Guest guest Posted November 13, 2002 Report Share Posted November 13, 2002 Sorry...must have missed someone asking about Advair. What was the question? I'm on this med currently, for my asthma. Shanna mom of Triana, age 2 wcf Article on Advair CHEST: Cost-Effectiveness Analysis Suggests Advair (Fluticasone/Salmeterol) Associated with Lower Costs than Budesonide Plus Formoterol " By Peggy Peck Special to DG News SAN DIEGO, CA -- November 5, 2002 -- A cost-effectiveness analysis found that the asthma management combination fluticasone Advair =AE (fluticasone/salmeterol) is more cost effective than budesonide plus formoterol. Laureen Rance, MD of GlaxoKline, Canada, and colleagues used data collected from a Norwegian prospective multi-center study comparing fluticasone/salmeterol (FS) and budesonide (BUD)plus formoterol (FORM) to model projected Canadian costs. The European multicenter, 12-week, randomised, controlled trial enrolled adult asthmatics who were symptomatic on 1000 to 1600 =B5g inhaled beclomethasone (or equivalent). The researchers randomised 212 patients to FS at doses of 250/50 =B5g bid and 216 patients to BUD 800 =B5g bid plus FORM 12 =B5g bid. The researchers also collected non-protocol mandated asthma-related healthcare utilisation data during the trial. Canadian costs were applied to the secondary effectiveness measures: symptom-free nights, symptom-free days, episode-free days, and weeks with greater than 5 percent improvement from baseline in morning PEF. The primary objective of showing non-inferiority was met as the primary outcome morning PEF, as F/S produced similar results to BUD+FORM (p=3D0.593). Patients in the F/S arm had significantly more symptom-free nights (p<0.05) and significantly fewer exacerbations than those in the BUD+FORM arm. The F/S group had lower total daily asthma management costs ($3.60 per patient) than the BUD+FORM group ($4.96 per patient). The BUD+FORM group had a higher number of asthma-related hospitalisations, which resulted in higher mean treatment costs in that arm, she said. The study was funded by GlaxoKline, Canada. PLEASE do not post religious emails to the list. ------------------------------------------- The opinions and information exchanged on this list should IN NO WAY be construed as medical advice. PLEASE CONSULT YOUR PHYSICIAN BEFORE CHANGING ANY MEDICATIONS OR TREATMENTS. -------------------------------------------------- Quote Link to comment Share on other sites More sharing options...
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