Guest guest Posted June 4, 2002 Report Share Posted June 4, 2002 Um, I was doing a little research, and I'm not really sure if this is worth mentioning, as it basically confused me more than anything.. but I figured in case there was anyone who might be interested.. The company who makes the drug Periostat, which is currently indicated for periodontal disease, is going to begin clinical trials some time this year or early next year to try to show its effectiveness at treating acne and rosacea. I guess they already did a trial on acne and showed an average reduction of over 50%. It works by inhibiting enzymes that produce inflammation or something.. The company president seemed pretty excited about using this drug for acne/rosacea. At first I was sort of excited that there was a new product on the horizon, but then I looked into it a little more, and I think Periostat is actually just Doxycycline? I'm not quite sure why it has a different name.. and why it has to be tested for effeciacy for acne and rosacea since Doxycycline has already been approved for those two things by the FDA..probably something to do with the size of the dose I think. I guess the advantage to taking Periostat over Doxycycline will be that Periostat ISNT an antibiotic..this is supposeldy because Periostat is a much lower dose than Doxycycline.. (I inserted a paragraph I found about this at the bottom) So I guess the advantage to Periostat would be that it will hopefully be an effective treatment without all the antibiotic-related side effects.. (although it will still probably cause photosensitivity just like doxycycline) I added three links to websites that talk about it a little.. but I'm sure there are better ones out there. Incidentally, this same company recently invented a new dermal/transdermal drug delivery system or something.. called Restoraderm: " The technology is based on the ability of certain lipid compositions to enhance the natural skin barrier and facilitate the dermal and transdermal delivery of known active ingredients. " They are also in the process of developing compounds called IMPACs which they hope to use to treat various Inflammatory disorders, (including cea I think?) " Research has shown that the enzyme suppression technology underlying Periostat may also be applicable to other diseases involving destruction of the body's connective tissues, including cancer metastases (Metastat) and a broad range of inflammatory diseases. CollaGenex is developing a series of novel, proprietary compounds known as IMPACS (Inhibitors of Multiple Proteases and CytokineS) to address these applications. The Company intends to pursue further research and development of these technologies primarily through partnerships with third parties. " Anyway.. sorry to whomever this just bored the hell out of, but I have a feeling most people stopped reading all the way to the end of my posts a long time ago http://www.findarticles.com/cf_1/m4PRN/2002_Jan_7/81412725/p2/art icle.jhtml?term=collagenex http://biz.yahoo.com/bw/020212/122089_1.html http://www.periostat.com/ Is Periostat® an antibiotic? back to top Periostat® (doxycycline hyclate) 20 mg tablets are not an antibiotic. Periostat® has no detectable effect on bacteria. Although much higher dosages of doxycycline hyclate (for example, 100 mg and 200 mg per day) are used to treat (eliminate) bacterial infections, the dosage of doxycycline in Periostat® is much too low to kill bacteria. In early research, it was discovered that Periostat® (20 mg taken twice daily) reduced the activity of the tissue-destroying enzymes released in the gum tissue without affecting bacteria. Antibiotic dosages of doxycycline hyclate (100 mg and 200 mg per day) are only used for short periods of time, usually 10 to 14 days; long-term use of antibiotics may cause them to become less effective against bacteria. Quote Link to comment Share on other sites More sharing options...
Guest guest Posted June 4, 2002 Report Share Posted June 4, 2002 Adam, Thank you for sharing the results of your research with us. I know that I appreciate your efforts to keep abreast of possible new treatments for rosacea. Maybe one of them will provide a better treatment than is available now or even a cure -- that is a possibility. I believe that as the baby boomers age and more get rosacea, more serious research will be conducted. Hopefully, that has already begun. a Periostat Um, I was doing a little research, and I'm not really sure if this is worth mentioning, as it basically confused me more than anything.. but I figured in case there was anyone who might be interested.. The company who makes the drug Periostat, which is currently indicated for periodontal disease, is going to begin clinical trials some time this year or early next year to try to show its effectiveness at treating acne and rosacea. I guess they already did a trial on acne and showed an average reduction of over 50%. It works by inhibiting enzymes that produce inflammation or something.. The company president seemed pretty excited about using this drug for acne/rosacea. At first I was sort of excited that there was a new product on the horizon, but then I looked into it a little more, and I think Periostat is actually just Doxycycline? I'm not quite sure why it has a different name.. and why it has to be tested for effeciacy for acne and rosacea since Doxycycline has already been approved for those two things by the FDA..probably something to do with the size of the dose I think. I guess the advantage to taking Periostat over Doxycycline will be that Periostat ISNT an antibiotic..this is supposeldy because Periostat is a much lower dose than Doxycycline.. (I inserted a paragraph I found about this at the bottom) So I guess the advantage to Periostat would be that it will hopefully be an effective treatment without all the antibiotic-related side effects.. (although it will still probably cause photosensitivity just like doxycycline) I added three links to websites that talk about it a little.. but I'm sure there are better ones out there. Incidentally, this same company recently invented a new dermal/transdermal drug delivery system or something.. called Restoraderm: " The technology is based on the ability of certain lipid compositions to enhance the natural skin barrier and facilitate the dermal and transdermal delivery of known active ingredients. " They are also in the process of developing compounds called IMPACs which they hope to use to treat various Inflammatory disorders, (including cea I think?) " Research has shown that the enzyme suppression technology underlying Periostat may also be applicable to other diseases involving destruction of the body's connective tissues, including cancer metastases (Metastat) and a broad range of inflammatory diseases. CollaGenex is developing a series of novel, proprietary compounds known as IMPACS (Inhibitors of Multiple Proteases and CytokineS) to address these applications. The Company intends to pursue further research and development of these technologies primarily through partnerships with third parties. " Anyway.. sorry to whomever this just bored the hell out of, but I have a feeling most people stopped reading all the way to the end of my posts a long time ago http://www.findarticles.com/cf_1/m4PRN/2002_Jan_7/81412725/p2/art icle.jhtml?term=collagenex http://biz.yahoo.com/bw/020212/122089_1.html http://www.periostat.com/ Is Periostat® an antibiotic? back to top Periostat® (doxycycline hyclate) 20 mg tablets are not an antibiotic. Periostat® has no detectable effect on bacteria. Although much higher dosages of doxycycline hyclate (for example, 100 mg and 200 mg per day) are used to treat (eliminate) bacterial infections, the dosage of doxycycline in Periostat® is much too low to kill bacteria. In early research, it was discovered that Periostat® (20 mg taken twice daily) reduced the activity of the tissue-destroying enzymes released in the gum tissue without affecting bacteria. Antibiotic dosages of doxycycline hyclate (100 mg and 200 mg per day) are only used for short periods of time, usually 10 to 14 days; long-term use of antibiotics may cause them to become less effective against bacteria. Quote Link to comment Share on other sites More sharing options...
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