The other was CMT-3 which inhibits the invasion of Candida > > > > > albicans > > > > > > > > > > > > > > > Quote Link to comment Share on other sites More sharing options...
Guest guest Posted June 5, 2002 Report Share Posted June 5, 2002 Marjorie, I got to thinking about that after I posted last night. I couldn't find a direct link through the net- even through the Univ. of Oklahoma Medical School Library. I did go to Dr. Sy's site and looked at the overview of the paper and it does give the basics, but not all of the details. Sorry for the confusion. > > > > > I looked into the IMPACs I mentioned in my last post a little > > bit > > > > > more. I found some info on two of them that seemed > interesting. > > > > > > > > > > The first is called CMT-8. It has been shown to inhibit > > > > > TNF-(alpha). TNF-(alpha) makes the skin more receptive to > VEGF, > > > > > and in the Fall of 2001, the NRS began a study to see if > > > > > inhibiting TNF-(alpha) might inhibit cea development. I'm > > > > > not sure if the study is finished yet. I guess I would assume > > > > > that if it is, and we haven't heard anything, that it was a > > > > > bust.. but.. this is their second year studying VEGF so > > obviously > > > > > they found something promising about it the first time... so.. > > > > > hopefully the study just isnt finished yet.. > > > > > > > > > > It also reduces blood levels of serum fructosamine, > > prostaglandin > > > > > E2 and nitric oxide. This was all done at concentrations > which > > > > > could be delivered without toxicity in animal models. I think > > > > > these are very early on in development and so far have only > been > > > > > tested in rats. > > > > > > > > > > The other was CMT-3 which inhibits the invasion of Candida > > > > > albicans > > > > > > > > > > > > > > > Quote Link to comment Share on other sites More sharing options...
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